Zobrazeno 1 - 10
of 31
pro vyhledávání: '"J.-M. Hornsperger"'
Autor:
Daniel Schirlin, Debra L. Taylor, C. G. Bridges, P. S. Ahmed, J.-M. Hornsperger, Celine Tarnus, A. S. Tyms, V. Van Dorsselaer, T M Brennan
Publikováno v:
Antiviral Chemistry and Chemotherapy. 8:205-214
MDL 74,695, a novel dipeptide-like compound containing the ‘difluorostatone type’ transition state mimic and a potent inhibitor of the human immunodeficiency virus (HIV) proteinase, was investigated for anti-HIV activity in vitro. The compound sh
Autor:
J M Hornsperger, A. S. Tyms, J F Navé, C G Bridges, Debra Taylor, P Casara, P S Ahmed, T. M. Brennan
Publikováno v:
Antimicrobial Agents and Chemotherapy. 40:1072-1077
The novel acyclonucleotide derivative of guanine, 9-[2-methylidene-3-(phosphonomethoxy)propyl] guanine (MDL 74,968), had antiviral activity comparable to those of 9-(2-phosphonomethoxyethyl) adenine (PMEA) and 2',3'-dideoxyinosine against laboratory
Autor:
David A. Demeter, J. M. Hornsperger, R. D. Mcdermott, R. J. Broersma, Jeffrey P. Whitten, James R. McCarthy, Donald P. Matthews, P. R. Kastner, Herschel J. R. Weintraub
Publikováno v:
ChemInform. 22
Autor:
Jean-Bernard Ducep, Joseph Wagner, Daniel Schirlin, J. Fischer, J. M. Hornsperger, A. Mitschler, Raymond Weiss, Jean-Georges Heydt, Philippe Bey, Michel Jung, S. Baltzer, Charles Danzin, A. De Cian, F. Piriou
Publikováno v:
ChemInform. 23
The synthesis of α-(chlorofluoromethyl)-ornithine 7, -metatyrosine 8 and -glutamic acid 14 is described. Separation of diastereoisomers and relative configuration assignment by X-ray analysis are reported. Assignment of absolute configuration of the
Autor:
Joseph Wagner, Daniel Schirlin, Michel Jung, J. Fischer, J. M. Hornsperger, A. Mitschler, A. De Cian, Philippe Bey, F. Piriou, Jean-Bernard Ducep, S. Baltzer, Charles Danzin, Raymond Weiss, Jean-Georges Heydt
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :1053-1064
The synthesis of α-(chlorofluoromethyl)-ornithine 7, -metatyrosine 8 and -glutamic acid 14 is described. Separation of diastereoisomers and relative configuration assignment by X-ray analysis are reported. Assignment of absolute configuration of the
Autor:
J. M. Hornsperger, Rolf Jackisch, Bruno Will, Christian Kelche, Jean-Christophe Cassel, Georg Hertting
Publikováno v:
Brain Research. 534:295-298
Effects of aspirative fimbria-fornix lesions and intrahippocampal grafts of fetal septal-diagional band or hippocampal tissue were examined, in Long Evans female rats, on spontaneous alternation, radial maze learning, hippocampal acetylcholine concen
Publikováno v:
Arzneimittel-Forschung. 45(12)
MDL 73,745 (2,2,2-trifluoro-1-(3-trimethylsilylphenyl) ethanone, CAS 132236(18-1) is a novel tight-binding inhibitor of acetylcholinesterase (AChE), which is in development as a potential therapeutic compound in the symptomatic treatment of Alzheimer
Autor:
M. H. Richards, Bruno Will, Christian Kelche, J. M. Hornsperger, Georg Hertting, Rolf Jackisch, M. Duschek, Jean-Christophe Cassel
Publikováno v:
Experimental brain research. 83(3)
Long Evans female rats sustained aspirative lesions of the septohippocampal pathways; subsequently, they received intrahippocampal suspension grafts of fetal septal-diagonal band or hippocampal tissue. The long term (8–10 months post-surgery) effec
Autor:
J. M. Hornsperger, J. M. Meyer
Publikováno v:
Journal of General Microbiology. 107:329-331
Uptake experiments with 59Fe3+ showed that Pseudomonas fluorescens had an active system for iron transport. When the purified iron-binding pigment synthesized by this bacterium was added to the external medium, the rate of iron uptake by the cells in
Publikováno v:
ChemInform. 19