Výsledky vyhledávání - "J. Wikstrand"

Supplementary Methods from Construction of an Immunotoxin, D2C7-(scdsFv)-PE38KDEL, Targeting EGFRwt and EGFRvIII for Brain Tumor Therapy

Autor: Darell D. Bigner, Ira H. Pastan, Chien-Tsun Kuan, Roger E. McLendon, Carol J. Wikstrand, Hailan Piao, Scott E. Szafranski, Charles N. Pegram, Stephen T. Keir, Xuhui Bao, Vidyalakshmi Chandramohan

Supplementary Methods - PDF file 94K, The supplementary methods section describes the following: Construction, expression and purification of different EGFRvIII deletion mutants, cloning of variable heavy (VH) and variable light (VL) domains of P588

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9fc021499967905c42beb95c7bfd54
https://doi.org/10.1158/1078-0432.22447884.v1

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Data from Construction of an Immunotoxin, D2C7-(scdsFv)-PE38KDEL, Targeting EGFRwt and EGFRvIII for Brain Tumor Therapy

Purpose: The EGF receptor gene (EGFR) is most frequently amplified and overexpressed, along with its deletion mutant, EGFRvIII, in glioblastoma. We tested the preclinical efficacy of the recombinant immunotoxin, D2C7-(scdsFv)-PE38KDEL, which is react

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f430ba6f517228132aa45ef5e49135
https://doi.org/10.1158/1078-0432.c.6521244.v1

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Supplementary Figures 1-9 from Construction of an Immunotoxin, D2C7-(scdsFv)-PE38KDEL, Targeting EGFRwt and EGFRvIII for Brain Tumor Therapy

Supplementary Figures 1-9 - Supplementary Figures 1-9 - PDF file 516K, Supplementary Figure S1. Deduced amino acid sequence of the D2C7 scFv cloned from D2C7 hybridoma. VH (A) and VL (B) antigen-binding regions of the D2C7 scFv. Amino acid numbering

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3c8becb44d363b42717644935e5b6d
https://doi.org/10.1158/1078-0432.22447887

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Detection of Amino-terminal Extracellular Domain of Somatostatin Receptor 2 by Specific Monoclonal Antibodies and Quantification of Receptor Density in Medulloblastoma

Autor: Roger E. McLendon, Ujendra Kumar, Darell D. Bigner, Carol J. Wikstrand, Michael R. Zalutsky, Chien-Tsun Kuan

Publikováno v: Hybridoma. 28:389-403

Somatostatin receptor 2 (SSTR2) is expressed by most medulloblastomas (MEDs). We isolated monoclonal antibodies (MAbs) to the 12-mer (33)QTEPYYDLTSNA(44), which resides in the extracellular domain of the SSTR2 amino terminus, screened the peptide-bou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71588fff69d541dd8a747db7f09ddbfd
https://doi.org/10.1089/hyb.2009.0049

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Mutant Epidermal Growth Factor Receptor (EGFRvIII) Contributes to Head and Neck Cancer Growth and Resistance to EGFR Targeting

Autor: Jennifer R. Grandis, Francesca M. Coppelli, Sufi M. Thomas, John C. Sok, Darell D. Bigner, Miriam N. Lango, Carol J. Wikstrand, William E. Gooding, Sichuan Xi, Frank B. Furnari, Maria L. Freilino, Jennifer L. Hunt, Michael W. Graner

Publikováno v: Clinical Cancer Research. 12:5064-5073

Purpose: Epidermal growth factor receptor (EGFR) is overexpressed in head and neck squamous cell carcinoma (HNSCC) where expression levels correlate with decreased survival. Therapies that block EGFR have shown limited efficacy in clinical trials and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f945352f385d771b8ffa2e5534ba046d
https://doi.org/10.1158/1078-0432.ccr-06-0913

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Glycoprotein Nonmetastatic Melanoma Protein B, a Potential Molecular Therapeutic Target in Patients with Glioblastoma Multiforme

Autor: James E. Herndon, David A. Reardon, Darell D. Bigner, Gregory J. Riggins, Chien-Tsun Kuan, Michael W. Graner, Jeannette M. Dowell, Carol J. Wikstrand, Kenji Wakiya

Publikováno v: Clinical Cancer Research. 12:1970-1982

Purpose: More brain tumor markers are required for prognosis and targeted therapy. We have identified and validated promising molecular therapeutic glioblastoma multiforme (GBM) targets: human transmembrane glycoprotein nonmetastatic melanoma protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e13632f33f8fbcb48894a1647e284231
https://doi.org/10.1158/1078-0432.ccr-05-2797

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Development of a Syngeneic Rat Brain Tumor Model Expressing EGFRvIII and Its Use for Molecular Targeting Studies with Monoclonal Antibody L8A4

Autor: Weilian Yang, Rolf F. Barth, Gong Wu, Michael J. Ciesielski, Robert A. Fenstermaker, Bradford A. Moffat, Brian D. Ross, Carol J. Wikstrand

Publikováno v: Clinical Cancer Research. 11:341-350

Purpose: The goals of the present study were 2-fold: (a) to develop and characterize a rat brain tumor model that could be used for studies of molecular targeting of EGFRvIII and (b) to study the tumor localizing properties of radiolabeled monoclonal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7afcaad82eaae076f4255495271c58eb
https://doi.org/10.1158/1078-0432.341.11.1

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