Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy

Autor: Céline Dinocourt, Angel Merchán-Pérez, J. De Felipe, J.C. Hirsch, Christophe Bernard, Rosa Cossart, Yehezkel Ben-Ari, Monique Esclapez

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Neuroscience
Nature Neuroscience, Nature Publishing Group, 2001, 4 (1), pp.52-62. ⟨10.1038/82900⟩
ResearcherID

Impaired inhibition is thought to be important in temporal lobe epilepsy (TLE), the most common form of epilepsy in adult patients. We report that, in experimental TLE, spontaneous GABAergic inhibition was increased in the soma but reduced in the den

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4353770e71f829534fd1083fc4975ce8
https://doi.org/10.1038/82900

Enhanced NMDAR-dependent epileptiform activity is controlled by oxidizing agents in a chronic model of temporal lobe epilepsy

Autor: O. Quesada, Henri Gozlan, J.C. Hirsch, Yehezkel Ben-Ari, Christophe Bernard, Monique Esclapez

Publikováno v: Europe PubMed Central
ResearcherID
Scopus-Elsevier

1. Graded N-methyl-D-aspartate receptor (NMDAR)-dependent epileptiform discharges were recorded from ex vivo hippocampal slices obtained from rats injected a week earlier with an intracerebroventricular dose of kainic acid. Intracellular recordings f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c04682cfd10abac9f9e51344772103a
https://doi.org/10.1152/jn.1996.76.6.4185

Dopamine-deprived striatal GABAergic interneurons burst and generate repetitive gigantic IPSCs in medium spiny neurons

Autor: C. Lopez, Nathalie Dehorter, Céline Guigoni, Yehezkel Ben-Ari, J.C. Hirsch, Alexandre Eusebio, Constance Hammond

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(24)

Striatal GABAergic microcircuits modulate cortical responses and movement execution in part by controlling the activity of medium spiny neurons (MSNs). How this is altered by chronic dopamine depletion, such as in Parkinson's disease, is not presentl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c0b1c527923891b7fb48c3a9dfbb991
https://pubmed.ncbi.nlm.nih.gov/19535589

Quantal release of glutamate generates pure kainate and mixed AMPA/kainate EPSCs in hippocampal neurons

Autor: Roman Tyzio, Hélène Becq, Yehezkel Ben-Ari, J.C. Hirsch, Valérie Crépel, Jérôme Epsztein, Rosa Cossart

Publikováno v: Neuron
Neuron, Elsevier, 2002, 35 (1), pp.147-59
HAL

International audience; The relative contribution of kainate receptors to ongoing glutamatergic activity is at present unknown. We report the presence of spontaneous, miniature, and minimal stimulation-evoked excitatory postsynaptic currents (EPSCs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8096c33a3aedc46c5bc4eb5ef3f0203
https://www.hal.inserm.fr/inserm-00484870/file/CossartAdvInBiochPsych2002.pdf

Presynaptic kainate receptors that enhance the release of GABA on CA1 hippocampal interneurons

Autor: Rosa Cossart, Yehezkel Ben-Ari, Roman Tyzio, Monique Esclapez, Céline Dinocourt, J.C. Hirsch, Christophe Bernard

Publikováno v: Neuron
Neuron, Elsevier, 2001, 29 (2), pp.497-508
HAL

International audience; We report that kainate receptors are present on presynaptic GABAergic terminals contacting interneurons and that their activation increases GABA release. Application of kainate increased the frequency of miniature inhibitory p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3edc99ec1710f7e2a32c0e68ec2cb607
https://www.hal.inserm.fr/inserm-00484921/file/CossartNeuron2001.pdf