Prevalence and Incidence of Non-neutralizing Antibodies in Congenital Hemophilia A— A Systematic Review and Meta-Analysis

Autor: A. Abdi, M. R. Bordbar, S. Hassan, F. R. Rosendaal, J. G. van der Bom, J. Voorberg, K. Fijnvandraat, S. C. Gouw

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Objectives: In hemophilia A the presence of non-neutralizing antibodies (NNAs) against Factor VIII (FVIII) may predict the development of neutralizing antibodies (inhibitors) and accelerate the clearance of administrated FVIII concentrates. This syst

Externí odkaz: https://doaj.org/article/bc4e38a9c0724061ab28a8543f7fff23

The Activated Pulmonary Endothelium of Chronic Thromboembolic Pulmonary Hypertension Patients Exhibits Elevated Platelet Adhesion

Autor: J. Voorberg, Xiaoke Pan, P.L. Hordijk, Petr Symersky, Olga Tura-Ceide, J. Majolee, Robert Szulcek, Herman J Bogaard, X. D. Manz

Publikováno v: American Journal of Respiratory and Critical Care Medicine, 201. American Thoracic Society
Manz, X D, Pan, X, Symersky, P, Majolee, J, Tura-Ceide, O, Hordijk, P L, Voorberg, J, Bogaard, H J & Szulcek, R 2020, ' The Activated Pulmonary Endothelium of Chronic Thromboembolic Pulmonary Hypertension Patients Exhibits Elevated Platelet Adhesion ', American Journal of Respiratory and Critical Care Medicine, vol. 201 .

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a617839f44c3c6e28c0efe6175d48e2
https://research.vumc.nl/en/publications/5c8b33d3-ea28-4046-8983-697c8e8f338d

Longitudinal Analysis of Factor VIII Inhibitors in a Previously Untreated Mild Haemophilia A Patient with an Arg593→Cys Substitution

Autor: C. M. C. Bank, Ellen A. M. Turenhout, J. Voorberg, E. N. Van Den Brink, S. M. H. Timmermans, Karin Fijnvandraat, M. Peters

Publikováno v: Thrombosis and Haemostasis. 81:723-726

SummaryRecent studies suggest that certain missense mutations associated with mild to moderate haemophilia A predispose to inhibitor development. In this study, we present a longitudinal analysis of the epitope specificity of an inhibitor that develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57544272969b3a4d86f1a90079e32cca
https://doi.org/10.1055/s-0037-1614561

Domain specificity of factor VIII inhibitors during immune tolerance induction in patients with haemophilia A

Autor: P M W, van Helden, P H P, Kaijen, E P, Mauser-Bunschoten, K, Fischer, H M, van den Berg, J, Voorberg

Publikováno v: Haemophilia : the official journal of the World Federation of Hemophilia. 16(6)

Frequent administration of high dosages factor VIII (FVIII), so-called immune tolerance induction (ITI), provides an efficient strategy to eradicate inhibitory antibodies in patients with haemophilia A. At present, our knowledge on the characteristic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::af598ef14a9ebffd1883098f553227be
https://pubmed.ncbi.nlm.nih.gov/20491952

Impact of inhibitor epitope profile on the neutralizing effect against plasma-derived and recombinant factor VIII concentrates in vitro

Autor: J, Astermark, J, Voorberg, H, Lenk, D, DiMichele, A, Shapiro, G, Tjönnfjord, E, Berntorp

Publikováno v: Haemophilia : the official journal of the World Federation of Hemophilia. 9(5)

The inhibitory capacity of plasma samples from 24 patients with severe haemophilia A and high-responding inhibitors were evaluated in a concentrate-based assay using two plasma-derived (Haemate and Monoclate-P) and three recombinant (Helixate, Recomb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a1a9181b7b5e09a855097a10a468075a
https://pubmed.ncbi.nlm.nih.gov/14511295