Zobrazeno 1 - 10
of 349
pro vyhledávání: '"J. Wepierre"'
Publikováno v:
Toxicology in Vitro. 11:645-651
A three-dimensional culture of human keratinocytes exposed at the air-liquid interface has been developed and used in conjunction with fluorimetric, colorimetric and radioligand incorporation assays to assess the in vitro toxicity of UVA. The aims of
Publikováno v:
International Journal of Pharmaceutics. 126:235-243
The percutaneous absorption and the cutaneous distribution of a new antiandrogen, RU 58841, 0.5% in liposomes or in solution were compared after topical application. In vitro percutaneous absorption experiments were performed on human dermatomed skin
Autor:
Jean-Daniel Marty, J. Doucet, Jean-Louis Grossiord, J. Wepierre, Lucas Antônio Miranda Ferreira, M. Seiller
Publikováno v:
International Journal of Pharmaceutics. 121:169-179
The percutaneous absorption of model hydrophilic drugs with intermediate and high polarity, metronidazole and glucose, respectively, from three emulsion types (o/w, w/o/w and w/o) has been studied. All the emulsions were prepared with exactly the sam
Publikováno v:
Journal of Controlled Release. 33:349-356
The in vitro release and percutaneous absorption of glucose as a hydrophilic model drug from oil/water (o/w), water/oil/ water (w/o/w) and water/oil (w/o) emulsions has been studied. All the emulsions were prepared with exactly the same composition i
Publikováno v:
Cell Biology and Toxicology. 10:361-365
Culture of keratinocytes on a noncoated porous synthetic membrane maintained at the air-liquid interface allows the establishment of a fibroblast/keratinocyte co-culture, without direct cell-cell contant between the two cellular layers. The influence
Autor:
J. Wepierre, Lucas Antônio Miranda Ferreira, M. Seiller, Jean-Daniel Marty, Jean-Louis Grossiord
Publikováno v:
International Journal of Pharmaceutics. 109:251-259
Few studies have been made on the topical administration of w/o/w multiple emulsions, although their advantages in the controlled release by oral and parenteral administration have already been shown. The objective of this study was to compare the in
Publikováno v:
Toxicology in Vitro. 8:235-242
Two in vitro methods to investigate free radical damage to cultured human skin fibroblasts have been used: irradiation with UVA or UVB, producing intracellular free radicals and DNA damage, or free radical production by the enzymatic system hypoxanth
Autor:
F. L. Bamba, J. Wepierre
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 18:339-348
We studied the percutaneous absorption of [14C]-labelled pyridostigmine bromide mixed into various vehicles through normal and appendage-free scar rat skin, in vitro during 72 h. At the end of the experiment, the percentages of the drug absorbed were
Publikováno v:
Toxicology in Vitro. 6:423-432
The sensitive single-cell analytical techniques of flow cytometry and propidium iodide-binding have been used to examine the molecular effect of oxidative stress on cultured human skin fibroblasts. Cells synchronized by limited time attachment were e
Publikováno v:
Toxicology in Vitro. 6:119-128
The cytotoxicity of surfactants was evaluated on cultures of human skin fibroblasts and keratinocytes in order to predict their eye irritancy potential taking into account both immediate cytotoxicity after 2 hr of incubation and delayed cytotoxicity