Zobrazeno 1 - 10
of 22
pro vyhledávání: '"J.A. Cadée"'
Autor:
Wim E. Hennink, J.A. Cadée, Caspaar Bijleveld, J. W. Koten, Linda A. Brouwer, M.J.A. van Luyn, W. Den Otter
Publikováno v:
Cytokine, 24(3), 57-66
Biodegradable dextran microspheres (MS) were developed as a slow-release system for interleukin-2 (IL-2) to apply them for local IL-2 therapy of cancer. We describe the tissue reactions induced by these MS without or with IL-2 in rats. Dextran MS sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e66e20801cb56cc4ce4842635c0c005
https://research.rug.nl/en/publications/0aa3069b-c9e2-4bf3-80fc-88aad3c8600b
https://research.rug.nl/en/publications/0aa3069b-c9e2-4bf3-80fc-88aad3c8600b
Publikováno v:
International Journal of Cancer. 98:134-140
Interleukin-2 (IL-2) is a highly effective anticancer drug if it is applied locally for 5 consecutive days. In most cases this requires 5 invasive treatments, which is not usually acceptable for either the patient or the clinician. For this reason we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c477c30e143401e9dc376343ab06f61
https://doi.org/10.1002/ijc.10167
https://doi.org/10.1002/ijc.10167
Autor:
Willy J. M. Underberg, Mies J. van Steenbergen, Wim Jiskoot, Willem Den Otter, Cees Versluis, Wim E. Hennink, J.A. Cadée, Albert J. R. Heck
Publikováno v:
Pharmaceutical Research. 18:1461-1467
Purpose. The oxidation of recombinant human interleukin-2 (rhIL-2) by potassium peroxodisulfate (KPS) with or without N,N,N′,N′-tetramethylethylenediamine (TEMED), which are used for the preparation of dextran-based hydrogels, was investigated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72e9e23cfc5de6a6efd57b0435d5c800
https://doi.org/10.1023/a:1012213108319
https://doi.org/10.1023/a:1012213108319
Autor:
Cristiano Iurisci, Gerry T. Snoek, J.A. Cadée, Karel W. A. Wirtz, Daniela Corda, Christopher P. Berrie, Hester A. van der Helm, Teunis Bernard Herman Geijtenbeek
Publikováno v:
Journal of biological chemistry, 274(50), 35393-35399. American Society for Biochemistry and Molecular Biology Inc.
In order to investigate the cellular function of the mammalian phosphatidylinositol transfer protein alpha (PI-TPalpha), NIH3T3 fibroblast cells were transfected with the cDNA encoding mouse PI-TPalpha. Two stable cell lines, i.e. SPI6 and SPI8, were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233e56988e36b9afccda9e85e02db97b
https://doi.org/10.1074/jbc.274.50.35393
https://doi.org/10.1074/jbc.274.50.35393
Publikováno v:
Polymer. 40:6877-6881
This paper describes the synthesis and characterization of 2-(methacryloyloxy) ethyl-l-lactate and 2-(methacryloyloxy)ethyl-di-l-lactate. These compounds were obtained by reaction of l-lactide and 2-hydroxyethyl methacrylate (HEMA) at a molar ratio o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::393838e0125ef9c40e34f75aab70235d
https://doi.org/10.1016/s0032-3861(99)00354-7
https://doi.org/10.1016/s0032-3861(99)00354-7
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 78(1-3)
In this study, the release of recombinant human interleukin-2 (rhIL-2) from methacrylated dextran (dex-MA) and (lactate-)hydroxyethyl methacrylated dextran (dex-(lactate-)HEMA) hydrogels with varying crosslink density was investigated. Hydrogels deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993fc7845910c0e12dbcc4e61b09535c
https://pubmed.ncbi.nlm.nih.gov/11772444
https://pubmed.ncbi.nlm.nih.gov/11772444
Autor:
J.A. Cadée, S. J. de Jong, R.J.H. Stenekes, Herre Talsma, Wilhelmus Everhardus Hennink, O. Franssen, W. N. E. Van Dijk-Wolthuis
Publikováno v:
Biomedical Polymers and Polymer Therapeutics ISBN: 9780306464720
A biodegradable and biocompatible dextran hydrogel system has been developed of which the degradation time can be tailored between 2 days and 3 months. This chapter shows that hydrogels based on crosslinked dextrans have unique properties as protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c72c29c90180a291acf30ba874d7d66
https://doi.org/10.1007/0-306-46842-5_1
https://doi.org/10.1007/0-306-46842-5_1
Publikováno v:
Journal of Biomedical Materials Research, 56(4), 600-609. Wiley
Microspheres based on methacrylated dextran (dex-MA), dextran derivatized with lactate-hydroxyethyl methacrylate (dex-lactate-HEMA) or derivatized with HEMA (dex-HEMA) were prepared. The microspheres were injected subcutaneously in rats and the effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1bfe1b28bddf00af7ec232a2c43e20f
https://research.rug.nl/en/publications/5311555f-4012-4ec4-8779-d7bc88071a59
https://research.rug.nl/en/publications/5311555f-4012-4ec4-8779-d7bc88071a59
Autor:
C.J. De Groot, Wim E. Hennink, Josee A. Plantinga, P.B. van Wachem, J.A. Cadée, Mja van Luyn, Linda A. Brouwer, W. Den Otter
Publikováno v:
Journal of Biomedical Materials Research, 50(3), 397-404. Wiley
Dextran-based hydrogels were obtained by polymerization of aqueous solutions of methacrylated dextran (dex-MA) or lactate-hydroxyethyl methacrylate-derivatized dextran (dex-lactate-HEMA). Both nondegradable dex-MA and degradable dex-lactate-HEMA disk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fbb9e37bf75f515f87e4d892b09a2c
https://research.rug.nl/en/publications/6095f442-6a44-4077-84c0-276c2a2ed0e6
https://research.rug.nl/en/publications/6095f442-6a44-4077-84c0-276c2a2ed0e6
Publikováno v:
Cancer Immunology, Immunotherapy. 48:419-420
Mice with a severe metastasized tumour burden can be cured with a single local injection of interleukin-2. Such a treatment can also be effective against ocular squamous cell carcinoma in cows and transmissible venereal tumours in dogs. We did not no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c55a7eda487ead82ff59826ed2d8a2
https://doi.org/10.1007/s002620050595
https://doi.org/10.1007/s002620050595