Zobrazeno 1 - 10
of 39
pro vyhledávání: '"J.-F. Patoiseau"'
Publikováno v:
Journal of Cardiovascular Pharmacology. 26:803-809
Action potential duration (APD) lengthening is believed to underlie the cardiac arrhythmogenicity of ketanserin, a serotonin (5-HT)2A/2C receptor antagonist. We wished to determine (a) whether this activity involves blockade of 5-HT2A/2C receptors an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59513a3ae982bb5942d4c2e75fa1134f
https://doi.org/10.1097/00005344-199511000-00018
https://doi.org/10.1097/00005344-199511000-00018
Publikováno v:
British Journal of Pharmacology. 112:195-199
1. The putative direct protective effects of a series of chemically diverse alpha 1-adrenoceptor antagonists against veratrine alkaloid-induced tetanic contractures in rat isolated left atria have been investigated. 2. Atria were mounted in organ bat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a18c1e220eb15751a52a2743671e550
https://doi.org/10.1111/j.1476-5381.1994.tb13051.x
https://doi.org/10.1111/j.1476-5381.1994.tb13051.x
Autor:
A. Marty, A. M. Bessac, J. Tisne-Versailles, J. P. Rieu, J. F. Patoiseau, D. C. H. Bigg, A. Duflos, R. Bonnafous, Y. Verscheure, J. C. Tristani
Publikováno v:
European Journal of Medicinal Chemistry. 28:683-691
A series of 2,3-dihydro-4 H -1,3-benzoxazin-4-ones substituted at the 3-position with an arylalkyaminoalkyl group have been synthesized and their specific bradycardic and antiarrythmic activities evaluated. Bradycardia is optimal when the aromatic ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4daf631260569b86987f8f27e0708c89
https://doi.org/10.1016/0223-5234(93)90027-c
https://doi.org/10.1016/0223-5234(93)90027-c
Publikováno v:
ChemInform. 23
The reaction of a number of γ-butyrolactones with azole anions is shown to give γ-substituted butanoic acids in moderate to good yields. The pyrrolyl and indolylbutanoic acids obtained underwent cyclization in a simple one-pot procedure employing e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb89052b6e940d03c4099f2ab14e0256
https://doi.org/10.1002/chin.199220160
https://doi.org/10.1002/chin.199220160
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b191567668fc9f0b875a4739893f32d6
https://doi.org/10.1002/chin.199211146
https://doi.org/10.1002/chin.199211146
Autor:
J. F. Patoiseau, D. C. H. Bigg, A. Duflos, J. C. Tristani, R. Bonnafous, J. P. Rieu, A. M. Bessac, A. Marty, Y. Verscheure, J. Tisne-Versailles
Publikováno v:
ChemInform. 25
A series of 2,3-dihydro-4 H -1,3-benzoxazin-4-ones substituted at the 3-position with an arylalkyaminoalkyl group have been synthesized and their specific bradycardic and antiarrythmic activities evaluated. Bradycardia is optimal when the aromatic ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb3f5598deb5f675f9ae83b374c07743
https://doi.org/10.1002/chin.199404190
https://doi.org/10.1002/chin.199404190
Publikováno v:
Journal of Heterocyclic Chemistry. 28:1927-1932
The reaction of a number of γ-butyrolactones with azole anions is shown to give γ-substituted butanoic acids in moderate to good yields. The pyrrolyl and indolylbutanoic acids obtained underwent cyclization in a simple one-pot procedure employing e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f454f6e8f3baeb05f9856208cd58ab1
https://doi.org/10.1002/jhet.5570280820
https://doi.org/10.1002/jhet.5570280820
Publikováno v:
Tetrahedron. 47:9629-9640
Lactone I is an important intermediate in the synthesis of compounds with therapeutic properties. In order to prepare new derivatives, reactivity of I has been studied. Cis and trans conformations of both 2,3-diphenyl-1-oxabicyclo [3,1,0] hexanes VII
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6d994fbe43df4491fb2547d7487bd0f
https://doi.org/10.1016/s0040-4020(01)91029-4
https://doi.org/10.1016/s0040-4020(01)91029-4
Autor:
J P, Ribet, R, Pena, A, Chauvet, J F, Patoiseau, J M, Autin, R, Segonds, M, Basquin, J M, Autret
Publikováno v:
Annales pharmaceutiques francaises. 60(3)
The importance, in therapeutics, of the concept of bioavailability and on-going quality research in the formulation of a drug has prompted us to examine the crystalline polymorphism of eflucimibe as from the research phase. This study has been carrie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3003f79513574a5a5a4ae4b04690937b
https://pubmed.ncbi.nlm.nih.gov/12050596
https://pubmed.ncbi.nlm.nih.gov/12050596
Autor:
D, Junquero, A, Pilon, E, Carilla-Durand, J F, Patoiseau, J P, Tarayre, G, Torpier, B, Staels, J C, Fruchart, F C, Colpaert, V, Clavey, A, Delhon
Publikováno v:
Biochemical pharmacology. 61(4)
Inhibition of acyl-coenzyme A: cholesterol O-acyltransferase (EC 2.3.1.26; ACAT) reduces intracellular cholesteryl esters that are substrates for steroidogenesis in adrenal cells. The adrenal side effects of ACAT inhibitors remain a key point for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2c0c382d7022328c378728061c088d5e
https://pubmed.ncbi.nlm.nih.gov/11226372
https://pubmed.ncbi.nlm.nih.gov/11226372