Zobrazeno 1 - 10
of 93
pro vyhledávání: '"J.C. Theiss"'
Publikováno v:
Toxicology and Applied Pharmacology. 156:222-230
Fluoroquinolone antiinfective drugs exhibit phototoxic, photogenotoxic, and photocarcinogenic activities in experimental systems which may be interrelated. Clinafloxacin (CLX), a new fluoroquinolone, is a potent antiinfective agent being developed fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc3188123093e2b1662666905bfa68c
https://doi.org/10.1006/taap.1999.8653
https://doi.org/10.1006/taap.1999.8653
Publikováno v:
Environmental and Molecular Mutagenesis. 32:115-120
In this article, an integrated in vivo genotoxicity testing philosophy and a practical approach, as applied to pharmaceuticals, are described. Recently, there has been an effort to integrate the rodent (primarily rat) micronucleus assay with routine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d84cf4bb6c3844700c7db8daf9824c7d
https://doi.org/10.1002/(sici)1098-2280(1998)32:2<115::aid-em6>3.0.co
https://doi.org/10.1002/(sici)1098-2280(1998)32:2<115::aid-em6>3.0.co
Autor:
James Herman, John A. Anderson, Felix A. de la Iglesia, Alexander W. Gough, David G. Pegg, E. J. Mcguire, J.C. Theiss
Publikováno v:
The Journal of Toxicological Sciences. 21:207-214
Acute, subacute, and chronic toxicity studies, carcinogenicity bioassays, and reproductive and genetic toxicology studies were performed with quinapril, an ACE inhibitor used in the treatment of hypertension. Acute toxicity is minimal in rodents, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a8c4a4ab04fbb49c7a8db01e436b39
https://doi.org/10.2131/jts.21.4_207
https://doi.org/10.2131/jts.21.4_207
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 332:1-8
Apoptosis or programmed cell death is a biological event that is biochemically and morphologically distinct from cellular necrosis. Nonetheless, its relationship has not been studied in terms of a cytogenetic endpoint such as micronucleus formation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626b852e6980aef7d744656fa13edbbc
https://doi.org/10.1016/0027-5107(95)00075-3
https://doi.org/10.1016/0027-5107(95)00075-3
Publikováno v:
Mutation Research/Genetic Toxicology. 343:95-107
While HMG-CoA reductase inhibitors such as fluvastatin, lovastatin, pravastatin and simvastatin demonstrate lack of in vitro and in vivo mutagenicity and clastogenicity in bacterial and mammalian cells, long term rodent carcinogenicity studies result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c44cfb6f7f7de7f07d068da951acccee
https://doi.org/10.1016/0165-1218(95)90076-4
https://doi.org/10.1016/0165-1218(95)90076-4
Publikováno v:
Mutation Research Letters. 323:11-20
Bone marrow and spleen toxicity, clastogenicity and aneugenicity were analyzed in the CD1 mouse using an antikinetochore antibody (AKA) procedure (Krishna et al., Mutation Res., 282, 159–169, 1992). Further, to verify the fluorescence micronucleus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81388f37e598ebd2a2b4f1d962d463e9
https://doi.org/10.1016/0165-7992(94)90039-6
https://doi.org/10.1016/0165-7992(94)90039-6
Publikováno v:
Mutation Research Letters. 302:119-127
In the present study, cellulose-column fractionation methodology which has been used to eliminate nucleated cells in bone marrow was verified for its usefulness in micronucleus analysis and compared to standard smear methodology using cyclophosphamid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d2c82301ee6de4825f0f3ff65f0f60
https://doi.org/10.1016/0165-7992(93)90013-l
https://doi.org/10.1016/0165-7992(93)90013-l
Publikováno v:
European Journal of Medicinal Chemistry. 28:547-553
The bacterial mutagenicity of a series of compounds related to the mutagen 2-amino-3-methylimidazo[4,5- f ]quinoline (IQ) was determined in the Ames test using Salmonella strain TA-1538. Thiazolo[4,5- f ]quinoline-2-amine 3 and its 4,5-dihydro deriva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::588fc98c67236ca90ac7281b6be8300c
https://doi.org/10.1016/0223-5234(93)90085-s
https://doi.org/10.1016/0223-5234(93)90085-s
Publikováno v:
Mutation Research/Genetic Toxicology. 280:205-214
The genotoxicity of pirmenol was tested in the E. coli and S. typhimurium mutagenesis assay, an in vitro mammalian cell chromosome-aberration assay and an in vivo mouse micronucleus assay. The E. coli tester strain WP2s was exposed to concentrations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bcb212e69fee5f0b2518dc46eaa33a3
https://doi.org/10.1016/0165-1218(92)90050-a
https://doi.org/10.1016/0165-1218(92)90050-a
Publikováno v:
Mutation Research Letters. 282:159-167
An improved antikinetochore antibody technique was established in the mouse micronucleus assay to simultaneously evaluate toxicity, clastogenicity and aneugenicity induced by various test agents. The procedure involved the use of cellulose column fra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb052835801b9d317fcf317ee62a70a
https://doi.org/10.1016/0165-7992(92)90090-5
https://doi.org/10.1016/0165-7992(92)90090-5