Výsledky vyhledávání - "J. W. Vaupel"

[The remarkable rise in life expectancy and how it will affect medicine]

Publikováno v: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz. 48(5)

Life expectancy has increased at a steady pace in industrialized countries over the last 160 years. A slowdown is not evident: Since 1950 the number of people celebrating their 100th birthdays has at least doubled each decade. This increase in surviv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f3f407fd08b66ccd0c88606ed89ccfe7
https://pubmed.ncbi.nlm.nih.gov/15887070

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Haplotype effects on human survival: logistic regression models applied to unphased genotype data

Autor: Q, Tan, L, Christiansen, L, Bathum, J H, Zhao, W, Vach, J W, Vaupel, K, Christensen, T A, Kruse

Publikováno v: Annals of human genetics. 69(Pt 2)

Haplotype based linkage disequilibrium (LD) mapping exhibits higher power than the single locus approach because it makes use of the LD information contained in the flanking markers. New statistical methods have been proposed to help to infer haploty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::572a970264d05db2d70eb11d6f911f26
https://pubmed.ncbi.nlm.nih.gov/15720298

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Age validation of Han Chinese centenarians

Autor: Z, Wang, Y, Zeng, B, Jeune, J W, Vaupel

Publikováno v: Genus. 54(1-2)

"Based on a set of solid measures computed from the 1990 census data and the age validation procedures conducted in our Hangzhou, Beijing and Chengdu surveys, this paper shows that the Han Chinese centenarians' age reporting [is generally] good, beca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2824f3fe48e6bd50872c0ae42887911f
https://pubmed.ncbi.nlm.nih.gov/12321975

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The influences on human longevity by HUMTHO1.STR polymorphism (Tyrosine Hydroxylase gene). A relative risk approach

Autor: Qihua, Tan, D, Bellizzi, G, Rose, S, Garasto, C, Franceschi, T, Kruse, J W, Vaupel, G, De Benedictis, A I, Yashin

Publikováno v: Mechanisms of ageing and development. 123(10)

A new method based on the recently developed relative risk approach is introduced, and applied to data from Italian centenarian study (965 subjects aged from 13 to 109 years old) for investigating influences on longevity by Tyrosine Hydroxylase (TH)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f7ff27407f82c1ec3418b3fc30c07aab
https://pubmed.ncbi.nlm.nih.gov/12297342

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A logistic regression model for measuring gene-longevity associations

Autor: Q, Tan, A I, Yashin, G, De Benedictis, F, Cintolesi, G, Rose, M, Bonafe, C, Franceschi, W, Vach, J W, Vaupel

Publikováno v: Clinical genetics. 60(6)

The logistic regression model is a popular model for data analysis in epidemiological research. In this paper, we use this model to analyze genetic data collected from gene-longevity association studies. This new approach models the probability of ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::21a5bed2b88f7bf22727b94ef01e51e3
https://pubmed.ncbi.nlm.nih.gov/11846740

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The X chromosome and the female survival advantage: an example of the intersection between genetics, epidemiology and demography

Autor: K, Christensen, K H, Orstavik, J W, Vaupel

Publikováno v: Annals of the New York Academy of Sciences. 954

Despite differences in research traditions, the disciplines of genetics, epidemiology, and demography are becoming increasingly integrated in health-related research. The enormous development within genetic technology, with the possibility of genotyp

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https://pubmed.ncbi.nlm.nih.gov/11797856

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Response

Autor: J. R. Carey, J. W. Curtsinger, J. W. Vaupel

Publikováno v: Science. 260:1567-1569

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a03630a22a4bc23a886631962a2ef3f9
https://doi.org/10.1126/science.260.5114.1567-a

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Estimation of apolipoprotein E genotype-specific relative mortality risks from the distribution of genotypes in centenarians and middle-aged men: apolipoprotein E gene is a 'frailty gene,' not a 'longevity gene'

Autor: L U, Gerdes, B, Jeune, K A, Ranberg, H, Nybo, J W, Vaupel

Publikováno v: Genetic epidemiology. 19(3)

We developed a method to estimate genotype-specific average relative mortality risk, R, from genotype distributions in cross-sectional studies of people belonging to different age-groups, and applied the method to new data from a study of apolipoprot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ee5b2d8cb0e6152b26e761ea02aa099d
https://pubmed.ncbi.nlm.nih.gov/11015124

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The genetic component of discrete disability traits: an analysis using liability models with age-dependent thresholds

Autor: A I, Yashin, I A, Iachine, K, Christensen, N V, Holm, J W, Vaupel

Publikováno v: Behavior genetics. 28(3)

The presence of familial and genetic effects in the Activities-of-Daily-Life (ADL) data collected in the first wave of the 1995 Longitudinal Study of Aging of Danish Twins (LSADT) older than 75 is tested using multithreshold liability models of disab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::efcde2b3b574ddbdb00e63cf1f59d547
https://pubmed.ncbi.nlm.nih.gov/9670596

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