Výsledky vyhledávání - "J.A. Hellings"

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An Amino-terminal Amphipathic α-Helix Mediates Membrane Association of the Hepatitis C Virus Nonstructural Protein 5A

Autor: Volker Brass, François Penin, Darius Moradpour, Elke Bieck, Benno Wölk, Hubert E. Blum, Roland Montserret, J.A. Hellings

Publikováno v: Journal of Biological Chemistry. 277:8130-8139

Hepatitis C virus (HCV) nonstructural protein 5A (NS5A), a phosphoprotein of unknown function, is believed to be a component of a membrane-associated viral replication complex. The determinants for membrane association of NS5A, however, have not been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb768a99f925b9775230aa4452a0f42
https://doi.org/10.1074/jbc.m111289200

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Characteristics of the early phase of chronicity in acute hepatitis B infection

Autor: M. H. van Roosmalen, R. A. Heijtink, Solko W. Schalm, J.A. Hellings, Hubert G. M. Niesters, A. D. M. E. Osterhaus, W. P. Paulij

Publikováno v: Journal of Medical Virology, 57, 331-336. Wiley-Liss Inc.

The mechanism of development of chronicity after acute hepatitis B infection has not been elucidated fully. Following a single source outbreak of hepatitis B among 79 adult women, three patients (4%) became chronic carriers of hepatitis B virus (HBV)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93d1ad32def9304fdc1bac2d10df1cc
https://doi.org/10.1002/(sici)1096-9071(199904)57:4<331::aid-jmv1>3.0.co

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A microELISA system for the detection of both anti-HIV-1 and anti-HIV-2 antibodies

Autor: J.A. Hellings, H.J. Theunissen, E.D. Sprengers, P. B. W. Ten Kortenaar

Publikováno v: Journal of Immunological Methods. 139:77-82

Current anti-HIV-1 screening tests combine an excellent anti-HIV-1 sensitivity with a sensitivity of only 28–93% for anti-HIV-2 positive plasma or serum samples. The reactivity of anti-HIV-2 sera in anti-HIV-1 screening tests is based mainly on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f9228295684550ff53f621fc230b06
https://doi.org/10.1016/0022-1759(91)90353-h

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A new HBsAg screening assay designed for sensitive detection of HBsAg subtypes and variants

Autor: T. Jacobs, G.J.C.M. Ahlers-de Boer, J.J. de Jong, F. Couwenberg, W. Haenen, J.A. Hellings, M.H. van Roosmalen

Publikováno v: Intervirology. 49(3)

The design of a new HBsAg screening assay, the Hepanostika HBsAg Ultra is based on the use of monoclonal antibodies raised against native wild-type HBsAg and reactive with HBsAg in which the common ‘a’-determinant is modified by site-directed mut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeb1d02b7f76b84aba3be3652a44dd54
https://pubmed.ncbi.nlm.nih.gov/16428888

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Characterization of DS-antigen, an antigen related to non-A, non-B hepatitis. I. Physico-chemical properties

Autor: J.A. Hellings, W. Duermeyer, R. Stute

Publikováno v: Journal of Virological Methods. 6:225-232

An enzyme-linked immunosorbent assay for an antigen (termed DS-Ag) related to non-A, non-B hepatitis has recently been developed in our laboratory. The DS-Ag was derived from a proven infectious serum obtained from a patient with haemophilia and it w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843d435a29c1386b228725812f23755b
https://doi.org/10.1016/0166-0934(83)90049-6

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Non-A, Non-B Hepatitis in Hemophilic Patients with Inhibitor Treated with Activated Prothrombin Complex Concentrates: Lack of Correlation with an Antigen Possibly Related to Non-A, Non-B Hepatitis

Autor: J.A. Hellings, W. Duermeijer, C. Gazengel, F. Verroust, Y. Laurian, Jean-Pierre Allain

Publikováno v: Vox Sanguinis. 47:47-53

A population of 30 severe hemophilia-A patients with antibodies to factor VIII, treated with Autoplex® since 1980, experienced a 30% incidence of non-A, non-B (NANB) hepatitis. 8 of the 9 patients affected had clinical signs of hepatitis and 7 had A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7213d38fa58a20be95fec85038149a69
https://doi.org/10.1111/j.1423-0410.1984.tb01560.x

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An enzyme-linked immunosorbent assay for an antigen related to non-a, non-b hepatitis and its antibody: Partial characterization of the antigen and chimpanzee transmission

Autor: R. Stute, W. Duermeyer, J.A. Hellings

Publikováno v: Journal of Medical Virology. 11:11-21

An enzyme-linked immunosorbent assay (ELISA) was developed based on sera from patients convalescent from non-A, non-B hepatitis and haemophilia A patients who had been frequently treated with commercial blood products. Using this ELISA, an antigen wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4a74fb7853eacd5aaef87802d86be8
https://doi.org/10.1002/jmv.1890110103

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