Výsledky vyhledávání - "J.-L. Imbach"

Akademický článek

Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate

Autor: J. L. Imbach, J. L. Barascut, H. B. Lazrek, M. Taourirte, A. Rochdi

Publikováno v: Molecules, Vol 5, Iss 10, Pp 1139-1145 (2000)

The E- and Z- phosphonoalkenyl acyclonucleosides of uracil and thymine were synthesized under Michael addition conditions. Introduction of an alkyl, alkenyl or alkynyl group at the N-3 position of the pyrimidine moiety was accomplished using potassiu

Externí odkaz: https://doaj.org/article/694eee5d484f403bb95cfcd81bb8627e

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Influence of a Cα-Substitution on the S-Pivaloyl-2-Thioethyl Chain on the Anti-HIV Activity and Stability of the Resulting Zidovudine Mononucleoside Phosphotriester

Autor: Suzanne Peyrottes, Gilles Gosselin, Christian Périgaud, A-M Aubertin, J-L Imbach

Publikováno v: Antiviral Chemistry and Chemotherapy. 12:223-232

We report the synthesis, in vitro anti-HIV-1 activity and stability study of a mononucleoside phosphotriester derivative of 3′-azido-2′,3′-dideoxythymidine (AZT) bearing a new biolabile phosphate-protection, namely S-pivaloyl-2-thioisopropyl (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4acded30702adf41c81f9d6ecbcaa2
https://doi.org/10.1177/095632020101200403

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Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate

Autor: M. Taourirte, J.-L. Imbach, A. Rochdi, J. L. Barascut, Hassan B. Lazrek

Publikováno v: Molecules, Vol 5, Iss 10, Pp 1139-1145 (2000)
Molecules
Volume 5
Issue 10
Pages 1139-1145

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f9a195dd143a98eb13a7e1bcb535fa
http://www.mdpi.com/1420-3049/5/10/1139/

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DDC- and 3TC-bis(SATE) Monophosphate Prodrugs Overcome Cellular Resistance Mechanisms to HIV-1 Associated with Cytidine Kinase Deficiency

Autor: B. Gröschel, N. Himmel, J. Cinatl, C. Périgaud, G. Gosselin, J-L. Imbach, H. W. Doerr

Publikováno v: Nucleosides and Nucleotides. 18:921-926

A 2',3'-dideoxycytidine (ddC)-resistant T-lymphoid cell line (MOLT-4/8rddC250), in which deoxycytidine kinase (dCK) gene-expression was decreased when compared with parental cells, has been selected. Cytotoxic and antiretroviral activity of ddC and 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad00fe7ae823943a3faab2fd69d584b2
https://doi.org/10.1080/15257779908041600

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Human Immunodeficiency Virus Resistance to AZT in MOLT4/8 Cells is Associated with a Lack of AZT Phosphorylation and is Bypassed by AZT-Monophosphate SATE Prodrugs

Autor: J Cinatl, B Gröschel, R Zehner, C Périgaud, G Gosselin, J-L Imbach, HW Doerr

Publikováno v: Antiviral Chemistry and Chemotherapy. 8:343-352

Human T lymphoid MOLT4/8 cells were grown continuously for more than 2 years in a medium containing 3′-azido-2′,3′-dideoxythymidine (zidovudine; AZT) at a concentration of 250 μM. These cells, designated MOLT-4/8rAZT250, were used to test the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e5ddc09849c186426f386f3513ba41d
https://doi.org/10.1177/095632029700800407

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In vitro inhibition of hepatitis C virus gene expression by chemically modified antisense oligodeoxynucleotides

Autor: J L Imbach, M E Major, C. Trepo, B Rayner, O. Vidalin, Geneviève Inchauspe

Publikováno v: Antimicrobial Agents and Chemotherapy. 40:2337-2344

We have explored different domains within the hepatitis C virus (HCV) 5' noncoding region as potential targets for inhibition of HCV translation by antisense oligodeoxynucleotides (ODNs). Inhibition assays were performed with two different cell-free

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de82b147ce0fcd4e641987443839c21a
https://doi.org/10.1128/aac.40.10.2337

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Decomposition Pathways and in Vitro HIV Inhibitory Effects of IsoddA Pronucleotides: Toward a Rational Approach for Intracellular Delivery of Nucleoside 5‘-Monophosphates

Autor: C. Perigaud, A. Pompon, J.-L. Imbach, Loredana Cappellacci, Palmarisa Franchetti, G. Valette, P. La Colla, G. Gosselin, A. G. Loi, Mario Grifantini, J.-L. Girardet

Publikováno v: Journal of Medicinal Chemistry. 39:1981-1990

The decomposition pathways and kinetics in various biological media and the in vitro anti-HIV-1 and anti-HIV-2 activities of four derivatives of the 5'-mononucleotide of isoddA incorporating carboxylate esterase-labile transient phosphate protecting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb2364031eb0006dd954a4400547307
https://doi.org/10.1021/jm9507338

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Increase of the anti-HIV activity of D4T in human T-cell culture by the use of the sate pronucleotide approach

Autor: Gilles Gosselin, Christian Périgaud, André Kirn, J.‐L. Imbach, Anne-Marie Aubertin, Jean-Luc Girardet

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:2981-2984

The bis( S -acetyl-2-thioethyl) phosphotriester derivative of 2′,3′-didehydro-2′,3′-dideoxythymidine has been synthesized and evaluated for its inhibitory effects on the replication of HIV-1 in several cell culture systems. This pronucleotide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21f669d03de36579aabeefc3ecc7ff41
https://doi.org/10.1016/0960-894x(95)00525-7

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Synthesis of Acycloalkenyl Derivatives of Pyrimidines and Purines

Autor: J.-L. Imbach, A. Rochdi, J. L. Barascut, N. Redwane, Hassan B. Lazrek, E. De Clercq

Publikováno v: Nucleosides, Nucleotides and Nucleic Acids. 14:353-356

Conjugate addition of an anionic nucleophile (nucleobase) to an active triple bond (α, β unsaturated carboxylate or phosphonate) was used for preparing α-ethenyl carboxylate or phosphonate derivatives of purines and pyrimidines.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f42f89355e55374252fdffc3ae9db8f4
https://doi.org/10.1080/15257779508012380

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A New Synthesis of Some 4′-Thio-D-ribonucleosides and Preliminary Enzymatic Evaluation

Autor: L. Bellon, H. Pelicano, Georges Maury, J. Deydier, C. Leydier, J. L. Barascut, M. A. El Alaoui, J.‐L. Imbach

Publikováno v: Nucleosides and Nucleotides. 13:2035-2050

A new synthesis of 4′-thioribonucleosides is presented together with the enzymatic evaluation of the adenosine analogues with respect to adenosine kinase. The 4-thio-D-ribofuranosyl carbohydrate precursor 7 was obtained in good yield from D-ribose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f352c408ae027e7e426ff83556fe830
https://doi.org/10.1080/15257779408013205

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