Zobrazeno 1 - 10
of 803
pro vyhledávání: '"J. Whitworth"'
Publikováno v:
Smart Agricultural Technology, Vol 3, Iss , Pp 100101- (2023)
Potato virus Y (Potyviridae, PVY) is a plant virus that poses a significant threat to potato producers on a global basis. The pathogen has disrupted seed potato supplies and negatively impacted yield and quality of commercial potato crops. The potato
Externí odkaz:
https://doaj.org/article/07a22dceb72a4bcc901c43d8af5427d5
Publikováno v:
European Urology Open Science, Vol 19, Iss , Pp e2205- (2020)
Externí odkaz:
https://doaj.org/article/63493bd227574755b311a207a5d4456e
Autor:
Aitor Martinez, Alvaro Sanchez-Martinez, Jake T. Pickering, Madeleine J. Twyning, Ana Terriente-Felix, Po-Lin Chen, Chun-Hong Chen, Alexander J. Whitworth
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-21 (2024)
Abstract Background Mitochondrial dysfunction and toxic protein aggregates have been shown to be key features in the pathogenesis of neurodegenerative diseases, such as Parkinson’s disease (PD). Functional analysis of genes linked to PD have reveal
Externí odkaz:
https://doaj.org/article/2aa9e015c08a421a94ce4e2d5ab28568
Autor:
Arti A. Singh, Frances M. Shapter, Anne Bernard, Deanne J. Whitworth, Marnie G. Holt, Philip S. Waller, Stephanie L. Bond
Publikováno v:
Animals, Vol 14, Iss 16, p 2335 (2024)
No single teaching strategy supports all learning styles in veterinary science students. To facilitate more convenient and flexible teaching, learning, and revision, an innovative online digital learning platform—VetCloud—was developed to provide
Externí odkaz:
https://doaj.org/article/1f30de732b4742cfbc338e251b61df7f
Autor:
Madeleine J. Twyning, Roberta Tufi, Thomas P. Gleeson, Kinga M. Kolodziej, Susanna Campesan, Ana Terriente-Felix, Lewis Collins, Federica De Lazzari, Flaviano Giorgini, Alexander J. Whitworth
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113681- (2024)
Summary: Mitochondrial calcium (Ca2+) uptake augments metabolic processes and buffers cytosolic Ca2+ levels; however, excessive mitochondrial Ca2+ can cause cell death. Disrupted mitochondrial function and Ca2+ homeostasis are linked to numerous neur
Externí odkaz:
https://doaj.org/article/9603e362758f41768755e35b7a1109b6
Autor:
Xiaoyan Cheng, Xuming Liu, Katherine W. Jordan, Jingcheng Yu, Robert J. Whitworth, Yoonseong Park, Ming-Shun Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8296 (2024)
Glycoside hydrolases (GHs, also called glycosidases) catalyze the hydrolysis of glycosidic bonds in polysaccharides. Numerous GH genes have been identified from various organisms and are classified into 188 families, abbreviated GH1 to GH188. Enzymes
Externí odkaz:
https://doaj.org/article/155c9a3e8581412baa973ed88a22cf89
Publikováno v:
PLoS Biology, Vol 21, Iss 8, p e3002244 (2023)
Functional analyses of genes linked to heritable forms of Parkinson's disease (PD) have revealed fundamental insights into the biological processes underpinning pathogenic mechanisms. Mutations in PARK15/FBXO7 cause autosomal recessive PD and FBXO7 h
Externí odkaz:
https://doaj.org/article/e900e718fce2414b9f2634cbcbed0576
Autor:
Adeola O. Adedara, Ayoade D. Babalola, Flora Stephano, Ifeoluwa O. Awogbindin, James O. Olopade, João B. T. Rocha, Alexander J. Whitworth, Amos O. Abolaji
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Loss-of-function mutations in parkin is associated with onset of juvenile Parkinson’s disease (PD). Resveratrol is a polyphenolic stilbene with neuroprotective activity. Here, we evaluated the rescue action of resveratrol in parkin mutant
Externí odkaz:
https://doaj.org/article/6205024f615442578ea848ff5afc1b91
Autor:
Temitope C. Akinade, Oreoluwa O. Babatunde, Adeola O. Adedara, Olugbenga E. Adeyemi, Titilayomi A. Otenaike, Onaara P. Ashaolu, Titilayo O. Johnson, Ana Terriente-Felix, Alexander J. Whitworth, Amos O. Abolaji
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Trans-astaxanthin (TA), a keto-carotenoid found in aquatic invertebrates, possesses anti-oxidative and anti-inflammatory activities. Rotenone is used to induce oxidative stress-mediated Parkinson’s disease (PD) in animals. We probed if TA
Externí odkaz:
https://doaj.org/article/a17d0d79581c435bbb38d3097f3cc4d9
Autor:
Pedro Rebelo-Guiomar, Simone Pellegrino, Kyle C. Dent, Aldema Sas-Chen, Leonor Miller-Fleming, Caterina Garone, Lindsey Van Haute, Jack F. Rogan, Adam Dinan, Andrew E. Firth, Byron Andrews, Alexander J. Whitworth, Schraga Schwartz, Alan J. Warren, Michal Minczuk
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Rebelo-Guiomar et al. unveil late stage assembly intermediates of the human mitochondrial ribosome by inactivating the methyltransferase MRM2 in cells. Absence of MRM2 impairs organismal homeostasis, while its catalytic activity is dispensable for mi
Externí odkaz:
https://doaj.org/article/b26a6648dba14e5181a35583967acaa7