Výsledky vyhledávání - "J. W. Gorrod"

Effect of the nicotine metabolite 5'-hydroxycotinine on glucose transport and glycogen synthase activity in rat skeletal muscle

Autor: Jeffrey W. Ryder, Dana Galuska, J. W. Gorrod, Yuichi Kawano, Harriet Wallberg-Henriksson, Jorge Rincon, Juleen R. Zierath

Publikováno v: Pfl�gers Archiv European Journal of Physiology. 439:130-133

Cigarette smoke contains many potentially harmful substances, including nicotine and nicotine metabolites, which are likely to contribute to altered glucose homeostasis. We determined the effects of nicotine and nicotine derivatives on glucose transp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8f5679ef08c9ab8c0bda94e58b7639
https://doi.org/10.1007/s004240051136

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[Untitled]

Autor: J. W. Gorrod, Jim Fang

Publikováno v: Cellular and Molecular Neurobiology. 19:491-510

1. Antipsychotic drugs are extensively metabolised by cytochrome P450 (CYP) enzymes. 2. Dispositions of a number of antipsychotic drugs have been shown to cosegregate with polymorphism of CYP2D6. 3. Metabolic drug–drug interactions have frequently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5c2632052967545249ff376bc1a47bc
https://doi.org/10.1023/a:1006938908284

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Inhibition of monoamine oxidases by haloperidol and its metabolites: pharmacological implications for the chemotherapy of schizophrenia

Autor: Peter H. Yu, Alan A. Boulton, Jim Fang, J W Gorrod

Publikováno v: Psychopharmacology. 118:206-212

The effect of haloperidol and its metabolites on human platelet monoamine oxidase B (MAO-B) and human placenta monoamine oxidase A (MAO-A) in vitro has been investigated. We found that 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-pyridinium (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ca228026075cd1f7b3abf83fc6deb8
https://doi.org/10.1007/bf02245841

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Comutagenesis-II. Some factors influencing the in vitro metabolism of 2-amino-3-methylpyridine

Autor: J W Gorrod, T G Altuntas

Publikováno v: Drug metabolism and drug interactions. 13(4)

Factors affecting the metabolism of 2-amino-3-methylpyridine (2A3MP) in vitro have been studied and the conditions which allow maximal metabolism established. Ring nuclear and methyl hydroxylation, and 1-N-oxidation of 2A3MP were linear with respect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a5e9408088a7ac05c832e1bc964e4e
https://pubmed.ncbi.nlm.nih.gov/21568805

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Metabolic N-oxidation of 9-benzyladenine and isomeric 9-(nitrobenzyl)adenines by hamster hepatic microsomes

Autor: D Y, Liu, J W, Gorrod

Publikováno v: Drug metabolism and drug interactions. 13(3)

The metabolism of 9-benzyladenine (BA) and isomeric 9-(nitrobenzyl) adenines (NBAs), i.e. 9-(2-nitrobenzyl)adenine (2NBA), 9-(3-nitrobenzyl)adenine (3NBA) and 9-(4-nitrobenzyl)adenine (4NBA), was investigated with normal hamster hepatic microsomes. U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::92838f3c48e2eeddfb3f7050d0d8ec20
https://pubmed.ncbi.nlm.nih.gov/21568811

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The enzymology of the in–vitro oxidation of prolintane to oxoprolintane

Autor: J. W. Gorrod, M. C. Whittlesea

Publikováno v: Journal of Clinical Pharmacy and Therapeutics. 18:357-364

SUMMARY Studies to investigate the location of the enzymes responsible for oxoprolintane formation from prolintane, a sympathomimetic amine which is used to stimulate appetite, are reported. Aldehyde oxidase, cytochrome P–450 and flavin monooxygena

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6d4d8960be02d9107b4cf2943d1efac
https://doi.org/10.1111/j.1365-2710.1993.tb00603.x

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On the metabolism of haloperidol

Autor: J W Gorrod, Jim Fang

Publikováno v: Xenobiotica. 23:495-508

1. p-Fluorobenzoyl-propionic acid, 4-(4-chlorophenyl)-4-hydroxy-piperidine, and reduced haloperidol were confirmed as metabolites of haloperidol. Their formation was catalysed by hepatic microsomes and was NADPH dependent. 2. The pyridinium metabolit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75280a2566d322b0201b62820a84715d
https://doi.org/10.3109/00498259309059390

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ChemInform Abstract: The Synthesis of 1′-N-Methyl-2′-oxoanabasine, an Analogue of Cotinine

Autor: A. J. Hutt, J. W. Gorrod, G. Aislaitner

Publikováno v: ChemInform. 25

The synthesis of 1′-N-methyl-2′-oxoanabasine, a hepatic microsomal metabolite of 1′-N-methylanabasine is described. Treatment of 1′-N-methylanabasine with bromine yielded an intermediate geminal dibrominated derivative, the structure of which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17bda64f204178054db0606291b17b02
https://doi.org/10.1002/chin.199431265

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NICOTINE AND THE TOBACCO ALKALOIDS

Autor: M.-C. Tsai, J. W. Gorrod

Publikováno v: Molecules of Death ISBN: 9781860941276
Molecules of Death
Molecules of Death ISBN: 9781860948145

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa19ba404a7c5309dc08f7e89c7075a
https://doi.org/10.1142/9781860944536_0009

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Metabolism, pharmacogenetics, and metabolic drug-drug interactions of antipsychotic drugs

Autor: J, Fang, J W, Gorrod

Publikováno v: Cellular and molecular neurobiology. 19(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5625abfb6d593efc125b0de1292858a6
https://pubmed.ncbi.nlm.nih.gov/10379422

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