Výsledky vyhledávání

Increased levels of enzymes involved in local estradiol synthesis in chronic obstructive pulmonary disease

Autor: Fien M. Verhamme, Niki L. Reynaert, Juanita H. J. Vernooy, Guy Brusselle, Ken R. Bracke, B. Delvoux, Gonda Konings, Andrea Romano

Publikováno v: Molecular and Cellular Endocrinology, 443(C), 23-31. Elsevier Ireland Ltd
Europe PubMed Central

Introduction: Steroid hormones are involved in lung development, pulmonary inflammation, and lung cancer. Estrogen signaling and exposure may play a role in pulmonary disorders, including COPD. In both genders, estrogens can be generated locally in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e109b93b557bb629c52ff0176c618c81
https://doi.org/10.1016/j.mce.2016.12.001

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Akademický článek

Suppressed pulmonary expression of leptin in lipopolysaccharide-induced acute and chronic lung inflammation

Autor: J. H. J. Vernooy, R. H. E. Cloots, M. A. Dentener, E. F. M. Wouters

Publikováno v: European Respiratory Review, Vol 15, Iss 101, Pp 207-208 (2006)

Leptin, originally described as an adipocyte-derived hormone regulating energy expenditure, is now classified as a type I cytokine. We and others recently demonstrated that the lung is an additional source of leptin. The aim of the present study was

Externí odkaz: https://doaj.org/article/465cfa9baab8438a82346c418e80fc79

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Optimising experimental research in respiratory diseases: an ERS statement

Publikováno v: European Respiratory Journal
European Respiratory Journal, European Respiratory Society, 2018, 51 (5), pp.1702133. ⟨10.1183/13993003.02133-2017⟩
European Respiratory Journal, 51(5):1702133. European Respiratory Society

Experimental models are critical for the understanding of lung health and disease and are indispensable for drug development. However, the pathogenetic and clinical relevance of the models is often unclear. Further, the use of animals in biomedical r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75644f2f0d1f25b40fd848bf7c2af848
https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01996906

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A comparative study of matrix remodeling in chronic models for COPD; mechanistic insights into the role of TNF-α

Autor: Niki L. Reynaert, Juanita H. J. Vernooy, Mieke A. Dentener, Emiel F.M. Wouters, Evi M. Mercken, Ken R. Bracke, Irene M. J. Eurlings, Rafael de Cabo

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology, 307(7), L557-L565. American Physiological Society

Remodeling in chronic obstructive pulmonary disease (COPD) has at least two dimensions: small airway wall thickening and destruction of alveolar walls. Recently we showed comparable alterations of the extracellular matrix (ECM) compounds collagen, hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2106d9e4e10c8b0e9d15efd3912420c3
https://cris.maastrichtuniversity.nl/en/publications/c6f6c14e-ddde-4e0d-9126-71f71614b245

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The Role of Leptin in the Development of Pulmonary Neutrophilia in Infection and Acute Lung Injury

Autor: Matthew J. Wargo, Jan Tavernier, Catherine Hayes, Katie R. Poch, Estee Dilli, Matthew E. Poynter, Lennart Zabeau, Juanita H. J. Vernooy, Edward Abraham, Niki D.J. Ubags, Elianne Burg, Mercedes Rincon, Oliver Dienz, Jenna Bement, Benjamin T. Suratt, Joaquín Zúñiga, Jerry A. Nick, Joseph P. Mizgerd, Emiel F.M. Wouters

Publikováno v: Critical Care Medicine, 42(2), e143-e151. LIPPINCOTT WILLIAMS & WILKINS

OBJECTIVES: One of the hallmarks of severe pneumonia and associated acute lung injury is neutrophil recruitment to the lung. Leptin is thought to be up-regulated in the lung following injury and to exert diverse effects on leukocytes, influencing bot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643440cfd86a6a800bd1dabb3d2da3b7
https://cris.maastrichtuniversity.nl/en/publications/a21ee743-db4d-47f4-adfc-3d18c10437a9

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Interferon-beta induces a long-lasting antiviral state in human respiratory epithelial cells

Autor: Giel R. Gaajetaan, Gernot Rohde, Frank R. M. Stassen, Cathrien A. Bruggeman, Niki L. Reynaert, Juanita H. J. Vernooy, Erik V. Beuken, Gert Grauls, Mieke A. Dentener, Tanja H. Geelen

Publikováno v: Journal of Infection, 66(2), 163-169. Elsevier Saunders

OBJECTIVES: Interferon-beta (IFNbeta) induces strong antiviral effects and is therefore an attractive agent to prevent or reduce the incidence of virus-mediated exacerbations in asthmatic or chronic obstructive pulmonary disease (COPD) patients. We t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f28788b381e24dd23e07d775f0fb85
https://doi.org/10.1016/j.jinf.2012.11.008

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Hyperleptinemia is associated with impaired pulmonary host defense

Autor: Benjamin T. Suratt, Jan Tavernier, Catherine M. Hayes, Renee D. Stapleton, Niki D.J. Ubags, Matthew J. Wargo, S. Ventrone, Matthew E. Poynter, Emiel F.M. Wouters, Elianne Burg, Polly E. Parsons, Benjamin Littenberg, Juanita H. J. Vernooy, Anne E. Dixon, Lennart Zabeau, Jenna Bement

Publikováno v: JCI INSIGHT, 1(8):e82101. American Society for Clinical Investigation

We have previously reported that obesity attenuates pulmonary inflammation in both patients with acute respiratory distress syndrome (ARDS) and in mouse models of the disease. We hypothesized that obesity-associated hyperleptinemia, and not body mass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dbc302caf245f233d21c3835d941256
https://cris.maastrichtuniversity.nl/en/publications/90bb37a2-8057-4e26-a93b-c31617174eda

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Granzyme A impairs host defense during Streptococcus pneumoniae pneumonia

Autor: Tom van der Poll, Marieke A. D. van Zoelen, Alex F. de Vos, Joris J. T. H. Roelofs, Juanita H. J. Vernooy, Klaas P. J. M. van Gisbergen, Cornelis van 't Veer, Louis Boon, Florry E. van den Boogaard, Jan Paul Medema, Douwe H. Biesma, Henrik Endeman

Publikováno v: American journal of physiology. Lung cellular and molecular physiology, 311(2), L507-L516. American Physiological Society
American Journal of Physiology-Lung Cellular and Molecular Physiology, 311(2), L507-L516. American Physiological Society

Streptococcus pneumoniae is the most common causative pathogen in community-acquired pneumonia (CAP). Granzyme A (GzmA) is a serine protease produced by a variety of cell types involved in the immune response. We sought to determine the role of GzmA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7865143775cf22e8c4675a6228520f33
https://pure.amc.nl/en/publications/granzyme-a-impairs-host-defense-during-streptococcus-pneumoniae-pneumonia(10951b45-ec4e-4a6f-82a6-3a3f3ecaa41b).html

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