Výsledky vyhledávání - "J. Will Reed"

Molecular Signaling Mechanisms of Natural and Synthetic Retinoids for Inhibition of Pathogenesis in Alzheimer’s Disease

Autor: Alexander J. McDonald, Bhaskar C. Das, Mrinmay Chakrabarti, Melissa A. Moss, J. Will Reed, Swapan K. Ray

Publikováno v: Journal of Alzheimer's Disease. 50:335-352

Retinoids, which are vitamin A derivatives, interact through retinoic acid receptors (RARs) and retinoid X receptors (RXRs) and have profound effects on several physiological and pathological processes in the brain. The presence of retinoic acid sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe560367b4e81bd08c4dec10ea47dde
https://doi.org/10.3233/jad-150450

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Activation of Brain Endothelium by Soluble Aggregates of the Amyloid-β Protein Involves Nuclear Factor-κB

Autor: Deborah D. Soto-Ortega, Francisco J. Gonzalez-Velasquez, J. Will Reed, Emily E. Matherly, John W. Fuseler, Melissa A. Moss, Joseph A. Kotarek

Publikováno v: Current Alzheimer Research. 8:81-94

Cerebrovascular accumulation of amyloid-β protein (Aβ) aggregates in Alzheimer's disease (AD) is proposed to contribute to disease progression and brain inflammation as a result of Aβ-induced increases in endothelial monolayer permeability and sti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54d8b05c2879a0a4d0691b95f9c1af19
https://doi.org/10.2174/156720511794604606

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Soluble Amyloid-β Protein Aggregates Induce Nuclear Factor-κB Mediated Upregulation of Adhesion Molecule Expression to Stimulate Brain Endothelium for Monocyte Adhesion

Autor: J. Will Reed, Francisco J. Gonzalez-Velasquez, Melissa A. Moss, Joseph A. Kotarek, John W. Fuseler, Deborah D. Soto-Ortega, Emily E. Matherly

Publikováno v: Journal of Adhesion Science and Technology. 24:2105-2126

The adhesion of circulating monocytes to cerebrovascular endothelium has the potential to contribute to the pathogenesis of Alzheimer's disease (AD). In AD, the amyloid-β protein (Aβ) assembles to form fibrils that deposit within both the brain par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::476421ee85d4afa7fd79307160af418a
https://doi.org/10.1163/016942410x507948

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