Výsledky vyhledávání - "J. Wayne Cowens"

Factors Predicting Late Recurrence for Estrogen Receptor–Positive Breast Cancer

Autor: Sean Ferree, Ivana Sestak, Mitch Dowsett, Elena Lopez-Knowles, Jack Cuzick, J. Wayne Cowens, Lila Zabaglo

Publikováno v: JNCI Journal of the National Cancer Institute

Adjuvant chemotherapy and endocrine therapy for early breast cancer have had a considerable impact on outcomes (1), but a substantial number of women, especially those with estrogen receptor (ER)–positive tumors, remain at risk for late recurrences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6779f8bbef3340d0c6615832c28bb251
https://doi.org/10.1093/jnci/djt244

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Comparison of PAM50 Risk of Recurrence Score With Oncotype DX and IHC4 for Predicting Risk of Distant Recurrence After Endocrine Therapy

Autor: Ivana Sestak, Jack Cuzick, Sean Ferree, James Storhoff, Anita K. Dunbier, Elena Lopez-Knowles, Kalvinder Sidhu, Mitch Dowsett, Carl Schaper, J. Wayne Cowens

Publikováno v: Journal of Clinical Oncology. 31:2783-2790

Purpose Risk of distant recurrence (DR) among women with estrogen receptor (ER) –positive early breast cancer is the major determinant of recommendations for or against chemotherapy. It is frequently estimated using the Oncotype DX recurrence score

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5203d358592e2cdad27a05224afe18
https://doi.org/10.1200/jco.2012.46.1558

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Relationship between tumor gene expression and recurrence in four independent studies of patients with stage II/III colon cancer treated with surgery alone or surgery plus adjuvant fluorouracil plus leucovorin

Autor: Joffre B. Baker, Ian C. Lavery, Norman Wolmark, Margarita Lopatin, Frederick L. Baehner, Drew Watson, Soonmyung Paik, Kim M. Clark-Langone, Michael O’Connell, J. Wayne Cowens, Greg Yothers, Steven Shak

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 28(25)

Purpose These studies were conducted to determine the relationship between quantitative tumor gene expression and risk of cancer recurrence in patients with stage II or III colon cancer treated with surgery alone or surgery plus fluorouracil (FU) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504e8a67eff77b5bbff771dfae7ef9bf
https://pubmed.ncbi.nlm.nih.gov/20679612

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New site-directed polyclonal antibody maps N-terminus of occluded region of the non-transformed glucocorticoid receptor oligomer to within bugr epitope

Autor: M Ip Margot, Wendy K. Shea, J. Wayne Cowens

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 39:433-447

Using a 17-mer synthetic peptide for immunization, a polyclonal antibody (WS933) directed against amino acid residues 395–411 of the mouse glucocorticoid receptor (GCR) has been raised and used to probe the significance of this region in forming th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a2921785b47ee7c137c0f8643313b2
https://doi.org/10.1016/0960-0760(91)90236-x

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An Application of a Statistical Approach to the Calibration and Validation of Analytical Assays for Investigations Drugs: Quantitation of CGP19984D, A Thiazolidinedione Derivative with Antitumor Activity, and its Two Diastereomers in Biological Fluids by High Performance Liquid Chromatography

Autor: William R. Greco, J. Wayne Cowens, Gabor Papp, John C. Parsons

Publikováno v: Journal of Liquid Chromatography. 13:887-911

A set of statistical procedures has been developed for: 1) the construction of linear standard curves for cases in which the sensitivity of the assay spans a 1000-fold range; 2) the estimation of unknown compound concentrations with associated fiduci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01799ca7bca4057f534fc2964d66f761
https://doi.org/10.1080/01483919008049220

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Clinical Studies with Liposomal Doxorubicin

Autor: George Browman, Ostro Marc J, Richard S. Ginsberg, Patrick J. Creaven, J. Wayne Cowens

Publikováno v: Journal of Liposome Research. 1:481-490

To present data on a continuing phase I study of liposomal doxorubicin at this time may seem like a giant leap backwards. Liposomally encapsulated doxorubicin has been available for clinical use for some years. Phase I studies have been completed, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b5f39a7f109a2392f5c1762d2b270b9
https://doi.org/10.3109/08982109009036009

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A phase I clinical trial of a ribozyme-based angiogenesis inhibitor targeting vascular endothelial growth factor receptor-1 for patients with refractory solid tumors

Autor: David E. Weng, Nassim Usman, T. Elise Jackson, J. Wayne Cowens, Paul Elson, Patricia A. Weiss, Ram Ganapathi, Vann P. Parker, Ernest C. Borden, Susan F. Radka, Paul Masci, Jennifer A. Lockridge, William B. Capra

Publikováno v: Molecular cancer therapeutics. 4(6)

Purpose: This study intended to determine the maximum tolerated dose, safety, pharmacokinetic variables, clinical response, and pharmacodynamic markers of daily s.c. administration of Angiozyme. Patients and Methods: Patients with refractory solid tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9932829804380e59b82ace2c944e146b
https://pubmed.ncbi.nlm.nih.gov/15956252

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Multicenter evaluation of a human monoclonal antibody to Enterobacteriaceae common antigen in patients with Gram-negative sepsis

Autor: J. Wayne Cowens, Timothy E Albertson, Ernest Benjamin, Jeffrey Tobias, Steven B. Johnson, George M. Matuschak, Gary P. Zaloga, Edward A. Panacek, Jeffrey H. Silverstein, Kathy Haenftling, Dennis G. Maki, Rodger D. MacArthur, George E. Black

Publikováno v: Critical care medicine. 31(2)

Objective: To evaluate in Gram-negative sepsis patients the human monoclonal immunoglobulin M antibody (MAB-T88) directed at the enterobacterial common antigen which is a specific surface antigen closely linked to lipopolysaccharide and shared by all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88c50d4102bde8ef74816c97663046f
https://pubmed.ncbi.nlm.nih.gov/14758202

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