ZnO-mesoporous glass scaffolds loaded with osteostatin and mesenchymal cells improve bone healing in a rabbit bone defect

Autor: A Gómez-Blasco, Sandra Sánchez-Salcedo, María Vallet-Regí, V E Gómez-Palacio, J.C. Doadrio, Jorge Gil-Albarova, Daniel Lozano, Antonio J. Salinas, C. Heras

Publikováno v: Journal of Materials Science-Materials in Medicine
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
E-Prints Complutense. Archivo Institucional de la UCM
instname
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
Zaguán. Repositorio Digital de la Universidad de Zaragoza

The use of 3D scaffolds based on mesoporous bioactive glasses (MBG) enhanced with therapeutic ions, biomolecules and cells is emerging as a strategy to improve bone healing. In this paper, the osteogenic capability of ZnO-enriched MBG scaffolds loade

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb30f06f1e841f27e6fd08674343590

Mesoporous silica nanoparticles as a new carrier methodology in the controlled release of the active components in a polypill

Autor: Antonio L. Doadrio, Antonio J. Salinas, José M. Sánchez-Montero, J.C. Doadrio, María Vallet-Regí

Publikováno v: E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
E-Prints Complutense. Archivo Institucional de la UCM
instname

Polypill is a medication designed for preventing heart attacks through a combination of drugs. Current formulations contain blood pressure-lowering drugs and others, such statins or acetylsalicylic acid. These drugs exhibit different physical chemica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60826c1e7653a5f110e3d2984ce69c6

Osteostatin-loaded onto mesoporous ceramics improves the early phase of bone regeneration in a rabbit osteopenia model

Autor: Antonio J. Salinas, María Vallet-Regí, Pedro Esbrit, Natalio García-Honduvilla, J.C. Doadrio, Cynthia Trejo, Julia Buján, Daniel Lozano, Enrique Gómez-Barrena, Miguel Manzano

Publikováno v: Acta Biomaterialia. 8:2317-2323

Parathyroid hormone-related protein (PTHrP) is an important modulator of bone formation. Recently, we reported that PTHrP (107–111) (osteostatin) coating onto mesoporous ceramics confers osteogenic activity to these materials. Bone repair is dramat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa1fb0331304865014a2a4f07365087
https://doi.org/10.1016/j.actbio.2012.03.014

A rational explanation of the vancomycin release from SBA-15 and its derivative by molecular modelling

Autor: Antonio L. Doadrio, José M. Sánchez-Montero, Antonio J. Salinas, María Vallet-Regí, J.C. Doadrio

Publikováno v: Microporous and Mesoporous Materials. 132:559-566

SBA-15 was investigated for the controlled release of vancomycin. The kinetic of release drastically changed after functionalizing the mesoporous material with octyltrimethoxysilane (C8) chains. That way, the kinetic constant of release decreased fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56608480bc9751c5ce0b60507b16897f
https://doi.org/10.1016/j.micromeso.2010.04.010

Osteostatin-loaded bioceramics stimulate osteoblastic growth and differentiation

Autor: Pedro Esbrit, María Vallet-Regí, Daniel Lozano, Antonio J. Salinas, J.C. Doadrio, Miguel Manzano, Enrique Gómez-Barrena

Publikováno v: Acta Biomaterialia. 6:797-803

Parathyroid hormone-related protein (PTHrP) is an important regulator of bone remodeling. Recent studies show that this protein can induce osteogenic features through its N- and C-terminal domains. Silica-based ordered mesoporous bioceramics with an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3429e614c1c52cefadb183211432d00
https://doi.org/10.1016/j.actbio.2009.08.033