MCART1 is required for mitochondrial NAD transport

Autor: M. Guera, Nora Kory, Caroline A. Lewis, Sze Ham Chan, N. Arp, N. Jankovic, Gyan Prakash, S. van der Rijt, Izabella A. Pena, Tenzin Kunchok, J. uit de Bos, David M. Sabatini

The nicotinamide adenine dinucleotide (NAD+/NADH) pair is a cofactor in redox reactions and is particularly critical in mitochondria as it connects substrate oxidation by the tricarboxylic acid (TCA) cycle to ATP generation by the electron transport

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8addbabde904852d8bbc31dd133649b3
https://doi.org/10.1101/2020.08.28.267252

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SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism.

Autor: Kory N; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Department of Biology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, 415 Main Street, Cambridge, MA 02142, USA., Wyant GA; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Department of Biology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, 415 Main Street, Cambridge, MA 02142, USA., Prakash G; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA., Uit de Bos J; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA., Bottanelli F; Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA., Pacold ME; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Department of Biology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, 415 Main Street, Cambridge, MA 02142, USA.; Department of Radiation Oncology at NYU Langone Medical Center, New York, NY 10016, USA., Chan SH; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA., Lewis CA; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA., Wang T; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Department of Biology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, 415 Main Street, Cambridge, MA 02142, USA., Keys HR; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA., Guo YE; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA., Sabatini DM; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA. sabatini@wi.mit.edu.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Department of Biology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, 415 Main Street, Cambridge, MA 02142, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2018 Nov 16; Vol. 362 (6416).