Zobrazeno 1 - 10
of 1 986
pro vyhledávání: '"J. Wakefield"'
Autor:
Ksenija Nesic, John J. Krais, Yifan Wang, Cassandra J. Vandenberg, Pooja Patel, Kathy Q. Cai, Tanya Kwan, Elizabeth Lieschke, Gwo-Yaw Ho, Holly E. Barker, Justin Bedo, Silvia Casadei, Andrew Farrell, Marc Radke, Kristy Shield-Artin, Jocelyn S. Penington, Franziska Geissler, Elizabeth Kyran, Robert Betsch, Lijun Xu, Fan Zhang, Alexander Dobrovic, Inger Olesen, Rebecca Kristeleit, Amit Oza, Iain McNeish, Gayanie Ratnayake, Nadia Traficante, Australian Ovarian Cancer Study, Anna DeFazio, David D. L. Bowtell, Thomas C. Harding, Kevin Lin, Elizabeth M. Swisher, Olga Kondrashova, Clare L. Scott, Neil Johnson, Matthew J. Wakefield
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-10 (2024)
Abstract PARP inhibitor (PARPi) therapy has transformed outcomes for patients with homologous recombination DNA repair (HRR) deficient ovarian cancers, for example those with BRCA1 or BRCA2 gene defects. Unfortunately, PARPi resistance is common. Mul
Externí odkaz:
https://doaj.org/article/8f0a9b712db94dd79db01d43d570add9
Autor:
Haineng Xu, Sarah B. Gitto, Gwo-Yaw Ho, Sergey Medvedev, Kristy Shield-Artin, Hyoung Kim, Sally Beard, Yasuto Kinose, Xiaolei Wang, Holly E. Barker, Gayanie Ratnayake, Wei-Ting Hwang, Ryan J. Hansen, Bryan Strouse, Snezana Milutinovic, Christian Hassig, Matthew J. Wakefield, Cassandra J. Vandenberg, Clare L. Scott, Fiona Simpkins
Publikováno v:
iScience, Vol 27, Iss 7, Pp 109978- (2024)
Summary: High-grade serous ovarian cancers (HGSOCs) with homologous recombination deficiency (HRD) are initially responsive to poly (ADP-ribose) polymerase inhibitors (PARPi), but resistance ultimately emerges. HGSOC with CCNE1 amplification (CCNE1am
Externí odkaz:
https://doaj.org/article/1ed5cdda17844d2e8fc282a3b801056b
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The RNase III enzyme Drosha has a central role in microRNA (miRNA) biogenesis, where it is required to release the stem-loop intermediate from primary (pri)-miRNA transcripts. However, it can also cleave stem-loops embedded within messenger
Externí odkaz:
https://doaj.org/article/ea631e45f46e47dbbc7707150c0a519c
Autor:
Richard J Wakefield, Paul Emery, Helena Marzo-Ortega, Dennis G McGonagle, Ai Lyn Tan, Andrea Di Matteo, Philip Helliwell, Gabriele De Marco, Or Hen, Sayam R Dubash
Publikováno v:
RMD Open, Vol 10, Iss 2 (2024)
Aims To investigate the prevalence and distribution of bone erosions in an early psoriatic arthritis (PsA) population using conventional radiography (CR) and to explore the agreement between CR and ultrasound (US) detected bone erosions.Methods Newly
Externí odkaz:
https://doaj.org/article/15f487623a5440dbaab3cb86594c7238
Autor:
Franziska Geissler, Ksenija Nesic, Olga Kondrashova, Alexander Dobrovic, Elizabeth M. Swisher, Clare L. Scott, Matthew J. Wakefield
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 16 (2024)
Epigenetic alterations, including aberrant DNA methylation, are now recognized as bone fide hallmarks of cancer, which can contribute to cancer initiation, progression, therapy responses and therapy resistance. Methylation of gene promoters can have
Externí odkaz:
https://doaj.org/article/149fbe6f4eb449958647e023e6a32ed0
Autor:
Genevieve Dall, Cassandra J. Vandenberg, Ksenija Nesic, Gayanie Ratnayake, Wenying Zhu, Joseph H. A. Vissers, Justin Bedő, Jocelyn Penington, Matthew J. Wakefield, Damien Kee, Amandine Carmagnac, Ratana Lim, Kristy Shield-Artin, Briony Milesi, Amanda Lobley, Elizabeth L. Kyran, Emily O’Grady, Joshua Tram, Warren Zhou, Devindee Nugawela, Kym Pham Stewart, Reece Caldwell, Lia Papadopoulos, Ashley P. Ng, Alexander Dobrovic, Stephen B. Fox, Orla McNally, Jeremy D. Power, Tarek Meniawy, Teng Han Tan, Ian M. Collins, Oliver Klein, Stephen Barnett, Inger Olesen, Anne Hamilton, Oliver Hofmann, Sean Grimmond, Anthony T. Papenfuss, Clare L. Scott, Holly E. Barker
