Zobrazeno 1 - 10
of 53
pro vyhledávání: '"J. Zingaro"'
Autor:
Haifeng Tang, Zack Zhiqiang Guo, Lee-Yuh Pai, Adam B. Weinglass, Xin Gu, Shuzhi Dong, Alexander Pasternak, Yang Yu, Kathleen A. Sullivan, Mengwei Hu, Kelsey VanGelder, Gloria J. Zingaro, Sophie Roy, Jessica Liu, Qinghong Fu, Birgit T. Priest, Michael Margulis, Brande Thomas-Fowlkes, Pierre Morissette, Robin E. Haimbach, Zhicai Wu, Juliann Ehrhart, Karen Owens, Caryn Hampton, Zhi-Cai Shi, Jessica Frie, Ron Ferguson, Shiyao Xu, Vincent Tong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2559-2566
SAR in the previously described spirocyclic ROMK inhibitor series was further evolved from lead 4 by modification of the spirocyclic core and identification of novel right-side pharmacophores. In this process, it was discovered that the spiropyrrolid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2dc6104dc29c3168c501b413896773
https://doi.org/10.1016/j.bmcl.2017.03.086
https://doi.org/10.1016/j.bmcl.2017.03.086
Autor:
A. Galijatovic-Idrizbegovic, S. O'Sullivan, H. Schuck, K.A. Bustard, Alysia A. Chaves, Richard Briscoe, M.A. Yordy, C.M. Hoe, D.B. Christian, Gloria J. Zingaro
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 56:103-114
Introduction Preclinical evaluation of delayed ventricular repolarization manifests electrocardiographically as QT interval prolongation and is routinely used as an indicator of potential risk for pro-arrhythmia (potential to cause Torsades de Pointe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e294616ed6bfcec3f6fed7fbbf3ab4a
https://doi.org/10.1016/j.vascn.2007.04.007
https://doi.org/10.1016/j.vascn.2007.04.007
Autor:
J. Zingaro, R. Chris Clarke, J.C. Golombeck, Andre Berghmans, Tracy Wait, Hong Zhang, Narsingh B. Singh
Publikováno v:
Journal of Crystal Growth. 250:107-112
Single crystals of aluminum nitride were grown by physical vapor transport (PVT) method. Evaluation of transport conditions was carried out during bulk growth of aluminum nitride in a vertical, cylindrical geometry. Experiments were carried out for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::448631b66af54e2b3367d0cd80ab0f6f
https://doi.org/10.1016/s0022-0248(02)02235-2
https://doi.org/10.1016/s0022-0248(02)02235-2
The anesthetized guinea pig: an effective early cardiovascular derisking and lead optimization model
Autor:
Jeffrey Travis, Chao-Min Hoe, Joseph J. Salata, Gloria J. Zingaro, Matthew M. Zrada, Pamela Gerenser, Armando Lagrutta, John Imredy, Elena Trepakova, Alysia A. Chaves, Greg Friedrichs, Masahiro Nishida, Kimberly M. Hoagland, Pierre Morissette
Publikováno v:
Journal of pharmacological and toxicological methods. 68(1)
Introduction In recent years, the anesthetized guinea pig has been used increasingly to evaluate the cardiovascular effects of drug-candidate molecules during lead optimization prior to conducting longer, more resource intensive safety pharmacology a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7569c48d2bd153328a78b217dbd0f5d
https://pubmed.ncbi.nlm.nih.gov/23649000
https://pubmed.ncbi.nlm.nih.gov/23649000
Autor:
Theodore P. Broten, William J. Greenlee, Robert A. Gabel, Nathan B. Mantlo, Peter K. S. Siegl, Debra Ondeyka, Salah D. Kivlighn, Raymond S.L. Chang, Gloria J. Zingaro, Raymond E. Gibson
Publikováno v:
European Journal of Pharmacology. 294:439-450
L-163,017 (6-[benzoylamino]-7-methyl-2-propyl-3-[(2′-(N-(3-methyl-1-butoxy)carbonylaminosulfonyl)[1,1′]-biphenyl-4-yl]-methyl]-3H-imidazo-[4,5-b] is a potent, orally active, nonpeptide angiotensin II receptor antagonist. Conscious rats and dogs w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bee47301c887cc474cb3e85ad342b77
