Zobrazeno 1 - 10
of 109
pro vyhledávání: '"J. W. Berg"'
Autor:
André M. M. Miltenburg, Marita Prohn, Renger G. Tiessen, Jacqueline H. M. van Kuijk, Martin de Kort, Rob J. W. Berg
Publikováno v:
British Journal of Clinical Pharmacology. 75:1221-1230
Aim Conjugation to antithrombin III ATIII-binding pentasaccharides has been proposed as a novel method to extend the half-life of therapeutic proteins. We aim to validate this technological concept in man by performing a first-in-human study using Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::703d7d259ebd386b1f009a31a8f4a9c6
https://doi.org/10.1111/j.1365-2125.2012.04460.x
https://doi.org/10.1111/j.1365-2125.2012.04460.x
Autor:
André M. M. Miltenburg, Jolanda H.G.M. Brands, C. Marco Timmers, Ralf Plate, Rob J W Berg, Willem-Jan Karstens, J. Robert Lane, Paolo Conti, Tanja A.E. van Achterberg, Monique G.A. van Amstel, Marcel E. de Gooyer, Chris J. van Koppen, Jesse W.Y. Wat
Publikováno v:
British Journal of Pharmacology. 165:2314-2324
BACKGROUND AND PURPOSE Graves' disease (GD) is an autoimmune disease in which the thyroid is overactive, producing excessive amounts of thyroid hormones, caused by thyroid-stimulating hormone (TSH) receptor-stimulating immunoglobulins (TSIs). Many GD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dccfa568616983f52ee5a564bfd72aa8
https://doi.org/10.1111/j.1476-5381.2011.01709.x
https://doi.org/10.1111/j.1476-5381.2011.01709.x
Autor:
Rob J. W. Berg
Publikováno v:
Encyclopedia of Cancer ISBN: 9783642278419
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c1e1319f4f75aba25311d1214fc600
https://doi.org/10.1007/978-3-642-27841-9_6280-2
https://doi.org/10.1007/978-3-642-27841-9_6280-2
Autor:
R. J. W. Berg, Frank R. de Gruijl
Publikováno v:
Photochemistry and Photobiology. 68:555-560
In UV carcinogenesis there is a fundamental chain of causal events from UV-induced DNA damage through mutations up to tumor formation: each of the early events should be predictive of the ultimate tumor risk. Instead of the UV surface exposure, the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6914d859fe08921155df67bc01f9a41b
https://doi.org/10.1111/j.1751-1097.1998.tb02513.x
https://doi.org/10.1111/j.1751-1097.1998.tb02513.x
Autor:
Hans Morreau, Harry van Steeg, Marinus Duran, Alan R. Lehmann, R. J. W. Berg, Geert Weeda, Pim Visser, Jan de Wit, Jan de Boer, Jane H.J. Hoeijmakers
Publikováno v:
Molecular Cell, 1, 981-990. Cell Press
The sun-sensitive form of the severe neurodevelopmental, brittle hair disorder trichothiodystrophy (TTD) is caused by point mutations in the essential XPB and XPD helicase subunits of the dual functional DNA repair/basal transcription factor TFIIH. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d603ac78ff7490ee1b758d6a12d91dbe
https://doi.org/10.1016/s1097-2765(00)80098-2
https://doi.org/10.1016/s1097-2765(00)80098-2
Autor:
H. van Steeg, C. F. Van Kreijl, Peter J.A. Capel, Anja Westerman, P. W. Wester, F.R. de Gruijl, R. J. W. Berg, Susan W.P. Wijnhoven, H.J. van Kranen, A. De Vries
Publikováno v:
Oncogene. 16:2205-2212
Xeroderma pigmentosum (XP) patients with a defect in the nucleotide excision repair gene XPA, develop tumors with a high frequency on sun-exposed areas of the skin. Here we describe that hairless XPA-deficient mice also develop skin tumors with a sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c84b41054983eb9ad8a278a28e75350e
https://doi.org/10.1038/sj.onc.1201744
https://doi.org/10.1038/sj.onc.1201744
Autor:
R. J. W. Berg, A. De Vries, F.R. de Gruijl, C. F. Van Kreijl, Nicolas Dumaz, P. W. Wester, H.J. van Kranen, Leela Daya-Grosjean, Alain Sarasin
Publikováno v:
Carcinogenesis. 18:897-904
Mutation spectra of the p53 gene from human skin carcin- process that involves many modifications including proto-omas have been connected to solar UV radiation. For oncogenes and tumor suppressor genes. Among these, the p53comparison we have charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac77eacf71fd3429dcd14b1a3c251659
https://doi.org/10.1093/carcin/18.5.897
https://doi.org/10.1093/carcin/18.5.897
Autor:
Marjan L. F. Jagt-Smook, Steven Ramael, Justin Dennie, Pierre A. M. Peeters, Michiel W. van den Heuvel, Pieter-Jan de Kam, Rob J. W. Berg, Guy Cammu, Peter Grobara
Publikováno v:
Clinical drug investigation. 33(8)
We evaluated the potential for QT/corrected QT (QTc) interval prolongation after sugammadex given with propofol or sevoflurane anaesthesia. This was a two-factorial, randomized, parallel-group study in 132 healthy subjects. Anaesthesia was maintained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab886695592a9718b3c683dbe2404cb
https://pubmed.ncbi.nlm.nih.gov/23824662
https://pubmed.ncbi.nlm.nih.gov/23824662
Publikováno v:
British Journal of Cancer
In this study the kinetics and localisation of protoporphyrin IX (PpIX) fluorescence in skin and skin tumours were examined after topically (20% for 4h) or systemically (200 mg/kg,i.p.) administered 5-aminolaevulinic acid (ALA). As a model we used ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5100260ad8471196934862339d778e
https://doi.org/10.1038/bjc.1996.165
https://doi.org/10.1038/bjc.1996.165
Publikováno v:
Carcinogenesis. 16:2455-2459
Cyclobutane pyrimidine dimers (CPD) are the predominant DNA lesions induced by UV-B radiation, among these lesions thymine dimers are most frequent. Although UV-A radiation may also induce CPD, it has been found that equally cytotoxic or equally muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0a87287a6d257c2ef165bf48e93b67
https://doi.org/10.1093/carcin/16.10.2455
https://doi.org/10.1093/carcin/16.10.2455