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Akademický článek

MicroRNA-212-5p, an anti-proliferative miRNA, attenuates hypoxia and sugen/hypoxia-induced pulmonary hypertension in rodents

Autor: Tianji Chen, Miranda R. Sun, Qiyuan Zhou, Alyssa M. Guzman, Ramaswamy Ramchandran, Jiwang Chen, Dustin R. Fraidenburg, Balaji Ganesh, Mark Maienschein-Cline, Karl Obrietan, J. Usha Raj

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 204-216 (2022)

MicroRNAs (miRNA, miR-) play important roles in disease development. In this study, we identified an anti-proliferative miRNA, miR-212-5p, that is induced in pulmonary artery smooth muscle cells (PASMCs) and lungs of pulmonary hypertension (PH) patie

Externí odkaz: https://doaj.org/article/ed4623300a804178a3a77b18297d3b42

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Akademický článek

Extracellular vesicles derived from endothelial cells in hypoxia contribute to pulmonary artery smooth muscle cell proliferation in‐vitro and pulmonary hypertension in mice

Autor: Tianji Chen, Miranda R. Sun, Qiyuan Zhou, Alyssa M. Guzman, Ramaswamy Ramchandran, Jiwang Chen, Balaji Ganesh, J. Usha Raj

Publikováno v: Pulmonary Circulation, Vol 12, Iss 1, Pp n/a-n/a (2022)

Abstract In the lung, communication between pulmonary vascular endothelial cells (PVEC) and pulmonary artery smooth muscle cells (PASMC) is essential for the maintenance of vascular homeostasis. In pulmonary hypertension (PH), the derangement in thei

Externí odkaz: https://doaj.org/article/8c4516715deb40d7b76699cd3f45aaf4

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Akademický článek

Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia

Autor: Viswanathan Natarajan, Alison W. Ha, Yangbasai Dong, Narsa M. Reddy, David L. Ebenezer, Prasad Kanteti, Sekhar P. Reddy, J. Usha Raj, Zhengdeng Lei, Mark Maienschein-Cline, Zarema Arbieva, Anantha Harijith

Publikováno v: BMC Genomics, Vol 18, Iss 1, Pp 1-16 (2017)

Abstract Background Sphingosine- 1-Phosphate (S1P) is a bioactive lipid and an intracellular as well as an extracellular signaling molecule. S1P ligand specifically binds to five related cell surface G-protein-coupled receptors (S1P1-5). S1P levels a

Externí odkaz: https://doaj.org/article/e8337ad8f6fe428cb408d96f38224e0d

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Akademický článek

Phosphatidylinositol 3‐Kinase–DNA Methyltransferase 1–miR‐1281–Histone Deacetylase 4 Regulatory Axis Mediates Platelet‐Derived Growth Factor–Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells

Autor: Yanjiao Li, Li Li, Zhengjiang Qian, Boya Lin, Jidong Chen, Yixuan Luo, Junle Qu, J. Usha Raj, Deming Gou

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 6 (2018)

BackgroundPlatelet‐derived growth factor BB, a potent mitogen of pulmonary artery smooth muscle cells (PASMCs), has been implicated in pulmonary arterial remodeling, which is a key pathogenic feature of pulmonary arterial hypertension. Previous mic

Externí odkaz: https://doaj.org/article/0737ed6d65354c3180a13951eb744c43

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Akademický článek

miR‐17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia‐Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation

Autor: Tianji Chen, Qiyuan Zhou, Haiyang Tang, Melike Bozkanat, Jason X.‐J. Yuan, J. Usha Raj, Guofei Zhou

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 12 (2016)

BackgroundPreviously we found that smooth muscle cell (SMC)‐specific knockout of miR‐17~92 attenuates hypoxia‐induced pulmonary hypertension. However, the mechanism underlying miR‐17~92‐mediated pulmonary artery SMC (PASMC) proliferation re

Externí odkaz: https://doaj.org/article/0590166fbbf34008baee1dc7dc1f8f55

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Akademický článek

Consenso sobre la clasificación de la enfermedad vascular pulmonar hipertensiva en niños: Reporte del task force pediátrico del Pulmonary Vascular Research Institute (PVRI) Panamá 2011

Autor: María Jesús del Cerro, Steven Abman, Gabriel Díaz, Alexandra Heath Freudenthal, Franz Freudenthal, S. Harikrishnan, Sheila G. Haworth, Dunbar Ivy, Antonio A. Lopes, J. Usha Raj, Julio Sandoval, Kurt Stenmark, Ian Adatia

Publikováno v: Revista Colombiana de Cardiología, Vol 19, Iss 6, Pp 339-352 (2012)

Las clasificaciones actuales de la hipertensión pulmonar han contribuido significativamente al conocimiento de la enfermedad vascular pulmonar, han facilitado ensayos farmacológicos y han mejorado nuestro conocimiento de las cardiopatías congénit

Externí odkaz: https://doaj.org/article/e91d1ecd6d43482f9ddf8c8f683beeb8

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Akademický článek

Clasificación funcional de la hipertensión pulmonar en niños: Informe del task force pediátrico del Pulmonary Vascular Research Institute (PVRI), Panamá 2011

Autor: Astrid E. Lammers, Ian Adatia, María Jesús del Cerro, Gabriel Díaz, Alexandra Heath Freudenthal, Franz Freudenthal, S. Harikrishnan, Dunbar Ivy, Antonio A. Lopes, J. Usha Raj, Julio Sandoval, Kurt Stenmark, Sheila G. Haworth

Publikováno v: Revista Colombiana de Cardiología, Vol 19, Iss 6, Pp 332-338 (2012)

Los miembros del Task Force pediátrico del Pulmonary Vascular Research Institute (PVRI, su sigla en Inglés) fueron conscientes de la necesidad de desarrollar una clasificación funcional de la hipertensión pulmonar en niños. La clasificación que

Externí odkaz: https://doaj.org/article/8eb21e36bf1c429883f72665f61fdf4b

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