https://doi.org/10.1016/0014-2999(95)00564-1
https://doi.org/10.1016/0014-2999(95)00564-1
Autor:
Stephen E. de Laszlo, Raymond S. Chang, Tsing-Bau Chen, Kristie A. Faust, William J. Greenlee, Salah D. Kivlighn, Victor J. Lotti, Stacey S. O'Malley, Terry W. Schorn, Peter K. Siegl, Jennifer Tran, Gloria J. Zingaro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1359-1364
Modification of the 6-N-alkyl-N-acyl groups of L-159,689, 6 6-(N-benzoyl-N-pentyl)-amino-2-propyl-3-[(2′-(tetrazol-5-yl)biphen-4-yl)methyl]quinazolin-4-(3H)one led to the identification of the 6-(N-benzoyl-N-(3-pyridylmethyl)) analog (L-162,537). L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0a634555cb07627e9316d3c58e22ecc
https://doi.org/10.1016/0960-894x(95)00224-h
https://doi.org/10.1016/0960-894x(95)00224-h
Autor:
Peter K. S. Siegl, Salah D. Kivlighn, Gloria J. Zingaro, Tsing-Bau Chen, Kristie A. Faust, Victor J. Lotti, William J. Greenlee, Arthur A. Patchett, Thomas F. Walsh, Kenneth J. Fitch, Raymond S.L. Chang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1151-1154
Directed synthesis and pharmacological evaluation in a recently described class of α-phenoxyphenylacetic acid bearing angiotensin II (AII) receptor antagonists has afforded further potent AT 1 -selective AII antagonists. Substitution in the central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ac6208c532d72a61e408771fa3545d7
https://doi.org/10.1016/0960-894x(95)00185-v
https://doi.org/10.1016/0960-894x(95)00185-v
Autor:
Robert A. Gabel, Theodore P. Broten, Gloria J. Zingaro, Linda W. Schaffer, Peter K. S. Siegl, Arthur A. Patchett, Terry W. Schorn, William J. Greenlee, Prasun K. Chakravarty, Elizabeth M. Naylor, Salah D. Kivlighn
Publikováno v:
American Journal of Hypertension. 8:58-66
MK-996, N-(4'-(5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridin-3-yl- methyl)1,1'-biphenyl-2-yl)-sulfonylbenzamide, is a potent, orally active, highly selective, nonpeptide angiotensin II (AII) receptor antagonist. MK-996 prevents the pressor response t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f55083766855f91ccf77204abbefbc5
https://doi.org/10.1016/0895-7061(94)00169-c
https://doi.org/10.1016/0895-7061(94)00169-c
Autor:
Salah D. Kivlighn, Kenneth J. Fitch, W.J. Greenlee, T. F. Walsh, Peter K. S. Siegl, R. S. L. Chang, Kristie A. Faust, Arthur A. Patchett, Tsing-Bau Chen, Victor J. Lotti, Gloria J. Zingaro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:155-158
A series of nonpeptidic AT1 selective angiotensin II (AII) antagonists containing a phenoxyphenylacetic acid element as a biphenyl tetrazole replacement have been identified. This series yielded compound 20 which exhibited binding affinities of AT1 =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fdc507efde0eace8587fa3c1b7d5d9e
https://doi.org/10.1016/0960-894x(94)00476-v
https://doi.org/10.1016/0960-894x(94)00476-v
Autor:
Ralph A. Rivero, Peter K. S. Siegl, K. L. Flanagan, Salah D. Kivlighn, Wallace T. Ashton, Gloria J. Zingaro, Tsing-Bau Chen, Victor J. Lotti, R. S. L. Chang, S. S. O'malley, W.J. Greenlee, Linda L. Chang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2787-2792
A series of subnanomolar (IC50 triazolinone-based AT1/AT2-balanced AII antagonists has been identified. The 70-240-fold gain in AT2 activity relative to prototype compounds was achieved by the introduction of a 5-acylamino group on the N2-aryl moiety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7833c612680e51d2bc1ae919ba3ffd73
https://doi.org/10.1016/s0960-894x(01)80595-3
https://doi.org/10.1016/s0960-894x(01)80595-3