Increased frequency of proangiogenic tunica intima endothelial kinase 2 (Tie2) expressing monocytes in individuals with type 2 diabetes mellitus

Autor: M. Reijrink, J. van Ark, C. P. H. Lexis, L. M. Visser, M. E. Lodewijk, I. C. C. van der Horst, C. J. Zeebregts, H. van Goor, S. C. A. de Jager, G. Pasterkamp, B. H. R. Wolffenbuttel, J. L. Hillebrands

Publikováno v: Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-16 (2022)

Abstract Background Individuals with type 2 diabetes mellitus (T2DM) have an increased risk for developing macrovascular disease (MVD) manifested by atherosclerosis. Phenotypically and functionally different monocyte subsets (classical; CD14++CD16−

Externí odkaz: https://doaj.org/article/cef05e3232a645d6b6518792a3d96aef

Anxiety, memories and coping in patients undergoing intracranial tumor surgery

Autor: Arnaud J P E Vincent, Markus Klimek, Tom J. van Ark, Peter P de Smalen, Robert Jan Stolker

Publikováno v: Clinical Neurology & Neurosurgery, 170, 132-139. Elsevier

Objectives The diagnosis and the surgical removal of a brain tumor can have serious impact on the quality of life of a patient. The question rises, whether having more or just less memories of the procedure is better for coping with such an event. Fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750cffc16ef172ea77a83928063553cf
https://pure.eur.nl/en/publications/ad8052ed-8e44-43e4-85a7-eda920752c12

Bone marrow-derived myofibroblasts contribute functionally to scar formation after myocardial infarction

Autor: Arend Petersen, Marco Harmsen, van Gooitzen Dam, George Bou-Gharios, van Marja Luyn, M. J. Van Amerongen, J. van Ark, Eliane R. Popa

Publikováno v: JOURNAL OF PATHOLOGY, 214(3), 377-386. Wiley

Myofibroblasts play a major role in scar formation during wound healing after myocardial infarction (MI). Their origin has been thought to be interstitial cardiac fibroblasts. However, the bone marrow (BM) can be a source of myofibroblasts in a numbe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f216388681f788859f490b6a5c0c81
https://research.rug.nl/en/publications/8324ad62-aacf-4343-9c33-35e7b642fc32

Characterization of human soft-tissue sarcoma xenografts for use in secondary drug screening

Autor: Peter G. Scheffer, Wilbert H.M. Peters, Hennie M.M. Schlüper, C. A. M. Erkelens, A. H. Van Hattum, Epie Boven, C. M. Kuiper, G. Giaccone, H.M. Pinedo, J. van Ark-Otte

Publikováno v: Scopus-Elsevier
British Journal of Cancer

We have established ten transplantable human soft-tissue sarcoma (STS) xenografts grown as subcutaneous tumours in the nude mouse. Nine xenografts originated from patients that needed chemotherapy in the course of their disease. The xenografts were t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82838ffa9a17f0bd4c8ad030cf949779
https://doi.org/10.1038/bjc.1998.727

Effects of suramin on human lung cancer cell lines

Autor: H.M. Pinedo, J. Virizuela, G. Rubio, J. van Ark-Otte, G. Giaccone

Publikováno v: European Journal of Cancer, 31A(2), 244-251. Pergamon
Rubio, G J, Pinedo, H M, Virizuela, J, van Ark-Otte, J & Giaccone, G 1995, ' Effects of suramin on human lung cancer cell lines ', European Journal of Cancer, vol. 31A, no. 2, pp. 244-251 .

Suramin cytotoxicity was studied in a panel of human lung cancer cell lines by the MTT assay. The concentrations of suramin which induced 50% growth inhibition (IC50) ranged from 130 to 3715 microM for the cell lines growing in medium containing 10%

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145ed95ac67cc92693fdace2c577064e
https://doi.org/10.1016/0959-8049(94)00444-a