Zobrazeno 1 - 10
of 290
pro vyhledávání: '"J. William Lown"'
Publikováno v:
The Scientific World Journal, Vol 2, Pp 155-168 (2002)
A new Maxxam All-Season Passive Sampling system for monitoring H2S in air has been developed. This passive sampling system employs the same approaches as the Maxxam All-Season Passive Sampling Systems for monitoring SO2, NO2, and O3 reported previous
Externí odkaz:
https://doaj.org/article/f7d0d70a0f3e4398b4d81e89c76cc63c
Publikováno v:
Letters in Organic Chemistry. 1:154-158
Publikováno v:
Journal of Drug Targeting. 12:125-134
RNAse mimics are small molecules that can cleave RNA in a fashion similar to ribonucleases. These compounds would be very useful as gene specific reagents if their activities could be regulated and targeted. We demonstrate here that polyamides with m
Synthesis and Antitumor Cytotoxicity Evaluation of Novel Thiazole-Containing Glycosylated Polyamides
Autor:
J. William Lown, Rohtash Kumar
Publikováno v:
European Journal of Organic Chemistry. 2003:4842-4851
Certain thiazole-containing water-soluble glycosylated polyamides were synthesized and preliminary anti-cancer evaluation carried out by NCI against three types of cancer-cells. Glycosyl moieties were introduced onto the polyamide backbone in order t
Publikováno v:
The Scientific World Journal, Vol 2, Pp 155-168 (2002)
The Scientific World Journal
The Scientific World Journal
A new Maxxam All-Season Passive Sampling system for monitoring H2S in air has been developed. This passive sampling system employs the same approaches as the Maxxam All-Season Passive Sampling Systems for monitoring SO2, NO2, and O3reported previousl
Publikováno v:
Molecular Medicine. 7:797-802
The biological activity of enediyne chemotherapeutic (anti-cancer) agents is attributed to their ability to cleave duplex DNA. Part of the reaction of cleavage is the abstraction of hydrogens from the deoxyribose moiety of DNA by the biradical formed
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:769-772
The design and synthesis of the lipophilic (9) and fluorescent (10) conjugates of a structural analogue of distamycin and their in vitro cellular localization studies are reported. Confocal laser scanning microscopy (CLSM) indicates that 10 rapidly e
Publikováno v:
Biochemical and Biophysical Research Communications. 281:1283-1290
Imidazole and compounds containing imidazole residues have been shown to cleave RNA in an RNase A-mimicking manner. Di-imidazole lexitropsin is a compound which is derived from the polyamide drugs distamycin and netropsin essentially by the replaceme
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 19:1365-1379
The binding of ligands to nucleic acids is of great interest for the control of gene expression and other nucleic acid mediated processes. We have evaluated the binding of several geometrically-constrained bis-distamycins to a model Okazaki fragment
Autor:
Guofeng Jia, J. William Lown
Publikováno v:
Bioorganic & Medicinal Chemistry. 8:1607-1617
Three types of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI) dimers were designed, synthesized and evaluated in vitro by NCI against nine types of cancer cells. Biological results showed that the antitumor activities of these seco-