Výsledky vyhledávání - "J. W. Hanifin"

Preparation of triazolo[1,5-c]pyrimidines as potential antiasthma agents

Autor: W. A. Hallett, M. E. Tarrant, L. W. Torley, Rolf Paul, J. S. Baker, J. W. Hanifin, Robert A. Hardy, J. B. Medwid, Brockman Ja, M. T. Du

Publikováno v: Journal of medicinal chemistry. 33(4)

With the use of the human basophil histamine release assay, 5-aryl-2-amino[1,2,4]triazolo[1,5-c]pyrimidines were found to be active as mediator release inhibitors. These compounds were prepared by reacting arylamidines with sodium ethyl formylacetate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c52bcc3e9232a68f7cabde2e8874f4dc
https://pubmed.ncbi.nlm.nih.gov/1969485

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Imidazo[1,5-d][1,2,4]triazines as potential antiasthma agents

Autor: F. M. Callahan, Bernard Dean Johnson, Rolf Paul, Hallett Wa, M. E. Tarrant, L. W. Torley, J. W. Hanifin, P. F. Fabio, Robert H. Lenhard, Brockman Ja

Publikováno v: Journal of medicinal chemistry. 28(11)

By using inhibition of histamine release from antigen-challenged, sensitized human basophils as a means of identifying a potentially prophylactic drug for the treatment of asthma, a series of substituted imidazo[1,5-d][1,2,4]triazines were found, whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee826eadef01969c496b72996e787d2c
https://pubmed.ncbi.nlm.nih.gov/2415706

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