Zobrazeno 1 - 10
of 50
pro vyhledávání: '"J.C. Brelière"'
Autor:
G. Le Fur, S Daoul, J.C. Brelière, D. Van Broeck, M. Poncelet, Charles Advenier, Jean-Philippe Ducoux, Marco Landi, Emmanuel Naline, C Cognon, Philippe Soubrie, Vincenzo Proietto, X. Emonds-Alt, P. Vilain, Gervais Neliat, J P Maffrand, T. Croci
Publikováno v:
Neuropeptides. 31:449-458
(R)-3-(1-[2-(4-benzoyl-2-(3,4-difluorophenyl)-morpholin-2-yl)- ethyl]-4-phenylpiperidin-4-yl)-1-dimethylurea (SR 144190) is a new non-peptide antagonist of tachykinin NK2 receptors. SR 144190 potently and selectively inhibited neurokinin A binding to
Autor:
J. Souilhac, J.C. Brelière, R. Calassi, X. Emonds-Alt, Philippe Soubrie, G. Le Fur, Jeanne Maruani, Christiane Gueudet, M. Jung, M. Poncelet, M.C. Barnouin
Publikováno v:
Neuropharmacology. 33:167-179
SR 140333 (1-2-[3-(3,4-dichlorophenyl)-1-(3-isopropoxyphenylacetyl)piperidin-3-yl]ethyl-4-phenyl -1-azonia-bicyclo[2.2.2]octane, chloride), a potent non peptide ligand of the substance P (SP) NK1 receptor subtype with high affinity for NK1 receptors
Autor:
J.C. Brelière, C. Bernhart, Colette Lacour, A. Roccon, D. Nisato, Jean Gougat, Catherine Cazaubon, G. Le Fur, J.‐L. A. Assens, F.B. Hundricourt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:157-162
A novel series of substituted 3H-dihydro-pyrimidinones, homologues of SR 47436, was identified as AT 1 receptor antagonists. The best compounds showed high affinity for the AT 1 receptor (rate liver membrane prepration) with IC 50 's in the nanomolar
Autor:
Bernard Ferrari, Jacques Clement, A. Roccon, Yvette Muneaux, Claude Bernhart, Claude Muneaux, J.C. Brelière, J. Taillades, D. Nisato, P. Perreaut, G. Le Fur, Jean Gougat, F. Haudricourt, Colette Lacour, Catherine Cazaubon, J.‐L. A. Assens, P. Guiraudou, M.‐A. Vignal
Publikováno v:
ChemInform. 25
Autor:
Nguyen Qt, Regoli D, Emmanuel Naline, J.C. Brelière, X. Emonds-Alt, Charles Advenier, Rouissi N, Neliat G
Publikováno v:
Biochemical and Biophysical Research Communications. 184:1418-1424
SR 48968, a new non-peptide antagonist of NK 2 receptors, has been tested in a variety of isolated smooth muscle preparations from rats, guinea pigs, rabbits, hamsters and men, in order to assess its selectivity for NK 2 receptors as well as its comp
Autor:
M. Fournier, Philippe Soubrie, J.C. Brelière, J.-C Michaud, R. Calassi, R. Alonso, G. Le Fur, Christiane Gueudet
Publikováno v:
Fundamentalclinical pharmacology. 12(1)
Trigeminal stimulation of C-fibers increased c-fos expression within the trigeminal nucleus caudalis (NtV) and thalamic neuronal activity which both reflect the transmission of a nociceptive message. We examined the effects on both these phenomena of
Publikováno v:
FEBS letters. 399(3)
Substance P (SP) has been reported to induce inflammatory cytokine production in human neuroglial cells and peripheral lymphoid cells as well. In order to evaluate the potency of novel non-peptide antagonists of the tachykinin receptors as inhibitors
Autor:
X K Nguyen-Le, J.C. Brelière, Fernand Gobeil, L H Pheng, Domenico Regoli, X. Emonds-Alt, Q.T. Nguyen
Publikováno v:
Pharmacology. 52(5)
Pharmacological and biochemical assays were performed to characterize SR 142801, a new NK-3 receptor antagonist, and its [R]-enantiomer, SR 142806. The compounds were tested (1) in the guinea pig isolated ileum stimulated with [MePhe7]NKB (NK-3 syste
Autor:
P. Vilain, J.C. Brelière, Emmanuel Naline, Le Fur G, Charles Advenier, X. Emonds-Alt, H. Bakdach, L. Toty
Publikováno v:
The American review of respiratory disease. 146(5 Pt 1)
Tachykinins produce concentration-dependent contraction of the human isolated bronchus by stimulation of receptors that belong to the NK2 type. The aim of this study was to investigate the inhibitory effects of a new, potent, and selective nonpeptide
Autor:
Emmanuel Naline, Pierre Yves Andre Goulaouic, J.C. Brelière, G. Le Fur, D. Van Broeck, Gervais Neliat, Vincenzo Proietto, P. Vilain, Charles Advenier, X. Emonds-Alt
Publikováno v:
Life sciences. 50(15)
SR 48968 is a potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor. SR 48968 selectively inhibited neurokinin A binding to its receptor and was a competitive antagonist of neurokinin A-mediated contraction of different isola