Zobrazeno 1 - 10
of 52
pro vyhledávání: '"J. V. N. Vara Prasad"'
Autor:
Jiashi Wang, John D. Baird, Neil Gregory Almstead, Marla Weetall, Yi Jin Kim Gorske, Jean Hedrick, Jana Narasimhan, Aleksey I. Gerasyuto, Tamil Arasu, Srinivasa Peddi, Wu Du, Michael Arnold, Josephine Sheedy, Gary Mitchell Karp, Stanley W. Lue, Guy Lagaud, Arthur Branstrom, J. V. N. Vara Prasad, Ginzburg Olya
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(22)
The continued emergence of bacteria resistant to current standard of care antibiotics presents a rapidly growing threat to public health. New chemical entities (NCEs) to treat these serious infections are desperately needed. Herein we report the disc
Autor:
Vladimir Khlebnikov, J. V. N. Vara Prasad, Mike Stier, Frederick E. Boyer, Samarendra N. Maiti
Publikováno v:
Synthesis. 2007:3858-3862
The synthesis of a series of pyrazole, isoxazole, and aminopyrimidine ring-fused benzothiocycloheptane-derived oxazolidinones and their corresponding sulfone derivatives is described.
Autor:
J V N, Vara Prasad
Publikováno v:
Current Opinion in Microbiology. 10:454-460
Due to the emergence of resistance to known antibiotics to various organisms, for example, Staphylococcus, Streptococcus, Enterococci, and Pseudomonas there is a renewed interest in the discovery of new antibacterials. Oxazolidinones, totally synthet
Publikováno v:
Tetrahedron Letters. 41:4065-4068
Thiocyanation of anilines was used to introduce a thiol functionality and to construct the aminothiazole ring, all in a single step. A systematic study of thiocyanation of alkyl anilines was investigated to understand the regiochemistry of the reacti
Autor:
Larry J. Markoski, Stephen J. Gracheck, Carolyn Nouhan, Peter J. Tummino, Steven VanderRoest, James Saunders, J. V. N. Vara Prasad, Krishna R. Iyer, Christopher Gajda, Fred E. Boyer, Donna Ferguson, Elizabeth A. Lunney, John M. Domagala, Bradley Dean Tait, Michael Sinz, Donald Hupe, Tod P. Holler, Susan Elizabeth Hagen, Edmund L. Ellsworth
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2217-2222
Dihydropyran-2-one possessing a sulfamate moiety at the 4-position of the thiophenyl ring were designed to reach S 3 ′ pocket of the HIV protease. Synthetic routes for the preparation of thiotosylates possessing 3-(2- t -butyl-5-methyl-4-sulfamate)
Autor:
J. V. N. Vara Prasad, Donald Hupe, Elizabeth A. Lunney, John M. Domagala, Donna Ferguson, Greg Zeikus, Neil Graham, Peter J. Tummino, Susan Elizabeth Hagen, Caroline Nouhan, Tod P. Holler, Edmund L. Ellsworth
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2019-2024
5,6-Dihydro-2H-pyran-2-ones are potent inhibitors of HIV-1 protease, which bind to the S1, S2, S1', and S2' pockets and have a unique binding mode with the catalytic aspartyl groups and the flap region of the enzyme. Efforts to explore 3-position het
Autor:
Peter J. Tummino, James Saunders, Stephen J. Gracheck, Bradley Dean Tait, J. V. N. Vara Prasad, Joanne I. Brodfuehrer, Christopher Andrew Gajda, Krishna R. Iyer, Tod P. Holler, Susan Elizabeth Hagen, Steven VanderRoest, Edmund L. Ellsworth, Fred E. Boyer, Carolyn Nouhan, Donna Ferguson, Larry James Markoski, Michael Sinz, Donald Hupe, Elizabeth A. Lunney, John M. Domagala
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1481-1486
Dihydropyran-2-ones possessing amino and carboxamide functionalities on 3-SPh (2-tert-butyl, 5-methyl) ring were synthesized and evaluated for their antiviral activities. Both the enantiomers of inhibitor 15 were synthesized. The in vitro resistance
Autor:
Elizabeth A. Lunney, Frederick E. Boyer, J. V. N. Vara Prasad, Stephen J. Gracheck, Carolyn Nouhan, Edmund L. Ellsworth, Bradley Dean Tait, Donna Ferguson, Susan Elizabeth Hagen, Steven VanderRoest, Larry J. Markoski, James Saunders, Harriet W. Hamilton, B. A. Steinbaugh, Peter J. Tummino, John M. Domagala, Donald Hupe, Christopher Gajda
Publikováno v:
Journal of Medicinal Chemistry. 40:3707-3711
Autor:
John W. Erickson, Donald Hupe, Eric T. Baldwin, J. R. Rubin, and Sergei V. Gulnik, Christine Humblet, Susan Elizabeth Hagen, Christopher Gajda, Harriet W. Hamilton, Carolyn Nouhan, Beishan Liu, J. V. N. Vara Prasad, Neil Graham, Edmund L. Ellsworth, Peter J. Tummino, John M. Domagala, Alexander Pavlovsky, Donna Ferguson, Elizabeth A. Lunney, T. N. Bhat, Bradley Dean Tait, Stephen J. Gracheck
Publikováno v:
Journal of Medicinal Chemistry. 40:3781-3792
The 4-hydroxy-5,6-dihydropyrone template was utilized as a flexible scaffolding from which to build potent active site inhibitors of HIV protease. Dihydropyrone 1c (5,6-dihydro-4-hydroxy-6-phenyl-3-[(2-phenylethyl)thio]-2H-pyran-2-one) was modeled in
Autor:
Patricia J. Harvey, Michael Andrew Stier, William G. Rice, Rocco D. Gogliotti, Yuntao Song, Steve Gracheck, Peter J. Tummino, Tod P. Holler, John M. Domagala, Joseph P. Sanchez, Robert R. Schultz, John P. Bader, J. V. N. Vara Prasad, Jeffrey D. Scholten, Donald Hupe
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:569-579
As part of the National Cancer Institute's Drug Screening Program, a new class of antiretrovirals active against the human immunodeficiency virus HIV-1 has been identified, and the HIV-1 nucleocapsid protein NCp7 was proposed as the target of antivir