Výsledky vyhledávání - "J. W. Forstrom"

Thrombopoietin accelerates platelet, red blood cell, and neutrophil recovery in myelosuppressed mice

Autor: A, Grossmann, J, Lenox, H P, Ren, J M, Humes, J W, Forstrom, K, Kaushansky, K H, Sprugel

Publikováno v: Experimental hematology. 24(10)

The recent cloning of thrombopoietin (TPO) has allowed us to study its in vivo effects in normal and myelosuppressed mice. Normal Balb/c mice were treated with recombinant human TPO (hTPO) at doses ranging from 1 to 20 kU for 7 days, and complete blo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9a8fad97931b726f209e2adfe456c85f
https://pubmed.ncbi.nlm.nih.gov/8765500

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Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy

Autor: V. C. Broudy, J. Humes, K. H. Sprugel, N Lin, M. C. Bailey, T. Papayannopoulou, A. Grossmann, J. W. Forstrom, Kenneth Kaushansky, Hong Ping Ren

Publikováno v: The Journal of clinical investigation. 96(3)

Thrombopoietin (TPO), the ligand for the receptor protooncogene c-mpl, has been cloned and shown to be the critical regulator of platelet production. Several features of c-Mpl expression, including its presence on erythroid cell lines, and the panmye

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4107c43bee809b0bc0bd9e15664f686
https://pubmed.ncbi.nlm.nih.gov/7657840

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Identification of two neutrophil chemotactic peptides produced by porcine alveolar macrophages

Autor: R B, Goodman, J W, Forstrom, S G, Osborn, E Y, Chi, T R, Martin

Publikováno v: The Journal of biological chemistry. 266(13)

We have purified to homogeneity two distinct 10-kDa proteins with potent chemotactic activity for neutrophils from porcine alveolar macrophages incubated for 24 h with Escherichia coli endotoxin (lipopolysaccharide (LPS), 10 micrograms/ml). Neutrophi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c6a202cfc0b569a5bebcc8ad414ff2a2
https://pubmed.ncbi.nlm.nih.gov/1850745

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Two Different Subunits Associate to Create Isoform-Specific Platelet-derived Growth Factor Receptors

Autor: Russell Ross, Paul E. M. Phillips, Ronald A. Seifert, J W Forstrom, Charles E. Hart, Daniel F. Bowen-Pope, Mark J. Murray

Publikováno v: Journal of Biological Chemistry. 264:8771-8778

Recent evidence has demonstrated that there is more than one form of platelet-derived growth factor (PDGF) receptor and that these receptors differ in their specificity for the multiple isoforms of PDGF. We present evidence that high affinity binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1dad5b8047406c2a856065889e1a9124
https://doi.org/10.1016/s0021-9258(18)81860-9

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Donor substrate specificity and thiol reduction of glutathione disulfide peroxidase

Autor: A L Tappel, J W Forstrom

Publikováno v: Journal of Biological Chemistry. 254:2888-2891

By isolation of a mixed disulfide product of glutathione and cysteine, glutathione peroxidase was shown to be highly specific for only one donor substrate. Using the coupled assay of NADPH and yeast glutatione reductase, which is highly specific for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f25ef3100c12d337138a6ef38aa7090
https://doi.org/10.1016/s0021-9258(17)30156-4

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Immunotherapy of murine sarcomas with auto-anti-idiotypic monoclonal antibodies which bind to tumor-specific T cells

Autor: K A Nelson, E George, C Swenson, J W Forstrom, K E Hellström

Publikováno v: The Journal of Immunology. 139:2110-2117

Hybridomas producing monoclonal antibodies (mAb) were obtained from BALB/c mice immunized against either of two transplanted, chemically induced syngeneic sarcomas, MCA-1490 or MCA-1511. Two mAb, 4.72 and 5.96, were obtained, one from each immunizati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90fdc61624998f63352d89563cdd911d
https://doi.org/10.4049/jimmunol.139.6.2110

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Production of T-cell lines with inhibitory or stimulatory activity against syngeneic tumorsin vivo. A preliminary report

Autor: E. George, J. J. Mulé, J. W. Forstrom, Ingegerd Hellström, Karl Erik Hellström

Publikováno v: International Journal of Cancer. 28:611-614

We obtained Thy-I-positive cells directly from growing methylcholanthrene-induced (MCA-1510) sarcomas using fluorescence-activated cell sorting, then cultured these lymphocytes in medium containing Interleukin-2 and tested their activity in vivo agai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a67116508dafc4fe2a9b3378779d382a
https://doi.org/10.1002/ijc.2910280513

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Immunization to a syngeneic sarcoma by a monoclonal auto-anti-idiotypic antibody

Autor: Ingegerd Hellström, Karl Erik Hellström, Gerald T. Nepom, J. W. Forstrom, K. A. Nelson

Publikováno v: Nature. 303(5918)

Idiotypic networks regulate the immune response to a variety of antigens1–3. Antibodies generated against other antibodies, called anti-idiotypic antibodies, can themselves mimic antigen and elicit a specific immune response. They have been shown t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::814fb0273a506e58b406c464d60ba593
https://pubmed.ncbi.nlm.nih.gov/6190090

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