Zobrazeno 1 - 10
of 121
pro vyhledávání: '"J. Wilmer"'
Autor:
Marit Keuper-Navis, Markus Walles, Birk Poller, Adam Myszczyszyn, Thomas K. van der Made, Joanne Donkers, Hossein Eslami Amirabadi, Martijn J. Wilmer, Saskia Aan, Bart Spee, Rosalinde Masereeuw, Evita van de Steeg
Publikováno v:
Pharmacological Research, Vol 195, Iss , Pp 106853- (2023)
Organ-on-chip (OoC) technology has led to in vitro models with many new possibilities compared to conventional in vitro and in vivo models. In this review, the potential of OoC models to improve the prediction of human oral bioavailability and intrin
Externí odkaz:
https://doaj.org/article/06d95e9d904945618f9e6018cbd79e94
Autor:
Manoe J. Janssen, Tom T.G. Nieskens, Tessa A.M. Steevels, Pedro Caetano-Pinto, Dirk den Braanker, Melissa Mulder, Yolanda Ponstein, Shaun Jones, Rosalinde Masereeuw, Cathaline den Besten, Martijn J. Wilmer
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 18, Iss , Pp 298-307 (2019)
Antisense oligonucleotide therapy has been reported to be associated with renal injury. Here, the mechanism of reversible proteinuria was investigated by combining clinical, pre-clinical, and in vitro data. Urine samples were obtained from Duchenne m
Externí odkaz:
https://doaj.org/article/b87e4abe3c8947bda573024c4f50791f
Autor:
Milos Mihajlovic, Lambertus P. van den Heuvel, Joost G. Hoenderop, Jitske Jansen, Martijn J. Wilmer, Annemarie J. F. Westheim, Wil A. Allebes, Dimitrios Stamatialis, Luuk B. Hilbrands, Rosalinde Masereeuw
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Novel renal replacement therapies, such as a bioartificial kidney (BAK), are needed to improve current hemodialysis treatment of end-stage renal disease (ESRD) patients. As BAK applications may reveal safety concerns, we assessed the alloimm
Externí odkaz:
https://doaj.org/article/108b767fdee94ce88e5583af35dafa74
Akademický článek
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Autor:
Joost P. Schoeber, Elena Levtchenko, Lambertus P. van den Heuvel, Dorien Reijnders, Martijn J. Wilmer, Karen Peeters, Rosalinde Masereeuw
Publikováno v:
Pharmaceutics, Vol 3, Iss 4, Pp 782-792 (2011)
P-glycoprotein (P-gp) is an ATP-dependent transporter localized at the apical membrane of the kidney proximal tubules, which plays a role in the efflux of cationic and amphipathic endogenous waste products and xenobiotics, such as drugs, into urine.
Externí odkaz:
https://doaj.org/article/88f1588550094a7782e6279e180e8963
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Autor:
Martijn J. Wilmer, Ernst Ahlberg, Mikael Persson, Simone H. Stahl, Anna-Karin Sjögren, Malin Forsgard, Jorrit J. Hornberg, Lucas Milton, Katarina Breitholtz
Publikováno v:
Archives of Toxicology, 92, 3175-3190
Archives of Toxicology, 92, 10, pp. 3175-3190
Archives of Toxicology, 92, 10, pp. 3175-3190
Contains fulltext : 196765.pdf (Publisher’s version ) (Closed access) Drug-induced nephrotoxicity is a major concern in the clinic and hampers the use of available treatments as well as the development of innovative medicines. It is typically disco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86edfea0e525dda11ec47e606d0d0513
https://doi.org/10.1007/s00204-018-2284-y
https://doi.org/10.1007/s00204-018-2284-y
Autor:
Frans G. M. Russel, Martijn J. Wilmer
Publikováno v:
Handbook of Biomarkers and Precision Medicine ISBN: 9780429202872
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9a66c8a6f1470a4615f338b49f2e44a
https://doi.org/10.1201/9780429202872-10
https://doi.org/10.1201/9780429202872-10
Autor:
Henriëtte L. Lanz, Paul Vulto, Martijn J. Wilmer, Chee Ping Ng, Rosalinde Masereeuw, Laura Suter-Dick
Publikováno v:
Trends in Biotechnology, 34, 156-70
Trends in Biotechnology, 34, 2, pp. 156-70
Trends in Biotechnology, 34, 2, pp. 156-70
Contains fulltext : 170854.pdf (Publisher’s version ) (Closed access) Improved model systems to predict drug efficacy, interactions, and drug-induced kidney injury (DIKI) are crucially needed in drug development. Organ-on-a-chip technology is a sui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64345fb124e83e1db0385becedee685
https://doi.org/10.1016/j.tibtech.2015.11.001
https://doi.org/10.1016/j.tibtech.2015.11.001
Autor:
Frans G. M. Russel, Alexander H. van Asbeck, Janny G. P. Peters, Neslihan N. Tavraz, Rosalinde Masereeuw, Thomas Friedrich, Tom T. G. Nieskens, Martijn J. Wilmer, Daphne Korte, Katja Jansen, Dina Dabaghie
Publikováno v:
Drug Metabolism and Disposition, 46, 592-599
Drug Metabolism and Disposition, 46, 5, pp. 592-599
Drug Metabolism and Disposition, 46, 5, pp. 592-599
Contains fulltext : 193213.pdf (Publisher’s version ) (Open Access) Cisplatin is a cytostatic drug used for treatment of solid organ tumors. The main adverse effect is organic cation transporter 2 (OCT2)-mediated nephrotoxicity, observed in 30% of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095afbd7d7437c076bc1c5acad7a4e00
http://hdl.handle.net/2066/193213
http://hdl.handle.net/2066/193213