Zobrazeno 1 - 10
of 72
pro vyhledávání: '"J. W. Shay"'
Autor:
W. L. Ng, G. Chen, M. Wang, H. Wang, M. Story, J. W. Shay, X. Zhang, J. Wang, A. R. M. R. Amin, B. Hu, F. A. Cucinotta, Y. Wang
Publikováno v:
Cell Death and Disease, Vol 13, Iss 3, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/cc35ee476f5241cfbd86dbcdb56440b4
Autor:
C, Schäfer, A, Mohan, W, Burford, M K, Driscoll, A T, Ludlow, W E, Wright, J W, Shay, G, Danuser
Publikováno v:
Convergent science physical oncology. 2(3)
Oncogenic Kras mutations are important drivers of lung cancer development and metastasis. They are known to activate numerous cellular signaling pathways implicated in enhanced proliferation, survival, tumorigenicity and motility during malignant pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ff73647588fe7bc548d66715cd912f9f
https://pubmed.ncbi.nlm.nih.gov/29057096
https://pubmed.ncbi.nlm.nih.gov/29057096
Autor:
K Hiyama, Y Hirai, S Kyoizumi, M Akiyama, E Hiyama, M A Piatyszek, J W Shay, S Ishioka, M Yamakido
Publikováno v:
The Journal of Immunology. 155:3711-3715
This is the first report describing up-regulation of telomerase activity in human normal cells. Telomerase, a ribonucleoprotein enzyme, has been thought to be involved in maintaining telomere length stability in germline and most cancer cells, but no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f32c18870404ebd1ac680624c9fdfae7
https://doi.org/10.4049/jimmunol.155.8.3711
https://doi.org/10.4049/jimmunol.155.8.3711
Autor:
Jennifer, Condon, Su, Yin, Bobbie, Mayhew, R Ann, Word, W E, Wright, J W, Shay, William E, Rainey
Publikováno v:
Biology of reproduction. 67(2)
Several strategies have been described for the primary culture of human myometrial cells. However, primary cultures of myometrial cells have a limited life span, making continual tissue acquisition and cell isolation necessary. Recent studies have de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5b16c798d4015524a52a8ee318731c4
https://pubmed.ncbi.nlm.nih.gov/12135889
https://pubmed.ncbi.nlm.nih.gov/12135889
Autor:
T, Komata, Y, Kondo, T, Kanzawa, S, Hirohata, S, Koga, H, Sumiyoshi, S M, Srinivasula, B P, Barna, I M, Germano, M, Takakura, M, Inoue, E S, Alnemri, J W, Shay, S, Kyo, S, Kondo
Publikováno v:
Cancer research. 61(15)
Because the apoptotic pathway is often disrupted in tumor cells, its genetic restoration is a very attractive approach for the treatment of tumors. To treat malignant gliomas with this approach, it would be preferred to restrict induction of apoptosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::762bc613f0a49039a2ad98dba06e771e
https://pubmed.ncbi.nlm.nih.gov/11479218
https://pubmed.ncbi.nlm.nih.gov/11479218
Autor:
J W, Shay, W E, Wright
Publikováno v:
Novartis Foundation symposium. 235
Telomeres are repetitive DNA sequences at the ends of linear chromosomes. Telomerase, a cellular reverse transcriptase, helps stabilize telomere length in human stem, reproductive and cancer cells by adding TTAGGG repeats onto the telomeres. Each tim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d02cfc7b15b4bbbe900eb4bf57a4a4bb
https://pubmed.ncbi.nlm.nih.gov/11280022
https://pubmed.ncbi.nlm.nih.gov/11280022
Autor:
J W, Shay, W E, Wright
Publikováno v:
Science (New York, N.Y.). 291(5505)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd58b9196b8a9685abe7fbc56d38b2aa
https://pubmed.ncbi.nlm.nih.gov/11157166
https://pubmed.ncbi.nlm.nih.gov/11157166
High telomerase activity is an independent prognostic indicator of poor outcome in colorectal cancer
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(7)
Telomerase activity and altered telomere length have been extensively studied in many kinds of malignant tumors for clinical diagnostic and/or prognostic utilities. In the present study, we investigated telomerase activity and telomere length in colo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0a02a2b1d35418e8b6e8fb352c408482
https://pubmed.ncbi.nlm.nih.gov/10914712
https://pubmed.ncbi.nlm.nih.gov/10914712
Publikováno v:
Biology of reproduction. 61(2)
We have previously postulated that granulosa cells of developing follicles arise from a population of stem cells. Stem cells and cancer cells can divide indefinitely partly because they express telomerase. Telomerase is a ribonucleoprotein enzyme tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0eb399d8a75d93e61acbe6fb3db60f59
https://pubmed.ncbi.nlm.nih.gov/10411512
https://pubmed.ncbi.nlm.nih.gov/10411512
Publikováno v:
Journal of cellular physiology. 180(1)
Telomerase is a cellular reverse transcriptase that helps to provide genomic stability in highly proliferative normal, immortal, and tumor cells by maintaining the integrity of the chromosome ends, the telomeres. The activity of telomerase is associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f8f38294b032efcc75d651b5c66ce69e
https://pubmed.ncbi.nlm.nih.gov/10362013
https://pubmed.ncbi.nlm.nih.gov/10362013