Zobrazeno 1 - 10
of 579
pro vyhledávání: '"J.-Y. Bonnefoy"'
Autor:
Alain Van Dorsselaer, Sergii Kolodych, J.-Y. Bonnefoy, Sarah Cianférani, Alain Wagner, Jitka Eberova, Zoljargal Baatarkhuu, Johann Stojko, Oleksandr Koniev
Publikováno v:
Bioconjugate Chemistry. 26:1863-1867
Thiols are among the most frequently used functional groups in the field of bioconjugation. While there exists a variety of heterobifunctional reagents that allow for coupling thiols to other functions (e.g., amines, carboxylic acids), there is no sp
Autor:
Sergii Kolodych, François Debaene, Alain Wagner, Alain Van Dorsselaer, J.-Y. Bonnefoy, Oleksandr Koniev, Zoljargal Baatarkhuu, Sarah Cianférani
Publikováno v:
Bioconjugate chemistry. 26(2)
Amine-to-thiol coupling is the most common route for the preparation of antibody–drug conjugates (ADC). It is usually achieved by using heterobifunctional reagents possessing an activated ester at one end and a maleimide group at the other. However
Autor:
Marie-Claire Bussat, Christine Klinguer-Hamour, L. Goetsch, Alain Beck, Jean-François Haeuw, J.-Y. Bonnefoy, J.-P. Aubry, T. Champion, E. Julien, Nathalie Corvaia
Publikováno v:
The Journal of Peptide Research. 57:528-538
Several cytotoxic T lymphocyte peptide-based vaccines against hepatitis B, human immunodeficiency virus and melanoma were recently studied in clinical trials. One interesting melanoma vaccine candidate alone or in combination with other tumor antigen
Autor:
J Y Bonnefoy, Jean-François Gauchat, Helene Plun-Favreau, Catherine Guillet, Hugues Gascan, A B de Coignac, I Suard, Josy-Anne Froger, Eric Lelièvre, Sylvie Chevalier, Greg Elson, Yves Delneste
Publikováno v:
Nature Neuroscience. 3:867-872
Ciliary neurotrophic factor (CNTF) is a cytokine supporting the differentiation and survival of various cell types in the peripheral and central nervous systems. Its receptor complex consists of a non-signaling alpha chain, CNTFR, and two signaling b
Publikováno v:
Biotechnology and Bioengineering. 69:351-358
Batch processes for recombinant gene expression in prokaryotic systems should optimally comprise a growth phase with minimal promoter activity followed by a short phase favoring expression. The strong promoter of the tryptophan operon (Ptrp) gives hi
Autor:
Nathalie Corvaia, A Van Dorsselaer, Nathalie Zorn, Alain Beck, Jean-François Haeuw, J.-Y. Bonnefoy, Thien Ngoc Nguyen, Marie-Claire Bussat
Publikováno v:
The Journal of Peptide Research. 55:24-35
Respiratory Syncytial Virus (RSV) is the most important cause of bronchiolitis and viral pneumonia in infants and young children. Approximately 100000 children are hospitalized in the USA each year as a result of RSV infections. During the research a
Autor:
P, Jeannin, N, Herbault, Y, Delneste, G, Magistrelli, S, Lecoanet-Henchoz, G, Caron, J P, Aubry, J Y, Bonnefoy
Publikováno v:
The Journal of Immunology. 162:2044-2048
The glycoprotein CD86 expressed on APCs provides a costimulatory signal necessary for an efficient activation of naive T cells. In contrast, there is controversy about the condition of expression and the function of CD86 on T cells. In this study, we
Publikováno v:
The Journal of Immunology. 160:3555-3561
Allergen-specific IgE plays a key role in the physiopathology of allergic disorders. This IgE response is usually accompanied by a production of IgG4. Indirect evidence suggests that IgG4 may not be a sensitizing Ab but, in contrast, could be protect
Autor:
J P Aubry, N Dugas, S Lecoanet-Henchoz, F Ouaaz, H Zhao, J F Delfraissy, P Graber, J P Kolb, B Dugas, J Y Bonnefoy
Publikováno v:
The Journal of Immunology. 159:614-622
CD23, a low-affinity receptor for IgE, was recently shown to bind to CD11b and CD11c molecules on human monocytes. The 25-kDa soluble fragment of CD23 (sCD23), was tested for its capacity to elicit various signaling pathways in human monocytes. sCD23
Autor:
J Galon, J F Gauchat, N Mazières, R Spagnoli, W Storkus, M Lötze, J Y Bonnefoy, W H Fridman, C Sautès
Publikováno v:
The Journal of Immunology. 157:1184-1192
The type III-B Fcgamma receptor (FcgammaRIII-B) is a glycosyl-phosphatidylinositol-linked receptor found on human neutrophils. A soluble form of FcgammaRIII-B (sCD16) corresponding to the extracellular region of the receptor circulates in plasma. In