Integrated genomic analysis reveals aberrations in WNT signaling in germ cell tumors of childhood and adolescence

Autor: Lin Xu, Joshua L. Pierce, Angelica Sanchez, Kenneth S. Chen, Abhay A. Shukla, Nicholas J. Fustino, Sarai H. Stuart, Aditya Bagrodia, Xue Xiao, Lei Guo, Mark D. Krailo, Furqan Shaikh, Deborah F. Billmire, Farzana Pashankar, Jessica Bestrashniy, J. Wolter Oosterhuis, Ad J. M. Gillis, Yang Xie, Lisa Teot, Jaume Mora, Jenny N. Poynter, Dinesh Rakheja, Leendert H. J. Looijenga, Bruce W. Draper, A. Lindsay Frazier, James F. Amatruda

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

Abstract Germ cell tumors (GCTs) are neoplasms of the testis, ovary and extragonadal sites that occur in infants, children, adolescents and adults. Post-pubertal (type II) malignant GCTs may present as seminoma, non-seminoma or mixed histologies. In

Externí odkaz: https://doaj.org/article/7de0ec00eddb4344af90c7a9512816da

Prediction of relapse in stage I testicular germ cell tumor patients on surveillance: investigation of biomarkers

Autor: João Lobo, Ad J. M. Gillis, Annette van den Berg, Leendert H. J. Looijenga

Publikováno v: BMC Cancer, Vol 20, Iss 1, Pp 1-16 (2020)

Abstract Background Better biomarkers for assessing risk of relapse in stage I testicular germ cell tumor patients are needed, to complement classical histopathological variables. We aimed to assess the prognostic value of previously suggested biomar

Externí odkaz: https://doaj.org/article/7a60a5d7d3f44e7b9116ea0a57f6e63f

Paclitaxel, Ifosfamide, and Cisplatin in Patients with Poor-prognosis Disseminated Nonseminomatous Germ Cell Tumors with Unfavorable Serum Tumor Marker Decline After First Cycle of Chemotherapy. The GCT-SK-003 Phase II Trial

Autor: Zuzana Sycova-Mila, Leendert H. J. Looijenga, Michal Chovanec, Vera Miskovska, Maria Reckova, Daniela Svetlovska, Jana Obertova, Valentina De Angelis, Patrik Palacka, Michal Mego, Katarina Rejlekova, Jozef Mardiak, Katarina Kalavska, Ad J. M. Gillis, Daniel Pindak

Publikováno v: European Urology Open Science, Vol 33, Iss, Pp 19-27 (2021)
European Urology Open Science

Background Germ cell tumors represent highly curable disease even in metastatic stage. However, poor-risk patients with an unfavorable serum tumor marker (STM) decline after the first cycle of chemotherapy represent a subgroup with dismal prognosis,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa68ffb871427c0cb6d2186b7958b89
http://www.sciencedirect.com/science/article/pii/S2666168321006716

Whole-genome sequencing of spermatocytic tumors provides insights into the mutational processes operating in the male germline.

Autor: Eleni Giannoulatou, Geoffrey J Maher, Zhihao Ding, Ad J M Gillis, Lambert C J Dorssers, Alexander Hoischen, Ewa Rajpert-De Meyts, WGS500 Consortium, Gilean McVean, Andrew O M Wilkie, Leendert H J Looijenga, Anne Goriely

Publikováno v: PLoS ONE, Vol 12, Iss 5, p e0178169 (2017)

Adult male germline stem cells (spermatogonia) proliferate by mitosis and, after puberty, generate spermatocytes that undertake meiosis to produce haploid spermatozoa. Germ cells are under evolutionary constraint to curtail mutations and maintain gen

Externí odkaz: https://doaj.org/article/5ee5601fc0c34d3a8a8086765dae2fc3

Combining Hypermethylated RASSF1A Detection Using ddPCR with miR-371a-3p Testing: An Improved Panel of Liquid Biopsy Biomarkers for Testicular Germ Cell Tumor Patients

Autor: Ad J. M. Gillis, João Lobo, Mohammed Gussmalla Nuru, Leendert H. J. Looijenga, Lieke M. J. van Zogchel, C. Ellen van der Schoot, Godelieve A.M. Tytgat

Publikováno v: Cancers, Vol 13, Iss 5228, p 5228 (2021)
Cancers
Volume 13
Issue 20
Cancers, 13(20):5228. Multidisciplinary Digital Publishing Institute (MDPI)

Simple Summary Testicular germ cell tumors are the most common solid cancers in men aged between 15–39 years. There is a need of non-invasive biomarkers for diagnosis and follow-up of these patients. miR-371a-3p has emerged as the most reliable bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b350987709f7749f27668a080b2ffdce
https://www.mdpi.com/2072-6694/13/20/5228