Výsledky vyhledávání - "J. W. Yewdell"

Generation and Protective Ability of Influenza Virus-Specific Antibody-Dependent Cellular Cytotoxicity in Humans Elicited by Vaccination, Natural Infection, and Experimental Challenge

Autor: Kanta Subbarao, Sinthujan Jegaskanda, Mark Y. Sangster, Carrie M. Rosenberger, J W Yewdell, Heather D. Hickman, Jacqueline McBride, John J. Treanor, Catherine J. Luke, Peter F. Wright, Wendy Wieland-Alter

Publikováno v: The Journal of infectious diseases. 214(6)

Background. Nonneutralizing antibodies (Abs) involved in antibody-dependent cellular cytotoxicity (ADCC) may provide some protection from influenza virus infection. The ability of influenza vaccines to induce ADCC-mediating Abs (ADCC-Abs) in adults a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f01a00342b995f7f15146e6ae84626
https://pubmed.ncbi.nlm.nih.gov/27354365

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The generation of MHC class I-associated peptides is only partially inhibited by proteasome inhibitors: involvement of nonproteasomal cytosolic proteases in antigen processing?

Autor: A Vinitsky, L C Antón, H L Snyder, M Orlowski, J R Bennink, J W Yewdell

Publikováno v: The Journal of Immunology. 159:554-564

The proteasome is believed to participate in the generation of a large percentage of peptide ligands for MHC class I molecules. This conclusion is based largely on the activities of peptidyl aldehydes that block proteasome activity. We tested the abi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d790abb7607815d9a10fe6cb4919720
https://doi.org/10.4049/jimmunol.159.2.554

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MHC class I-associated peptides produced from endogenous gene products with vastly different efficiencies

Autor: L C Anton, J W Yewdell, J R Bennink

Publikováno v: The Journal of Immunology. 158:2535-2542

We compared the efficiency of generating antigenic peptides from various polypeptide contexts expressed by recombinant vaccinia viruses. These included full-length influenza virus nucleoprotein (NP(1-498)), two truncated forms, and cytosolic and endo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e9eb1d3ec84131cb5741f3fa92b4314
https://doi.org/10.4049/jimmunol.158.6.2535

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MHC affinity, peptide liberation, T cell repertoire, and immunodominance all contribute to the paucity of MHC class I-restricted peptides recognized by antiviral CTL

Autor: Y Deng, J W Yewdell, L C Eisenlohr, J R Bennink

Publikováno v: The Journal of Immunology. 158:1507-1515

MHC class I-restricted T cell responses to viral proteins focus on a limited set of peptides. To better understand this phenomenon, we examined all of the 26 nonameric peptides encoded by the influenza virus A/Puerto Rico/8/34 (PR8) conforming to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::944089812a9dc6bc19aa155d3b9e123d
https://doi.org/10.4049/jimmunol.158.4.1507

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Structure of the N-linked oligosaccharides of MHC class I molecules from cells deficient in the antigenic peptide transporter. Implications for the site of peptide association

Autor: B K Hayes, F Esquivel, J R Bennink, J W Yewdell, A Varki

Publikováno v: The Journal of Immunology. 155:3780-3787

Class I molecules are N-linked glycoproteins encoded by the MHC. They carry cytosolic protein-derived peptides to the cell surface, displaying them to enable immune surveillance of cellular processes. Peptides are delivered to class I molecules by th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4156ab8f3bc64ee74823e5c0a5afb1db
https://doi.org/10.4049/jimmunol.155.8.3780

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Fluorescent conjugates of brefeldin A selectively stain the endoplasmic reticulum and Golgi complex of living cells

Autor: Hee Chol Kang, Yupind Deng, R. P. Haugland, J. R. Bennink, J. W. Yewdell

Publikováno v: Journal of Histochemistry & Cytochemistry. 43:907-915

The fungal metabolite brefeldin A (BFA) interferes with vesicular trafficking in most animal cells. To gain insight into the mechanism of BFA action, we esterified it to the fluorophore, boron dipyromethene difluoride (BODIPY). BODIPY-BEA localized p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f205d5df771f3a79ad1842e37eba6c
https://doi.org/10.1177/43.9.7543914

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Cytotoxic T cells specific for a single peptide on the M2 protein of respiratory syncytial virus are the sole mediators of resistance induced by immunization with M2 encoded by a recombinant vaccinia virus

Autor: Jack R. Bennink, Igor Bacik, Peter L. Collins, J W Yewdell, Brian R. Murphy, James E. Crowe, A B Kulkarni

Publikováno v: Scopus-Elsevier

We have studied the immunobiology of respiratory syncytial virus (RSV), a major cause of respiratory tract morbidity in children. As part of these studies, it was previously found that immunization of BALB/c (H-2d) mice with a recombinant vaccinia vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72aac6b0ae3cb7255b2915ad6e5a3b9
https://doi.org/10.1128/jvi.69.2.1261-1264.1995

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Presentation of endogenous and exogenous antigens is not affected by inactivation of E1 ubiquitin-activating enzyme in temperature-sensitive cell lines

Autor: J H Cox, P Galardy, J R Bennink, J W Yewdell

Publikováno v: The Journal of Immunology. 154:511-519

Little is known regarding the mechanism by which MHC class I-associated peptides are generated. Proteins can be targeted for degradation by the covalent attachment of ubiquitin. The first step in ubiquitin conjugation to proteins is its binding to E1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48d3050245badfe2969e79be88c6b527
https://doi.org/10.4049/jimmunol.154.2.511

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