Zobrazeno 1 - 10
of 156
pro vyhledávání: '"J.A. Raleigh"'
Publikováno v:
International Journal of Radiation Biology. 58:1025-1034
SummarySelective retention of hexafluoromisonidazole, CCI-103F, in RIF-1 and SCCVII tumours of C3H/Km mice has been measured by 1H/19F magnetic resonance spectroscopy (MRS) on a Bruker AM-400 multinuclear spectrometer. CCI-103F concentrations in tumo
Autor:
S.F. Liu, J.A. Raleigh
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 10:1337-1340
Glyoxal has been identified as a product in the fragmentation of reduced 2-nitroimidazole radiosensitizers. Quantitative analysis of glyoxal as its his (2,4-dinitrophenylhydrazone) derivative shows that it is formed in good yield (9–23%) in a varie
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 12:1263-1267
Treatment-resistant, chronically hypoxic tumor cells have been assumed to exist in some solid human tumors, limiting their curability. To date, six patients with different types of tumors have been studied using radioactive labelled electron affinic
Autor:
J.A. Raleigh, W. Kremers
Publikováno v:
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine. 39:441-444
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 8:701-704
Reductive activation of misonidazole and misondiazole acetate, a simple derivative, in the presence of xanthine oxidase causes inactivation of the enzyme. The inactivation is not accompanied by binding of the misonidazole to the enzyme. The nitroredu
Publikováno v:
Biochemical Pharmacology. 38:665-670
The 2-nitroimidazole, misonidazole, is of current interest as an imaging agent for hypoxic regions in tumors and in vascular disease such as stroke. The basis of this technique is the reductive activation and binding of nitroheterocycles which is muc
Publikováno v:
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine. 31:203-213
Cellular membranes have been suggested as possible loci for the development of the oxygen effect in radiobiology. Unsaturated lipids from membranes are subject to very efficient radiation-induced peroxidation, and the deleterious effects generally as
Autor:
B.J. Blackburn, J.A. Raleigh
Publikováno v:
Biochemical and Biophysical Research Communications. 83:1061-1066
One of the two possible C 5 ′ epimers of 8,5′-cycloadenosine 5′-monophosphate is a substrate for snake venom 5′-nucleotidase. A stereospecific, radiation chemical synthesis has produced one of the epimers in pure form whose configuration at C