Zobrazeno 1 - 9 of 9 pro vyhledávání: '"J. W. Proksch"'
1
SB-242235, a selective inhibitor of p38 mitogen-activated protein kinase. II: In vitro and in vivo metabolism studies and pharmacokinetic extrapolation to man
Autor: Brian R. Smith, Keith W. Ward, J. W. Proksch, M. A. Levy, C.-P. Yu, B. D. Bush, Peter D. Gorycki, May Y. K. Ho
Publikováno v: Xenobiotica. 32:235-250
1. Inhibition of p38 MAP kinase has been investigated extensively as a potential therapy for cytokine-mediated diseases such as autoimmune and inflammatory diseases. SB-242235 (1-(4-piperidinyl)-4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl) imidazol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025b2487aa720d19b891030018a96290
https://doi.org/10.1080/00498250110100711
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2
SB-242235, a selective inhibitor of p38 mitogenactivated protein kinase. I: Preclinical pharmacokinetics
Autor: J A Morgan, Kevin L. Salyers, M. A. Levy, Keith W. Ward, Brian R. Smith, J E McSurdy-Freed, Theresa J. Roethke, J. W. Proksch, Leonard M. Azzarano
Publikováno v: Xenobiotica. 32:221-233
1. SB-242235 (1-(4-piperidinyl)-4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl) imidazole) is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases such as autoimmune or inflammatory diseases.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d378a6fd64664acfd7d852a9eef0e083
https://doi.org/10.1080/00498250110100720
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3
SB-239063, a potent and selective inhibitor of p38 map kinase: preclinical pharmacokinetics and species-specific reversible isomerization
Autor: K W, Ward, J W, Proksch, L M, Azzarano, K L, Salyers, J E, McSurdy-Freed, T M, Molnar, M A, Levy, B R, Smith
Publikováno v: Pharmaceutical research. 18(9)
A series of studies was conducted to evaluate the preclinical pharmacokinetics of SB-239063 (trans-1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-5-[(2-methoxy)pyrimidin-4-yl] imidazole), a potent and selective p38 MAP kinase inhibitor.SB-239063 was admi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::53db7bcb88850cd6a7fd0d3f6ff65d58
https://pubmed.ncbi.nlm.nih.gov/11683250
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5
Development of an in vivo preclinical screen model to estimate absorption and bioavailability of xenobiotics
Autor: K W, Ward, J W, Proksch, M A, Levy, B R, Smith
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(1)
The purpose of this study was to develop an in vivo screening method for rapid preclinical characterization of absorption and bioavailability of large numbers of compounds. This effort involved several steps. First, a pharmacokinetic characterization
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c476635236fc9b94c1b4870bb4e2fdf2
https://pubmed.ncbi.nlm.nih.gov/11124234
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6
The effect of rate of drug administration on the extent and time course of phencyclidine distribution in rat brain, testis, and serum
Autor: J W, Proksch, W B, Gentry, S M, Owens
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 28(7)
The goal of these studies was to examine the relationship between the rate of phencyclidine (PCP) administration and PCP tissue distribution. The time course of PCP distribution in serum, brain, and testis after rapid (i.v.) and slow (s.c.) administr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::076a65d836a3a6d2c1faa5759d0686a4
https://pubmed.ncbi.nlm.nih.gov/10859146
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7
Anti-phencyclidine monoclonal antibodies provide long-term reductions in brain phencyclidine concentrations during chronic phencyclidine administration in rats
Autor: J W, Proksch, W B, Gentry, S M, Owens
Publikováno v: The Journal of pharmacology and experimental therapeutics. 292(3)
These studies examined the hypothesis that a single large dose of monoclonal anti-phencyclidine (PCP) antibody could provide long-term reductions in brain PCP concentrations despite continuous PCP administration. PCP (18 mg/kg/day, s.c.) was infused
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9870044b5de44c30f0a5f62ec7c76f0a
https://pubmed.ncbi.nlm.nih.gov/10688594
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8
Pharmacodynamics of a monoclonal antiphencyclidine Fab with broad selectivity for phencyclidine-like drugs
Autor: J S, Hardin, W D, Wessinger, J W, Proksch, S M, Owens
Publikováno v: The Journal of pharmacology and experimental therapeutics. 285(3)
The development of treatment strategies for drug intoxication has been hindered in part by the lack of clinically useful antagonists. Consequently, the major goal of these studies was to determine whether a monoclonal antibody Fab fragment (of IgG) c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0040a873ddc5dbfe088e9cbced85ac23
https://pubmed.ncbi.nlm.nih.gov/9618414
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9
Nitric oxide generation by renal proximal tubules: role of nitric oxide in the cytotoxicity of lipid A
Autor: L A, Traylor, J W, Proksch, V C, Beanum, P R, Mayeux
Publikováno v: The Journal of pharmacology and experimental therapeutics. 279(1)
Lipid A, the biologically active component of lipopolysaccharide, stimulated nitric oxide (NO) production by isolated rat proximal tubules (as measured by NO2- release) in a time-dependent manner. At a concentration of 50 micrograms/ml, lipid A stimu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::666fe32607bf3485d047f7249d96d559
https://pubmed.ncbi.nlm.nih.gov/8858980
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