Výsledky vyhledávání - "J. Z. Fields"

Implementation of the Fit Body and Soul, a Church-Based Life Style Program for Diabetes Prevention in High-Risk African Americans

Autor: S. Dodani, J. Z. Fields

Publikováno v: The Diabetes Educator. 36:465-472

Purpose The purpose of this study was to determine the effects of a behavioral faith-based diabetes prevention program called the Fit Body and Soul program in a semi-urban African-American church using a community-based participatory approach. Method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::557a0ec3695adab943918008ea822168
https://doi.org/10.1177/0145721710366756

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θ Isoform of Protein Kinase C Alters Barrier Function in Intestinal Epithelium through Modulation of Distinct Claudin Isotypes: A Novel Mechanism for Regulation of Permeability

Autor: A. Banan, L. J. Zhang, M. Shaikh, J. Z. Fields, S. Choudhary, C. B. Forsyth, A. Farhadi, A. Keshavarzian

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 313:962-982

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::598fd1a048769748438c1817473ffcd2
https://doi.org/10.1124/jpet.105.083428

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theta Isoform of protein kinase C alters barrier function in intestinal epithelium through modulation of distinct claudin isotypes: a novel mechanism for regulation of permeability

Autor: A, Banan, L J, Zhang, M, Shaikh, J Z, Fields, S, Choudhary, C B, Forsyth, A, Farhadi, A, Keshavarzian

Publikováno v: The Journal of pharmacology and experimental therapeutics. 313(3)

Using monolayers of intestinal Caco-2 cells, we discovered that the isoform of protein kinase C (PKC), a member of the "novel" subfamily of PKC isoforms, is required for monolayer barrier function. However, the mechanisms underlying this novel effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::be9b7e0920eca249c2f96cc9ab86f89b
https://pubmed.ncbi.nlm.nih.gov/15900076

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Evidence that nuclear factor-kappa B activation is critical in oxidant-induced disruption of the microtubule cytoskeleton and barrier integrity and that its inactivation is essential in epidermal growth factor-mediated protection of the monolayers of intestinal epithelia

Autor: A, Banan, A, Farhadi, J Z, Fields, E, Mutlu, L, Zhang, A, Keshavarzian

Publikováno v: The Journal of pharmacology and experimental therapeutics. 306(1)

Using monolayers of intestinal (Caco-2) cells, we showed that oxidants disrupt the microtubule cytoskeleton and barrier integrity; epidermal growth factor (EGF) was protective via stabilization of the microtubules. Because proinflammatory conditions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5179b826081cdedb62fd097f5b21b481
https://pubmed.ncbi.nlm.nih.gov/12815011

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Development of cross-resistance to tamoxifen in raloxifene-treated breast carcinoma cells

Autor: Z O, Gao, Z P, Gao, J Z, Fields, B M, Boman

Publikováno v: Anticancer research. 22(3)

Selective estrogen receptor modifiers (SERMs) are used chronically in the treatment of breast cancer and osteoporosis but some patients become resistant, at which point second-line SERMs are considered as options. Because the use of SERMs is increasi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e8acb9e030c37edb587b6459bf0382bf
https://pubmed.ncbi.nlm.nih.gov/12168814

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Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer

Autor: T, Zhang, T, Otevrel, Z, Gao, S M, Ehrlich, J Z, Fields, B M, Boman

Publikováno v: Cancer research. 61(24)

Because colorectal cancers (CRCs) frequently display APC mutation, inhibition of apoptosis, and increased expression of the antiapoptotic protein survivin, we hypothesized that APC mutation inhibits apoptosis by allowing constitutive survivin express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a785ee6418e97196a42fed6decd7c4aa
https://pubmed.ncbi.nlm.nih.gov/14744799

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Computer modeling implicates stem cell overproduction in colon cancer initiation

Autor: B M, Boman, J Z, Fields, O, Bonham-Carter, O A, Runquist

Publikováno v: Cancer research. 61(23)

On the basis of our investigation of the premalignant crypt phenotype in familial adenomatous polyposis patients, the hypothesis is developed that tumor initiation in the colon is caused by crypt stem cell overproduction. A novel kinetic model for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::79e07fe3f10fe8a0311344090e36e74e
https://pubmed.ncbi.nlm.nih.gov/11731419

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Preventing gut leakiness by oats supplementation ameliorates alcohol-induced liver damage in rats

Autor: A, Keshavarzian, S, Choudhary, E W, Holmes, S, Yong, A, Banan, S, Jakate, J Z, Fields

Publikováno v: The Journal of pharmacology and experimental therapeutics. 299(2)

Only 30% of alcoholics develop liver disease (ALD) suggesting that additional factors are needed. Endotoxin is one such factor, but its etiology is unclear. Since the gut is the main source of endotoxin, we sought to determine whether an increase in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5e201375592198bb5c8e9e4ff5d3e892
https://pubmed.ncbi.nlm.nih.gov/11602653

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Nitric oxide and its metabolites mediate ethanol-induced microtubule disruption and intestinal barrier dysfunction

Autor: A, Banan, J Z, Fields, H, Decker, Y, Zhang, A, Keshavarzian

Publikováno v: The Journal of pharmacology and experimental therapeutics. 294(3)

Loss of gastrointestinal (GI) barrier integrity has been implicated in a wide range of inflammatory illnesses, including alcoholic cirrhosis. Using monolayers of Caco-2 (intestinal) cells as a model, we showed that the ability of ethanol (EtOH) to di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fecd7c77f4ad00c06b565a4cd4226fa0
https://pubmed.ncbi.nlm.nih.gov/10945852

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Ethanol-induced barrier dysfunction and its prevention by growth factors in human intestinal monolayers: evidence for oxidative and cytoskeletal mechanisms

Autor: A, Banan, S, Choudhary, Y, Zhang, J Z, Fields, A, Keshavarzian

Publikováno v: The Journal of pharmacology and experimental therapeutics. 291(3)

Exposure of intestinal mucosa to ethanol (EtOH) disrupts barrier function and growth factors [epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha)] are protective, but the mechanisms remain obscure. Accordingly, we sought to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ed85f4f391dc8f9953c3cadb6c7536d6
https://pubmed.ncbi.nlm.nih.gov/10565827

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