Výsledky vyhledávání - "J.-P. Sommadossi"

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Fumagillin analog in the treatment of Kaposi's sarcoma: a phase I AIDS Clinical Trial Group study. AIDS Clinical Trial Group No. 215 Team

Autor: C W Suckow, J H Von Roenn, J Moore, S L Shriver, T W Cheung, Parkash S. Gill, Timothy P. Cooley, Bruce J. Dezube, Jeanne Holden-Wiltse, J P Sommadossi, Scot C. Remick

Publikováno v: Journal of Clinical Oncology. 16:1444-1449

PURPOSE Angiogenesis is a major component of Kaposi's sarcoma (KS) and a critical process in tumor growth. The present study was designed primarily to test the toxicity and pharmacokinetics (PK) of the angiogenesis inhibitor TNP-470 and secondarily t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b24149a756802ab0724bf378922ba6
https://doi.org/10.1200/jco.1998.16.4.1444

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Arabinogalactan (9kDa)-9-β-D-Arabinofuranosyladenine-5′-Monophosphate, A Novel Liver-Targeted Conjugate that Selectively Inhibits Hepatitis B virus Replication in Vitro

Autor: Abdesslem Faraj, Ev Groman, Am El Alaoui, Lixin Cui, J.-P. Sommadossi, Jv Rutkowski, Josephson L

Publikováno v: Antiviral Chemistry and Chemotherapy. 8:529-536

Arabinogalactan (9kDa)-9-β-D-arabinofuranosyladenine-5'-monophosphate [AG (9kDa)-araAMP] was 25-fold more active than the parent compound 9-β-D-arabinofuranosyladenine (araA) in decreasing the amount of hepatitis B virus (HBV) DNA intracellular rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55b39850952baa63d8424588e87e80b7
https://doi.org/10.1177/095632029700800606

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Comparison of Cytotoxicity of Mononucleoside Phosphotriester Derivatives Bearing Biolabile Phosphate Protecting Groups in Normal Human Bone Marrow Progenitor Cells

Autor: Anne-Marie Aubertin, André Kirn, Meng-Yu Xie, Gilles Gosselin, J.-P. Sommadossi, Jean Louis Imbach, Christian Périgaud, Jean-Luc Girardet, Isabelle Lefebvre

Publikováno v: Antiviral Chemistry and Chemotherapy. 7:338-345

The effects of three mononucleoside phosphotriester derivatives of 3′-azido-2′,3′-dideoxythymidine (AZT) which incorporate biolabile phosphate protecting groups, namely S-acetyl-2-thioethyl (MeSATE), S-(2-hydroxyethylsulfidyl)-2-thioethyl (DTE)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03d0bb12ee7242b85a832b99c8cb2c39
https://doi.org/10.1177/095632029600700607

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Inhibition of Hepatitis B Virus Replication by Nucleoside Enantiomers of β-2′,3′-Dideoxypurine Analogues

Autor: R. Johnson, Jean Louis Imbach, Claire Pierra, J.-P. Sommadossi, Abdesslem Faraj, Gilles Gosselin, Christophe Mathé, A.M. El Alaoui, V. Boudou, Brent E. Korba, Raymond F. Schinazi

Publikováno v: Antiviral Chemistry and Chemotherapy. 7:276-280

Various purine β-L-2′,3′-dideoxynucleoside analogues with both sugar and base modifications including β-L-ddG, β-L-ddl, β-L-ddA, 2′-azido-β-L-araddA, 2′-amino-β-L-araddA, 2′,5′-anhydro-β-L-araddA, 2′-azido-β-L-ddA, 2′-amino-β

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bea7b6687f1681ee213e16f2024549b2
https://doi.org/10.1177/095632029600700508

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Comparative kinetic analyses of interaction of inhibitors with Rauscher murine leukemia virus and human immunodeficiency virus reverse transcriptases

Autor: M A Ussery, S J Allen, Raymond F. Schinazi, Julie M. Cherrington, J P Sommadossi, Andrew Mulato, Michael D. Fuller, S C Kunder, Ming S. Chen, Z Lesnikowski

Publikováno v: Antimicrobial Agents and Chemotherapy. 40:1270-1273

The inhibitory effects of several nucleoside triphosphate analogs on Rauscher murine leukemia virus (RMuLV) and human immunodeficiency virus (HIV) type 1 reverse transcriptases (RTs) were studied. With RNA as the template, the apparent K(m) and appar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cfa7966c6b3a4e956d4793902c9d3e
https://doi.org/10.1128/aac.40.5.1270

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Protection and rescue from 2',3'-dideoxypyrimidine nucleoside analog toxicity by hemin in human bone marrow progenitor cells

Autor: J.-P. Sommadossi, Meng-Yu Xie, D A Fowler

Publikováno v: Antimicrobial Agents and Chemotherapy. 40:191-195

Long-term therapy of AIDS patients with 3'-azido-3'-deoxythymidine (AZT) remains of concern because of resulting hematopoietic toxicity. While the mechanism(s) of this toxicity remains elusive, alternative strategies are being developed to reduce the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b0f1a37889d9bd7e5781f49a71f4c0
https://doi.org/10.1128/aac.40.1.191

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