Zobrazeno 1 - 9
of 9
pro vyhledávání: '"J. W. Leone"'
Autor:
A. M. Mildner, R. L. Heinrikson, H. D. Fischer, J. M. Lull, Thomas L. Emmons, Alfredo G. Tomasselli, J. W. Leone
Publikováno v:
Protein & Peptide Letters. 16:121-131
Evidence for a key role of beta-amyloid (Abeta) in Alzheimer's disease has led to considerable interest in potential therapeutic strategies targeting enzymes involved in processing the amyloid precursor protein (APP). Beta-site APP Cleaving Enzyme (B
Autor:
A. Tomasselli, D. Paddock, T. Emmons, A. Mildner, J. Leone, J. Lull, J. Cialdella, D. Prince, H. Fischer, R. Heinrikson, T. Benson, A. G. Tomasselli, D. J. Paddock, T. L. Emmons, A. M. Mildner, J. W. Leone, J. M. Lull, J. I. Cialdella, D. B. Prince, H. D. Fischer, R. L. Heinrikson, T. E. Benson
Publikováno v:
Protein & Peptide Letters. 15:131-143
BACE (beta-site APP cleaving enzyme) or beta-secretase, the enzyme responsible for processing APP to give the N-terminal portion of the Abeta peptide, is a membrane bound aspartyl protease consisting of an ectodomain catalytic unit, a C-terminal tran
Autor:
R S, Thoma, J S, Smith, W, Sandoval, J W, Leone, P, Hunziker, B, Hampton, K D, Linse, N D, Denslow
Publikováno v:
Journal of biomolecular techniques : JBT. 20(4)
The Edman Sequence Research Group (ESRG) of the Association of Biomolecular Resource designs and executes interlaboratory studies investigating the use of automated Edman degradation for protein and peptide analysis. In 2008, the ESRG enlisted the he
Autor:
A. Tomasselli, T. Emmons, M. Shuck, M. Babcock, J. Holloway, J. Leone, J. Durbin, D. Paddock, D. Prince, R. Heinrikson, H. Fischer, M. Bienkowski, T. Benson, T. L. Emmons, M. E. Shuck, M. S. Babcock, J. S. Holloway, J. W. Leone, J. D. Durbin, D. J. Paddock, D. B. Prince, R. L. Heinrikson, H. D. Fischer, M. J. Bienkowski, T. E. Benson, A. G. Tomasselli
Publikováno v:
Protein and peptide letters. 15(2)
BACE, or beta-secretase, is an attractive target in the treatment of Alzheimer's Disease because of its involvement in the generation of amyloid beta peptides. BACE is a type I transmembrane aspartyl protease composed of pre-, pro-, catalytic, transm
Autor:
D, Brune, N D, Denslow, R, Kobayashi, W S, Lane, J W, Leone, B J, Madden, J M, Neveu, J, Pohl
Publikováno v:
Journal of biomolecular techniques : JBT. 17(5)
Identification of modified amino acids can be a challenging part for Edman degradation sequence analysis, largely because they are not included among the commonly used phenylthiohydantion amino acid standards. Yet many can have unique retention times
Autor:
K A, Koeplinger, Z, Zhao, T, Peterson, J W, Leone, F S, Schwende, R L, Heinrikson, A G, Tomasselli
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(9)
In preclinical pharmacokinetic studies and in in vitro rat, dog, and human primary hepatocyte incubations, the sulfonamide (-NH-SO(2)-) bond of a potent inhibitor of the HIV-1 protease containing the p-cyanopyridinyl moiety (PNU-109112), undergoes me
Autor:
A G, Tomasselli, A A, Mildner, D J, Paddock, J S, Wheeler, T M, Kubiak, R A, Martin, W M, Moseley, J E, Mott, M C, White, J W, Leone, R L, Heinrikson
Publikováno v:
Biotechnology and applied biochemistry. 26(1)
An autolysis-resistant mutant of the HIV-I protease was employed for removal of metabolically stabilized and highly bioactive analogues of bovine growth-hormone-releasing factor (bGRF) from their larger either synthetic or recombinant precursors. The
Autor:
N, Fan, K B, Rank, J W, Leone, R L, Heinrikson, C A, Bannow, C W, Smith, D B, Evans, S M, Poppe, W G, Tarpley, D J, Rothrock
Publikováno v:
The Journal of biological chemistry. 270(22)
Active, recombinant p68 reverse transcriptase (RT) from human immunodeficiency virus type 2 (HIV-2), with an NH2-terminal extension containing a hexahistidine sequence was isolated from extracts of Escherichia coli by immobilized metal affinity chrom
Publikováno v:
Peptide research. 7(3)
The presence of Val2 in mGRF(1-42)OH is unique and, as shown in this study, renders this GRF resistant to plasma DPP-IV, the main enzyme responsible for rapid hydrolysis and inactivation of Ala2-containing GRFs from other species via cleavages betwee