Zobrazeno 1 - 10
of 109
pro vyhledávání: '"J.A. Court"'
Publikováno v:
Neurobiology of Disease, Vol 19, Iss 3, Pp 366-377 (2005)
The cholinergic system has been implicated in the development of autism on the basis of neuronal nicotinic acetylcholine receptor (nAChR) losses in cerebral and cerebellar cortex. In the present study, the first to explore nAChRs in the thalamus in a
Externí odkaz:
https://doaj.org/article/594eeb2c583d4a569e41cd7e24e451be
Autor:
Melissa Ray, Robert H. Perry, Ian G. McKeith, Iwo Bohr, J.A. Court, Clive Ballard, Sylvie Chalon, Elaine K. Perry, Margaret A. Piggott, Denis Guilloteau, J. Michael McIntosh
Publikováno v:
Neuroscience Letters. 372:220-225
Dementia with Lewy bodies (DLB) is a neurodegenerative disease associated with a range of neuropsychiatric symptoms and reduced expression of neuronal nicotinic acetylcholine receptors (nAChRs) in neocortex, hippocampus, thalamus and basal ganglia. T
Publikováno v:
Neuropathology and Applied Neurobiology. 30:243-254
Increases in neuronal nicotinic receptors (nAChRs) in response to nicotine exposure have been reported in cell cultures, rodent brains, and in the brains of human smokers. The present study examines alterations in alpha4 and alpha7 nAChR subunit cell
Autor:
Elaine K. Perry, J.A. Court
Publikováno v:
International Psychogeriatrics. 15:81-87
A number of neurotransmitters, including acetylcholine, serotonin, noradrenaline, and dopamine, modulate cerebral perfusion. In vascular dementia, reductions in markers of cholinergic innervation are consistently reported, and there are some indicati
Autor:
Carmen Martin-Ruiz, Robert H. Perry, A Kuryatov, Evelyn Jaros, J.A. Court, Mark R. Cookson, Jon Lindstrom, S Lawrence, Elaine K. Perry, Margaret A. Piggott, Cecilia Gotti
Publikováno v:
Neuroscience Letters. 335:134-138
A reduction in nicotinic receptor (nAChR) binding has previously been observed in putamen in Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The present study demonstrates no concommitant reduction in the expression of alpha2-alpha7, be
Autor:
Carmen Martin-Ruiz, Socrates J. Tzartos, T. Tsouloufis, J.A. Court, Elaine K. Perry, Robert H. Perry, M. Lee, Avgi Mamalaki, Cecilia Gotti, Clive Ballard, E. Molnar
Publikováno v:
Journal of Neurochemistry. 73:1635-1640
Neuronal nicotinic acetylcholine receptors labelled with tritiated agonists are reduced in the cerebral cortex in Alzheimer's disease (AD), but to date it has not been demonstrated which nicotinic receptor subunits contribute to this deficit. In the
Autor:
Carmen Martin-Ruiz, M.S Siddique, A.D Mendelow, J.A. Court, Jon Lindstrom, Elaine K. Perry, Cecilia Gotti, Margaret A. Piggott, Robert H. Perry
Publikováno v:
Neuropharmacology. 39:2830-2839
It is well established that nicotinic receptors in the mammalian striatum are involved in modulation of the release of several neurotransmitters, including dopamine. In addition, nicotinic receptors with high affinity for agonists have generally been
Publikováno v:
Journal of Chemical Neuroanatomy. 20:281-298
Brain nicotinic acetylcholine receptors (nAChR) are a class of ligand-gated channels composed of alpha and beta subunits with specific structural, functional and pharmacological properties. They participate in the physiological and behavioural effect
Autor:
Raj N. Kalaria, Robert H. Perry, Carmen Martin-Ruiz, Mark I. Johnson, J.A. Court, Elaine K. Perry, M. Lee, Margaret A. Piggott, Clive Ballard
Publikováno v:
Acta Neurologica Scandinavica. 102:34-41
Objectives - Comparisons were made of nicotinic receptors in 3 major forms of dementia in old age. Although it is well established the involvement of nicotinic receptors in Alzheimer's disease (AD), their status in the other two main causes of dement
Autor:
J.A. Court, E. Hellström-Lindahl
Publikováno v:
Behavioural Brain Research. 113:159-168
Nicotinic acetylcholine receptor (nAChRs) proteins and gene transcripts are already present in human prenatal brain and spinal cord at 4-6 weeks gestation, and a clear age-related increase in number of nAChRs was apparent during first trimester. In p