Zobrazeno 1 - 10
of 77
pro vyhledávání: '"J. Tyson McDonald"'
Autor:
J. Tyson McDonald, JangKeun Kim, Lily Farmerie, Meghan L. Johnson, Nidia S. Trovao, Shehbeel Arif, Keith Siew, Sergey Tsoy, Yaron Bram, Jiwoon Park, Eliah Overbey, Krista Ryon, Jeffrey Haltom, Urminder Singh, Francisco J. Enguita, Victoria Zaksas, Joseph W. Guarnieri, Michael Topper, Douglas C. Wallace, Cem Meydan, Stephen Baylin, Robert Meller, Masafumi Muratani, D. Marshall Porterfield, Brett Kaufman, Marcelo A. Mori, Stephen B. Walsh, Dominique Sigaudo-Roussel, Saida Mebarek, Massimo Bottini, Christophe A. Marquette, Eve Syrkin Wurtele, Robert E. Schwartz, Diego Galeano, Christopher E. Mason, Peter Grabham, Afshin Beheshti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Our previous research revealed a key microRNA signature that is associated with spaceflight that can be used as a biomarker and to develop countermeasure treatments to mitigate the damage caused by space radiation. Here, we expand on this wo
Externí odkaz:
https://doaj.org/article/0649faa161fd46558b42240dde0a9327
Autor:
Henry Cope, Jonas Elsborg, Samuel Demharter, J. Tyson McDonald, Chiara Wernecke, Hari Parthasarathy, Hriday Unadkat, Mira Chatrathi, Jennifer Claudio, Sigrid Reinsch, Pinar Avci, Sara R. Zwart, Scott M. Smith, Martina Heer, Masafumi Muratani, Cem Meydan, Eliah Overbey, Jangkeun Kim, Christopher R. Chin, Jiwoon Park, Jonathan C. Schisler, Christopher E. Mason, Nathaniel J. Szewczyk, Craig R. G. Willis, Amr Salam, Afshin Beheshti
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-18 (2024)
Abstract Background Spaceflight poses a unique set of challenges to humans and the hostile spaceflight environment can induce a wide range of increased health risks, including dermatological issues. The biology driving the frequency of skin issues in
Externí odkaz:
https://doaj.org/article/ffa9a91797784258acddd144b101f342
Autor:
Tyler Beach, James Bakke, J. Tyson McDonald, Edward Riccio, Harold S. Javitz, Denise Nishita, Shweta Kapur, Deborah I. Bunin, Polly Y. Chang
Publikováno v:
Frontiers in Public Health, Vol 12 (2024)
IntroductionMouse models of radiation injury are critical to the development of medical countermeasures (MCMs) against radiation. Now that MCMs against hematopoietic acute radiation syndrome (H-ARS) have achieved regulatory approval, attention is shi
Externí odkaz:
https://doaj.org/article/593b139b37cc4a76a1dda96846470c62
Autor:
Arpita Chatterjee, Isin T. Sakallioglu, Divya Murthy, Elizabeth A. Kosmacek, Pankaj K. Singh, J. Tyson McDonald, Robert Powers, Rebecca E. Oberley-Deegan
Publikováno v:
Redox Biology, Vol 52, Iss , Pp 102301- (2022)
Radiation is a common anticancer therapy for prostate cancer, which transforms tumor-associated normal fibroblasts to myofibroblasts, resulting in fibrosis. Oxidative stress caused by radiation-mediated mitochondrial damage is one of the major contri
Externí odkaz:
https://doaj.org/article/de248751a416424f955a439bc4105347
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
Expanded implementation of genetic sequencing has precipitously increased the discovery of germline and somatic variants. The direct benefit of identifying variants in actionable genes may lead to risk reduction strategies such as increased surveilla
Externí odkaz:
https://doaj.org/article/842c1ffdf4d34f52a1ebe9cf9c871313
Autor:
