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Akademický článek

Scalable, semi-automated fluorescence reduction neutralization assay for qualitative assessment of Ebola virus-neutralizing antibodies in human clinical samples.

Autor: Elena N Postnikova, James Pettitt, Collin J Van Ryn, Michael R Holbrook, Laura Bollinger, Shuǐqìng Yú, Yíngyún Caì, Janie Liang, Michael C Sneller, Peter B Jahrling, Lisa E Hensley, Jens H Kuhn, Mosoka P Fallah, Richard S Bennett, Cavan Reilly

Publikováno v: PLoS ONE, Vol 14, Iss 8, p e0221407 (2019)

Antibody titers against a viral pathogen are typically measured using an antigen binding assay, such as an enzyme-linked immunosorbent assay (ELISA), which only measures the ability of antibodies to identify a viral antigen of interest. Neutralizatio

Externí odkaz: https://doaj.org/article/e7bb89cec8f840be8b1e3ed7a18f48ff

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Rapid determination of anticoagulating effects of dabigatran in whole blood with rotational thromboelastometry and a thrombin‐based trigger

Autor: V. Taune, Håkan Wallén, Anna Ågren, J. van Ryn, Agneta Wikman, Mika Skeppholm, Rickard E. Malmström, Gunilla Gryfelt

Publikováno v: Journal of Thrombosis and Haemostasis. 16:2462-2470

Essentials A rapid test to detect thrombin inhibition by dabigatran would be valuable in acute situations. A thrombin-based trigger was applied in whole blood using rotation thromboelastometry. Effects of dabigatran were assessed in vitro and in samp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3194815ddd2d5ab1e2378f41dbd885
https://doi.org/10.1111/jth.14308

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The addition of idarucizumab to plasma samples containing dabigatran allows the use of routine coagulation assays for the diagnosis of hemostasis disorders

Autor: J Schoeters, Peter Verhamme, M. Debasse, Jaan Toelen, I. Van Horenbeeck, Thomas Vanassche, Marijke Peetermans, J. van Ryn, Marc Jacquemin, Kathelijne Peerlinck, I. Vanlinthout

Publikováno v: Journal of Thrombosis and Haemostasis. 13:2087-2092

Summary Background The anticoagulant effect of dabigatran can be approximated by its prolongation of routine coagulation assays. Consequently, dabigatran also interferes with thrombophilia screening or with diagnosing hemostasis disorders that have d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ef0c6cd50539e886b36c922d9670a3
https://doi.org/10.1111/jth.13138

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Akademický článek

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Reversal of dabigatran anticoagulation by prothrombin complex concentrate (Beriplex P/N) in a rabbit model

Autor: Baerbel Doerr, S. H. Zeitler, Gerhard Dickneite, Franz Kaspereit, Ingo Pragst, Eva Herzog, J. van Ryn

Publikováno v: Journal of Thrombosis and Haemostasis. 10:1841-1848

Summary. Background: One limitation of the direct thrombin inhibitor dabigatran is the lack of specific antidotes that allow acute bleeding events to be managed or urgent interventional procedures performed. Prothrombin complex concentrates (PCCs) ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077cf4f43b5d24156e3e594ecb9f509a
https://doi.org/10.1111/j.1538-7836.2012.04859.x

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Fibrin formation by staphylothrombin facilitates Staphylococcus aureus-induced platelet aggregation

Autor: Olaf Schneewind, Peter Verhamme, J. van Ryn, Thomas Vanassche, Jan Verhaegen, Alexandre Kauskot, Marc Hoylaerts, Willy Peetermans

Publikováno v: Thrombosis and Haemostasis. 107:1107-1121

SummaryInteractions of Staphylococcus aureus (S. aureus) and platelets play an important role in the pathogenesis of intravascular infections such as infective endocarditis (IE). A typical feature of S. aureus is the ability to generate thrombin acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2ab5640b5abdb6297cc3741aa340ab
https://doi.org/10.1160/th11-12-0891

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Akademický článek

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Experimental models used to investigate the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2 by non-steroidal anti-inflammatory drugs

Autor: J. van Ryn, Michel Pairet

Publikováno v: Inflammation Research. 47:93-101

Numerous in vitro assays have been developed for testing and comparing the relative inhibitory activities of non-steroidal anti-inflammatory drugs against cyclooxygenase (COX)-1 and COX-2. Despite variability among these systems, which precludes dire

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514e902bbe2371ad713a3f6541da3b2a
https://doi.org/10.1007/s000110050289

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Portable gamma spectrometry system for simultaneous monitoring of radiotracers in vivo using CdTe and CdZnTe radiation detector probes

Autor: M. Markert, H. Merk, J. van Ryn, M. Lorenz, Wolfgang Eisert

Publikováno v: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 353:448-452

A portable gamma spectrometry system has been designed to simultaneously monitor various radiotracers in vivo. This system includes a portable IBM® compatible personal computer and miniaturized gamma radiation detector probes based on the semiconduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a32ef7dd8f1d1fbab5021e1b866d01e
https://doi.org/10.1016/0168-9002(94)91696-9

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