Zobrazeno 1 - 10
of 61
pro vyhledávání: '"J. U. Raj"'
Publikováno v:
Journal of Lipid Research, Vol 37, Iss 4, Pp 783-789 (1996)
The metabolism of platelet activating factor (PAF) by lungs of near-term fetal and 5- to 9-day-old lambs was studied during normoxia and hypoxia at 37 degrees C in 30 mM Tris buffer. PAF synthesis was studied in lung cytosol and membrane using 250 mi
Externí odkaz:
https://doaj.org/article/26ac14b0d2c3441db089d033795519b0
Publikováno v:
Medical Research Archives. 8
We studied effect of chronic hypoxia (CH) on expression of platelet activating factor receptor (PAFR) by neonatal rats (pups). We hypothesized that PAFR antagonist will prevent pulmonary hypertension (PH) in pups exposed to CH. Pups were placed in an
Publikováno v:
Cell Proliferation. 46:654-664
Objective Pulmonary arterial hypertension, characterized by pulmonary vascular remodelling and vasoconstriction, is associated with excessive proliferative changes in pulmonary vascular walls. However, the role of HDACs in the phenotypic alteration o
Publikováno v:
Cell Proliferation. 45:335-344
Recent studies have indicated a role of epigenetic phenomena in pathogenesis of pulmonary hypertension, but in foetal pulmonary artery smooth muscle cell (PASMC) proliferation this is still largely unknown. G9a is a key enzyme for histone H3 dimethyl
Publikováno v:
Cell Proliferation. 41:208-229
Objective Platelet-activating factor (PAF) is implicated in pathogenesis of persistent pulmonary hypertension of the neonate (PPHN); PAF is a mitogen for lung fibroblasts. PAF's role in pulmonary vascular smooth muscle cell (PVSMC) proliferation and
Publikováno v:
British Journal of Pharmacology. 153:497-507
Background and purpose: The cGMP-dependent protein kinase (PKG) is a key enzyme for nitrovasodilator-induced vasodilation. The present study was to determine its role in nitrate tolerance. Experimental approach: isolated porcine coronary arteries wer
Publikováno v:
British Journal of Pharmacology. 152:1060-1069
Background and purpose: Coronary venous activity is modulated by endogenous and exogenous nitrovasodilators. The present study was to determine the role of protein kinase G (PKG) in the regulation of the basal tension and nitrovasodilator-induced rel
Publikováno v:
Molecular Genetics and Metabolism. 65:229-237
The transition from fetal to newborn life is marked by a reduction in pulmonary vascular tone mediated by the intracellular second messengers, cGMP and cAMP. We have compared the rates of phosphodiesterase (PDE)-catalyzed hydrolysis of cGMP and cAMP
Publikováno v:
Cell Proliferation.
Objectives Platelet-activating factor (PAF) is produced by pulmonary vascular smooth muscle cells (PVSMC). We studied effects of Rho kinase on PAF stimulation of PVSMC proliferation in an attempt to understand the role of RhoA/Rho kinase on PAF-induc