Výsledky vyhledávání - "J.C. Kwekkeboom"

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Complement component C1q is produced by isolated articular chondrocytes

Autor: J.C. Kwekkeboom, R.A. van Schaarenburg, R. Mahdad, Rik Lories, Andreea Ioan-Facsinay, A Bakker, Silvia Monteagudo, Chahrazad Cherifi, R. Lubbers, Rem Toes, E W N Levarht, Leendert A. Trouw

Publikováno v: Osteoarthritis and Cartilage
Osteoarthritis and Cartilage, 28(5), 675-684. ELSEVIER SCI LTD

OBJECTIVE: Inflammation and innate immune responses may contribute to development and progression of Osteoarthritis (OA). Chondrocytes are the sole cell type of the articular cartilage and produce extracellular-matrix molecules. How inflammatory medi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9efa5667e20d85e945cbf3ea0be20560
https://doi.org/10.1016/j.joca.2019.09.007

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Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications

Autor: M. Reth, E W N Levarht, Hans Scherer, J.C. Kwekkeboom, J. W. Drijfhout, Holger Bang, Sanne Reijm, Gerrie Stoeken-Rijsbergen, Arieke S. B. Kampstra, George M.C. Janssen, P.A. van Veelen, Marco Cavallari, Corrie M. Wortel, Rem Toes, Twj Huizinga, Theresa Kissel, Rochelle D Vergroesen, Kimberly M. Bonger, Linda M. Slot

Publikováno v: Annals of the rheumatic diseases, 79(4):216499, 472-480. BMJ Publishing Group
Annals of the Rheumatic Diseases, 79, 472-480
Annals of the Rheumatic Diseases, 79, 4, pp. 472-480
Annals of the Rheumatic Diseases, 79(4), 472-480. BMJ PUBLISHING GROUP
Annals of the rheumatic disease

ObjectiveAutoantibodies against antigens carrying distinct post-translational modifications (PTMs), such as citrulline, homocitrulline or acetyllysine, are hallmarks of rheumatoid arthritis (RA). The relation between these anti-modified protein antib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88893b425b91fa2311059af461e13bb1
https://doi.org/10.1136/annrheumdis-2019-216499

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Immunoprofiling of early, untreated rheumatoid arthritis using mass cytometry reveals an activated basophil subset inversely linked to ACPA status

Autor: Marjolijn Hameetman, J.C. Kwekkeboom, Vincent van Unen, A.H.M. van der Helm-van Mil, Guillaume Beyrend, F. A. van Gaalen, Rem Toes, Hester Koppejan

Publikováno v: Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-11 (2021)
Arthritis Research and Therapy, 23(1). BMC

Background Autoantibody production is a hallmark of rheumatoid arthritis (RA). Anti-citrullinated protein antibodies (ACPA) are highly disease-specific, and their presence is associated with more severe disease and poor prognosis compared to ACPA-neg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ea73d0021e2ca9456256af6ef985e0
http://europepmc.org/articles/PMC8555233

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Anti-inflammatory and proresolving effects of the omega-6 polyunsaturated fatty acid adrenic acid

Autor: Margreet Kloppenburg, Mauro Perretti, René E. M. Toes, Bryce A. Binstadt, Mayra Gonzalez-Torres, Tom W J Huizinga, Cristina López-Vicario, Hilde Brouwers, Jennifer L. Auger, Jose Garrido-Mesa, Joan Clària, M. Giera, Hulda S Jónasdóttir, J.C. Kwekkeboom, Jona Freysdottir, Ingibjorg Hardardottir, Andreea Ioan-Facsinay, Marije E. Kuipers, Lucy V. Norling

Publikováno v: Journal of Immunology, 205(10), 2840-2849. AMER ASSOC IMMUNOLOGISTS

Polyunsaturated fatty acids (PUFAs) and their metabolites are potent regulators of inflammation. Generally, omega (n)-3 PUFAs are considered proresolving whereas n-6 PUFAs are classified as proinflammatory. In this study, we characterized the inflamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965b1ca862943353cbc2c7e256bd6946
https://doi.org/10.4049/jimmunol.1801653

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Targeted lipidomics reveals activation of resolution pathways in knee osteoarthritis in humans

Autor: René E. M. Toes, Twj Huizinga, Hulda S. Jónasdóttir, Andreea Ioan-Facsinay, Margreet Kloppenburg, H. M. J. van der Linden, J.C. Kwekkeboom, Martin Giera, Hilde Brouwers

Publikováno v: Osteoarthritis and Cartilage, 25(7), 1150-1160

Summary Objective To investigate the presence of inflammation and resolution pathways in osteoarthritis (OA). Design Tissues were obtained from knee OA patients and control rheumatoid arthritis (RA) patients. Cells in synovial fluid (SF) were visuali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740dbde51d178189a539769392684b6d
https://doi.org/10.1016/j.joca.2017.01.018

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POS0384 A NOVEL MECHANISM LINKING MUCOSAL BACTERIA WITH AUTOANTIBODY RESPONSES IN RA: ACETYLATED BACTERIAL LYSATE AS A MODEL ANTIGEN

Autor: J.C. Kwekkeboom, Rem Toes, M. Volkov, Arieke S. B. Kampstra, Twj Huizinga, D. van der Woude, K. van Schie

Publikováno v: Annals of the Rheumatic Diseases. 80:422.1-422

Background:Rheumatoid arthritis (RA) is characterized by autoantibodies against post-translationally modified proteins (AMPA) such as citrullinated, carbamylated and acetylated proteins. Importantly, these antibodies are highly multireactive, as they

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9fe6c844ef2c0494c4e213db2b1d6c5
https://doi.org/10.1136/annrheumdis-2021-eular.1709

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