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-20 (2023)
Abstract Background Uterine leiomyosarcoma (uLMS) is a rare and aggressive gynaecological malignancy, with individuals with advanced uLMS having a five-year survival of 0.2) but only two samples had a CHORD score > 50%, one of which had a homozygous
Externí odkaz:
https://doaj.org/article/90697e9e0fe04ca583a35a4167337ba8
Autor:
Gwo Yaw Ho, Cassandra J. Vandenberg, Ratana Lim, Elizabeth L. Christie, Dale W. Garsed, Elizabeth Lieschke, Ksenija Nesic, Olga Kondrashova, Gayanie Ratnayake, Marc Radke, Jocelyn S. Penington, Amandine Carmagnac, Valerie Heong, Elizabeth L. Kyran, Fan Zhang, Nadia Traficante, Ruby Huang, Alexander Dobrovic, Elizabeth M. Swisher, Orla McNally, Damien Kee, Matthew J. Wakefield, Anthony T. Papenfuss, David D. L. Bowtell, Holly E. Barker, Clare L. Scott
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 15 (2023)
Background: Despite initial response to platinum-based chemotherapy and PARP inhibitor therapy (PARPi), nearly all recurrent high-grade serous ovarian cancer (HGSC) will acquire lethal drug resistance; indeed, ~15% of individuals have de novo platinu
Externí odkaz:
https://doaj.org/article/acfd52763fdb4a6092abd9806478e071
Autor:
Richard A. Hoppmann, Jeanette Mladenovic, Lawrence Melniker, Radu Badea, Michael Blaivas, Miguel Montorfano, Alfred Abuhamad, Vicki Noble, Arif Hussain, Gregor Prosen, Tomás Villen, Gabriele Via, Ramon Nogue, Craig Goodmurphy, Marcus Bastos, G. Stephen Nace, Giovanni Volpicelli, Richard J. Wakefield, Steve Wilson, Anjali Bhagra, Jongyeol Kim, David Bahner, Chris Fox, Ruth Riley, Peter Steinmetz, Bret P. Nelson, John Pellerito, Levon N. Nazarian, L. Britt Wilson, Irene W. Y. Ma, David Amponsah, Keith R. Barron, Renee K. Dversdal, Mike Wagner, Anthony J. Dean, David Tierney, James W. Tsung, Paula Nocera, José Pazeli, Rachel Liu, Susanna Price, Luca Neri, Barbara Piccirillo, Adi Osman, Vaughan Lee, Nitha Naqvi, Tomislav Petrovic, Paul Bornemann, Maxime Valois, Jean-Francoise Lanctot, Robert Haddad, Deepak Govil, Laura A. Hurtado, Vi Am Dinh, Robert M. DePhilip, Beatrice Hoffmann, Resa E. Lewiss, Nayana A. Parange, Akira Nishisaki, Stephanie J. Doniger, Paul Dallas, Kevin Bergman, J. Oscar Barahona, Ximena Wortsman, R. Stephen Smith, Craig A. Sisson, James Palma, Mike Mallin, Liju Ahmed, Hassan Mustafa
Publikováno v:
The Ultrasound Journal, Vol 14, Iss 1, Pp 1-32 (2022)
Abstract Objectives The purpose of this study is to provide expert consensus recommendations to establish a global ultrasound curriculum for undergraduate medical students. Methods 64 multi-disciplinary ultrasound experts from 16 countries, 50 multi-
Externí odkaz:
https://doaj.org/article/299105751ec3469db3f71be3473a7b37
Publikováno v:
Annals of Cardiac Anaesthesia, Vol 25, Iss 4, Pp 505-513 (2022)
Context: Global longitudinal strain (GLS) measured by speckle-tracking echocardiography demonstrates excellent prognostic ability in predicting major adverse cardiac events after cardiac surgery. However, the optimal timing of intraoperative GLS meas
Externí odkaz:
https://doaj.org/article/e4e226b212434f2295c6072855bbe5a3
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 15 (2023)
Poly (ADP-ribose) polymerase inhibitors (PARPis) represent a therapeutic milestone in the management of epithelial ovarian cancer. The concept of ‘synthetic lethality’ is exploited by PARPi in tumors with defects in DNA repair pathways, particula
Externí odkaz:
https://doaj.org/article/8647ec783b77428fa1c329a92662d500