Maintaining and breaking symmetry in homomeric coiled-coil assemblies

Autor: Guto G. Rhys, Christopher W. Wood, Eric J. M. Lang, Adrian J. Mulholland, R. Leo Brady, Andrew R. Thomson, Derek N. Woolfson

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Higher order coiled coils with five or more helices can form α-helical barrels. Here the authors show that placing β-branched aliphatic residues along the lumen yields stable and open α-helical barrels, which is of interest for the rational design

Externí odkaz: https://doaj.org/article/5c02c52e40f94c5bb66b86f6007891f4

Multiscale Workflow for Modeling Ligand Complexes of Zinc Metalloproteins

Autor: Silvia Gervasoni, Eric J. M. Lang, Adrian J. Mulholland, Reynier Suardíaz, James Spencer, Charlotte K. Colenso, Zongfan Yang, Rebecca M. Twidale

Publikováno v: Yang, Z, Twidale, R M, Gervasoni, S, Suardíaz, R, Colenso, C K, Lang, E J M, Spencer, J & Mulholland, A J 2021, ' Multiscale Workflow for Modeling Ligand Complexes of Zinc Metalloproteins ', Journal of Chemical Information and Modeling, vol. 61, no. 11, pp. 5658-5672 . https://doi.org/10.1021/acs.jcim.1c01109

Zinc metalloproteins are ubiquitous, with protein zinc centers of structural and functional importance, involved in interactions with ligands and substrates and often of pharmacological interest. Biomolecular simulations are increasingly prominent in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59458a45589ff68f2d3ba1ccc3254d0a
https://doi.org/10.1021/acs.jcim.1c01109

The Disappearing Colorado River: Historic and Modern Attempts to Manage the Lifeline of the United States Southwest

Autor: Kenneth R. Olson, J. M. Lang

Publikováno v: Open Journal of Soil Science. 11:538-566

Historic Native American and modern civilizations have been forcing the unstable use of the Colorado River and adjacent land resources for centuries. Much can be learned from past Native American cultures that created irrigation systems to offset low

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f3440c29a99a60720015078fe05359f
https://doi.org/10.4236/ojss.2021.1111027

Polyimide dynamically compressed to decomposition pressures: Two-wave structures captured by velocimetry and modeling

Autor: R. C. Huber, D. M. Dattelbaum, J. M. Lang, Joshua D. Coe, J. H. Peterson, B. Bartram, L. L. Gibson

Publikováno v: Journal of Applied Physics. 133:035106

We performed a series of six plate impact experiments on polyimide and modeled them using new reactant and products equations of state combined with an Arrhenius rate model. The first experiment was diagnosed with embedded electromagnetic velocity ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b649bd87202fbabb5e413644355aeaf
https://doi.org/10.1063/5.0128515

Structural resolution of switchable states of a de novo peptide assembly

Autor: Christopher Williams, William M. Dawson, Adrian J. Mulholland, Matthew P. Crump, R. Leo Brady, Eric J. M. Lang, Kathryn L Shelley, Guto G. Rhys, Derek N. Woolfson

Publikováno v: Nature Communications
Dawson, W M, Lang, E J M, Rhys, G G, Shelley, K L, Williams, C, Brady, R L, Crump, M P, Mulholland, A J & Woolfson, D N 2021, ' Structural resolution of switchable states of a de novo peptide assembly ', Nature Communications, vol. 12, no. 1, 1530 (2020) . https://doi.org/10.1038/s41467-021-21851-8
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

De novo protein design is advancing rapidly. However, most designs are for single states. Here we report a de novo designed peptide that forms multiple α-helical-bundle states that are accessible and interconvertible under the same conditions. Usual

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4412c9b6d818e92335594445134d1004
http://europepmc.org/articles/PMC7943578