Zobrazeno 1 - 9 of 9 pro vyhledávání: '"J. V. Tuttle"'
1
Inhibition of Influenza A and B Viruses by 2′-Deoxy-2′-Fluororibosides
Autor: K. L. Powell, Margaret Tisdale, G. Darby, G. Appleyard, D. J. Nelson, D. J. M. Purifoy, W. Al Nakib, J. N. Stables, J. V. Tuttle, S. Nusinoff-Lehrman
Publikováno v: Antiviral Chemistry and Chemotherapy. 4:281-287
A series of 2′-deoxy-2′-fluororibosides were evaluated for anti-influenza activity in cell culture and in the mouse pneumonia model. Many were found to be potent inhibitors of Influenza A, in chick embryo fibroblast cells (IC50's 0.1–2.9 μM),
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c87d772299a233145593d336e2fefaa9
https://doi.org/10.1177/095632029300400504
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2
Nucleotide analogue inhibitors of purine nucleoside phosphorylase
Autor: T A, Krenitsky, J V, Tuttle, W H, Miller, A R, Moorman, G F, Orr, L, Beauchamp
Publikováno v: The Journal of biological chemistry. 265(6)
The diphosphate of the antiherpetic agent acyclovir [9-[(2-hydroxyethoxy)methyl]guanine] has been shown to inhibit purine nucleoside phosphorylase with unique potency (Tuttle, J. V., and Krenitsky, T. A. (1984) J. Biol. Chem. 259, 4065-4069). A major
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a92956ab72f9a8d8d5e9671181efe292
https://pubmed.ncbi.nlm.nih.gov/2105941
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3
Effects of acyclovir and its metabolites on purine nucleoside phosphorylase
Autor: T A Krenitsky, J V Tuttle
Publikováno v: Journal of Biological Chemistry. 259:4065-4069
Acyclovir (9-(2-hydroxyethoxymethyl)guanine), the clinically useful antiherpetic agent, is an "acyclic" analogue of 2'-deoxyguanosine. Purine nucleoside phosphorylase partially purified from human erythrocytes did not catalyze detectable phosphorolys
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ceafad09d7a48789aa2e9ae85b71f8ea
https://doi.org/10.1016/s0021-9258(17)43009-2
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5
Effects of acyclovir and its metabolites on purine nucleoside phosphorylase
Autor: J V, Tuttle, T A, Krenitsky
Publikováno v: The Journal of biological chemistry. 259(7)
Acyclovir (9-(2-hydroxyethoxymethyl)guanine), the clinically useful antiherpetic agent, is an "acyclic" analogue of 2'-deoxyguanosine. Purine nucleoside phosphorylase partially purified from human erythrocytes did not catalyze detectable phosphorolys
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3966aa2fcbab05985414a38a7fa2f1fb
https://pubmed.ncbi.nlm.nih.gov/6423639
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8
Deoxycytidine kinase from calf thymus. Substrate and inhibitor specificity
Autor: T A, Krenitsky, J V, Tuttle, G W, Koszalka, I S, Chen, L M, Beacham, J L, Rideout, G B, Elion
Publikováno v: The Journal of biological chemistry. 251(13)
Kinetic constants were determined for 34 nucleoside substrates of deoxycytidine kinase (EC 2.7.1.74) from calf thymus. Substrate efficiency was assessed by the ratio of Vmax to Km. Inhibition constants were determined for 61 nonsubstrate nucleosides
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bdacf5ad3f247f70ae09d7bc3818b912
https://pubmed.ncbi.nlm.nih.gov/932021
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