Zobrazeno 1 - 10
of 71
pro vyhledávání: '"J. Wayne Conlan"'
Autor:
Roberto De Pascalis, Blake Frey, Helen M. Rice, Varunika Bhargava, Terry H. Wu, Ross L. Peterson, J. Wayne Conlan, Anders Sjöstedt, Karen L. Elkins
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-14 (2022)
Abstract Francisella tularensis, the causative agent of tularemia, is classified as Tier 1 Select Agent with bioterrorism potential. The efficacy of the only available vaccine, LVS, is uncertain and it is not licensed in the U.S. Previously, by using
Externí odkaz:
https://doaj.org/article/45867fd5b2b64f7ea1f1656039948dd5
Autor:
J. Wayne Conlan, Anders Sjöstedt, H. Carl Gelhaus, Perry Fleming, Kevan McRae, Ronald R. Cobb, Roberto De Pascalis, Karen L. Elkins
Publikováno v:
Pathogens, Vol 10, Iss 7, p 795 (2021)
Inhalation of small numbers of Francisella tularensis subspecies tularensis (Ftt) in the form of small particle aerosols causes severe morbidity and mortality in people and many animal species. For this reason, Ftt was developed into a bona fide biol
Externí odkaz:
https://doaj.org/article/fc3bce072b1c44ab94a56b3f63811d93
Publikováno v:
Pathogens, Vol 1, Iss 1, Pp 12-29 (2012)
Using a strategy of gene deletion mutagenesis, we have examined the roles of genes putatively involved in lipopolysaccharide biosynthesis in the virulent facultative intracellular bacterial pathogen, Francisella tularensis subspecies tularensis, stra
Externí odkaz:
https://doaj.org/article/be5c95add43b4061a716278a7c0f70f8
Publikováno v:
Mediators of Inflammation, Vol 2008 (2008)
This study examined the role of lymphotoxin (LT)-α in host defense against airborne infection with Francisella tularensis, a gram-negative facultative intracellular bacterium and the causative agent of tularemia. Following a low-dose aerosol infecti
Externí odkaz:
https://doaj.org/article/3b4677b18206434ea995ff59bdfd6e5a
Autor:
Roberto De Pascalis, Kevan Mcrae, H Carl Gelhaus, Ronald R Cobb, Perry Fleming, Anders Sjöstedt, J. Wayne Conlan, Karen L. Elkins
Publikováno v:
Pathogens
Volume 10
Issue 7
Pathogens, Vol 10, Iss 795, p 795 (2021)
Volume 10
Issue 7
Pathogens, Vol 10, Iss 795, p 795 (2021)
Inhalation of small numbers of Francisella tularensis subspecies tularensis (Ftt) in the form of small particle aerosols causes severe morbidity and mortality in people and many animal species. For this reason, Ftt was developed into a bona fide biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c830de1fe622f83788595eed06278c
https://nrc-publications.canada.ca/eng/view/object/?id=366ee55b-0949-4f5b-b2aa-c18cab1878e5
https://nrc-publications.canada.ca/eng/view/object/?id=366ee55b-0949-4f5b-b2aa-c18cab1878e5
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10000 (2010)
BackgroundFrancisella tularensis subspecies tularensis is the causative agent of a spectrum of diseases collectively known as tularemia. An attenuated live vaccine strain (LVS) has been shown to be efficacious in humans, but safety concerns have prev
Externí odkaz:
https://doaj.org/article/033943569f9446d397fdd2b51d229c17
Autor:
James C. Richards, Kelly M. Fulton, Susan M. Twine, John S. Spika, Marc Ouellette, Jennifer F Raven, J. Wayne Conlan, Luis Barreto, Lakshmi Krishnan
Publikováno v:
Human Vaccines & Immunotherapeutics. 11:2923-2930
Vaccine biomarkers are critical to many aspects of vaccine development and licensure, including bridging findings in pre-clinical studies to clinical studies, predicting potential adverse events, and predicting vaccine efficacy. Despite advances in o
Publikováno v:
Microbes and Infection. 13:447-456
Francisella tularensis subspecies (subsp.) tularensis is a CDC Category A biological warfare agent and inhalation of as few as 15 bacilli can initiate severe disease. Relatively little is known about the cellular and molecular mechanisms of host defe
Autor:
Gregory Harris, Mark Bolanowski, Wangxue Chen, J. Wayne Conlan, Anders Sjöstedt, Cecilia Rietz, Hua Shen, Xigeng Zhao
Publikováno v:
Molecular Immunology. 45:2962-2969
The type A subspecies of Francisella tularensis is a highly virulent facultative intracellular bacterial pathogen, and a potential biological weapon. Recently, there has been renewed interest in developing new vaccines and therapeutics against this b
Autor:
Anders Sjöstedt, Hua Shen, Susan M. Twine, Nadia C. S. Mykytczuk, John F. Kelly, J. Wayne Conlan, Mireille D. Petit
Publikováno v:
Biochemical and Biophysical Research Communications. 345:1621-1633
Understanding the pathogenesis of infectious diseases requires comprehensive knowledge of the proteins expressed by the pathogen during in vivo growth in the host. Proteomics provides the tools for such analyses but the protocols required to purify s