Regulation of stress granule formation in human oligodendrocytes

Autor: Florian Pernin, Qiao-Ling Cui, Abdulshakour Mohammadnia, Milton G. F. Fernandes, Jeffery A. Hall, Myriam Srour, Roy W. R. Dudley, Stephanie E. J. Zandee, Wendy Klement, Alexandre Prat, Hannah E. Salapa, Michael C. Levin, G. R. Wayne Moore, Timothy E. Kennedy, Christine Vande Velde, Jack P. Antel

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract Oligodendrocyte (OL) injury and subsequent loss is a pathologic hallmark of multiple sclerosis (MS). Stress granules (SGs) are membrane-less organelles containing mRNAs stalled in translation and considered as participants of the cellular re

Externí odkaz: https://doaj.org/article/7ecd4f332096485d86164c4aeb9e24fc

Identification of astrocyte regulators by nucleic acid cytometry

Autor: Iain C. Clark, Michael A. Wheeler, Hong-Gyun Lee, Zhaorong Li, Liliana M. Sanmarco, Shravan Thaploo, Carolina M. Polonio, Seung Won Shin, Giulia Scalisi, Amy R. Henry, Joseph M. Rone, Federico Giovannoni, Marc Charabati, Camilo Faust Akl, Dulce M. Aleman, Stephanie E. J. Zandee, Alexandre Prat, Daniel C. Douek, Eli A. Boritz, Francisco J. Quintana, Adam R. Abate

Publikováno v: Nature, vol 614, iss 7947
Nature

Multiple sclerosis is a chronic inflammatory disease of the central nervous system1. Astrocytes are heterogeneous glial cells that are resident in the central nervous system and participate in the pathogenesis of multiple sclerosis and its model expe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4aa6e11d1866a7910d272fce76dd090
https://doi.org/10.1038/s41586-022-05613-0

Droplet-based forward genetic screening of astrocyte–microglia cross-talk

Autor: Michael A. Wheeler, Iain C. Clark, Hong-Gyun Lee, Zhaorong Li, Mathias Linnerbauer, Joseph M. Rone, Manon Blain, Camilo Faust Akl, Gavin Piester, Federico Giovannoni, Marc Charabati, Joon-Hyuk Lee, Yoon-Chul Kye, Joshua Choi, Liliana M. Sanmarco, Lena Srun, Elizabeth N. Chung, Lucas E. Flausino, Brian M. Andersen, Veit Rothhammer, Hiroshi Yano, Tomer Illouz, Stephanie E. J. Zandee, Carolin Daniel, David Artis, Marco Prinz, Adam R. Abate, Vijay K. Kuchroo, Jack P. Antel, Alexandre Prat, Francisco J. Quintana

Publikováno v: Science

Cell–cell interactions in the central nervous system play important roles in neurologic diseases. However, little is known about the specific molecular pathways involved, and methods for their systematic identification are limited. Here, we develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716c964e8fd9ff8c09dd7ebbf702e31d
https://europepmc.org/articles/PMC10066924/

The role of complex IV activity in the axonal response of mitochondria to demyelination in experimental disease models of multiple sclerosis

Autor: Graham R. Campbell, Arpan R Metha, Yolanda S. Kap, Daniel Altman, Chao Zhao, David Baker, Stephen M. Anderton, Siddharthan Chandran, Katie McGill, Kenneth Smith, Bruce D. Trapp, Hans Lassmann, Jon D. Laman, Bert A t'Hart, Moses Rodriguez, Don J. Mahad, Stephanie E J Zandee, Robin J.M. Franklin, Sarah Al-Azki, Simon Licht-Mayer, Markus Kipp, Alex Symonds, Gareth Pryce

Axon loss is a cardinal neuropathological feature of multiple sclerosis (MS). Axonal injury in MS and experimental disease models is most frequently detected in acutely demyelinating regions. Furthermore, acute axonal injury consistently correlates w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d200d032d9cb001e6fcf387053783b5
https://doi.org/10.1101/2021.09.27.461926

Enhanced axonal response of mitochondria to demyelination offers neuroprotection: implications for multiple sclerosis

Autor: Arpan R Mehta, Niels Menezes, Ralf Watzlawick, Stephen M. Anderton, Hans Lassmann, David Baker, Angus B. Gane, Marco Canizares, Don J. Mahad, Jon D. Laman, Kenneth Smith, Bert A. 't Hart, Graham R. Campbell, Siddharthan Chandran, Gareth Pryce, Jasmine Dean, Simon Licht-Mayer, Alexander Fullerton, Susan M. Fleetwood-Walker, Yolanda S. Kap, Roderick N. Carter, Daniel M. Altmann, David A. Lyons, Markus Kipp, Sarah Al-Azki, Aniket Ghosh, Robin J.M. Franklin, Jan M. Schwab, Moses Rodriguez, Jordon Dunham, Stephanie E J Zandee, Nicholas M. Morton, Michele Zagnoni, Chao Zhao, Katie McGill, Bruce D. Trapp, Rory Mitchell

Publikováno v: Licht-Mayer, S, Campbell, G R, Canizares, M, Mehta, A R, Gane, A B, McGill, K, Ghosh, A, Fullerton, A, Menezes, N, Dean, J, Dunham, J, Al-Azki, S, Pryce, G, Zandee, S, Zhao, C, Kipp, M, Smith, K J, Baker, D, Altmann, D, Anderton, S M, Kap, Y S, Laman, J D, Hart, B A, Rodriguez, M, Watzlawick, R, Schwab, J M, Carter, R, Morton, N, Zagnoni, M, Franklin, R J M, Mitchell, R, Fleetwood-Walker, S, Lyons, D A, Chandran, S, Lassmann, H, Trapp, B D & Mahad, D J 2020, ' Enhanced axonal response of mitochondria to demyelination offers neuroprotection : Implications for multiple sclerosis ', Acta Neuropathologica, vol. 140, no. 2, pp. 143–167 . https://doi.org/10.1007/s00401-020-02179-x
Acta Neuropathologica
Acta Neuropathologica, 140(2), 143-167. SPRINGER

Axonal loss is the key pathological substrate of neurological disability in demyelinating disorders, including multiple sclerosis (MS). However, the consequences of demyelination on neuronal and axonal biology are poorly understood. The abundance of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e4693411de7b84ffffa08f0cedcee1
https://www.repository.cam.ac.uk/handle/1810/307933