J. Tyson McDonald, Francisco J. Enguita, Deanne Taylor, Robert J. Griffin, Waldemar Priebe, Mark R. Emmett, Mohammad M. Sajadi, Anthony D. Harris, Jean Clement, Joseph M. Dybas, Nukhet Aykin-Burns, Joseph W. Guarnieri, Larry N. Singh, Peter Grabham, Stephen B. Baylin, Aliza Yousey, Andrea N. Pearson, Peter M. Corry, Amanda Saravia-Butler, Thomas R. Aunins, Sadhana Sharma, Prashant Nagpal, Cem Meydan, Jonathan Foox, Christopher Mozsary, Bianca Cerqueira, Viktorija Zaksas, Urminder Singh, Eve Syrkin Wurtele, Sylvain V. Costes, Gustavo Gastão Davanzo, Diego Galeano, Alberto Paccanaro, Suzanne L. Meinig, Robert S. Hagan, Natalie M. Bowman, Matthew C. Wolfgang, Selin Altinok, Nicolae Sapoval, Todd J. Treangen, Pedro M. Moraes-Vieira, Charles Vanderburg, Douglas C. Wallace, Jonathan C. Schisler, Christopher E. Mason, Anushree Chatterjee, Robert Meller, Afshin Beheshti, Shannon M. Wallet, Robert Maile, Jason R. Mock, Jose L. Torres-Castillo, Miriya K. Love, Will Lovell, Colleen Rice, Olivia Mitchem, Dominique Burgess, Jessica Suggs, Jordan Jacobs
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109839- (2021)
Summary: MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation that have a major impact on many diseases and provide an exciting avenue toward antiviral therapeutics. From patient transcriptomic data, we determ
Externí odkaz:
https://doaj.org/article/86972322eb3c4fa78fa77d4ae3931268
Autor:
Dörthe Schaue, Ewa D. Micewicz, Josephine A. Ratikan, Keisuke S. Iwamoto, Erina Vlashi, J. Tyson McDonald, William H. McBride
Publikováno v:
Antioxidants, Vol 11, Iss 9, p 1649 (2022)
Nuclear factor erythroid 2-related factor 2 (NRF2) is recognized as a master transcription factor that regulates expression of numerous detoxifying and antioxidant cytoprotective genes. In fact, models of NRF2 deficiency indicate roles not only in re
Externí odkaz:
https://doaj.org/article/d93c14d74c3a4a43a4f52aa740921de6
Autor:
Eliah G. Overbey, Amanda M. Saravia-Butler, Zhe Zhang, Komal S. Rathi, Homer Fogle, Willian A. da Silveira, Richard J. Barker, Joseph J. Bass, Afshin Beheshti, Daniel C. Berrios, Elizabeth A. Blaber, Egle Cekanaviciute, Helio A. Costa, Laurence B. Davin, Kathleen M. Fisch, Samrawit G. Gebre, Matthew Geniza, Rachel Gilbert, Simon Gilroy, Gary Hardiman, Raúl Herranz, Yared H. Kidane, Colin P.S. Kruse, Michael D. Lee, Ted Liefeld, Norman G. Lewis, J. Tyson McDonald, Robert Meller, Tejaswini Mishra, Imara Y. Perera, Shayoni Ray, Sigrid S. Reinsch, Sara Brin Rosenthal, Michael Strong, Nathaniel J. Szewczyk, Candice G.T. Tahimic, Deanne M. Taylor, Joshua P. Vandenbrink, Alicia Villacampa, Silvio Weging, Chris Wolverton, Sarah E. Wyatt, Luis Zea, Sylvain V. Costes, Jonathan M. Galazka
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102361- (2021)
Summary: With the development of transcriptomic technologies, we are able to quantify precise changes in gene expression profiles from astronauts and other organisms exposed to spaceflight. Members of NASA GeneLab and GeneLab-associated analysis work
Externí odkaz:
https://doaj.org/article/db05f4c13f9d4050b634492f121e3d68
Autor:
Arpita Chatterjee, Elizabeth A. Kosmacek, Shashank Shrishrimal, J. Tyson McDonald, Rebecca E. Oberley-Deegan
Publikováno v:
Redox Biology, Vol 34, Iss , Pp 101542- (2020)
Radiation is a common anticancer therapy for many cancer patients, including prostate cancer. Diabetic prostate cancer patients suffer from increased lymph node metastasis, tumor recurrence and decreased survival as compared to non-diabetic prostate
Externí odkaz:
https://doaj.org/article/3a28a95800fd48d28adc1ec8d86b82c1
Autor:
Afshin Beheshti, J. Tyson McDonald, Megumi Hada, Akihisa Takahashi, Christopher E. Mason, Maddalena Mognato
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10507 (2021)
The space environment consists of a complex mixture of different types of ionizing radiation and altered gravity that represents a threat to humans during space missions. In particular, individual radiation sensitivity is strictly related to the risk
Externí odkaz:
https://doaj.org/article/88d27489f37643e3a3ce33d67171e9b9