Zobrazeno 1 - 10 of 203 pro vyhledávání: '"J. Tynan"'
1
Akademický článek
Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor
Autor: Jemima Ho, Xuexin Yang, Spyridoula-Angeliki Nikou, Nessim Kichik, Andrew Donkin, Nicole O. Ponde, Jonathan P. Richardson, Remi L. Gratacap, Linda S. Archambault, Christian P. Zwirner, Celia Murciano, Rhonda Henley-Smith, Selvam Thavaraj, Christopher J. Tynan, Sarah L. Gaffen, Bernhard Hube, Robert T. Wheeler, David L. Moyes, Julian R. Naglik
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Candida albicans is an opportunistic fungus primarily affecting immunocompromised patients. Here, the authors identify a novel mechanism of host immune stimulation and highlight candidalysin and EGFR signalling components as potential targets for pro
Externí odkaz: https://doaj.org/article/5a35ef4f63da4f5da3fd3d4b2fc4fa96
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2
Akademický článek
Feasibility and acceptability of strategies to address mental health and mental ill-health in the Australian coal mining industry
Autor: Ross J. Tynan, Carole James, Robyn Considine, Jaelea Skehan, Jorgen Gullestrup, Terry J. Lewin, John Wiggers, Brian J. Kelly
Publikováno v: International Journal of Mental Health Systems, Vol 12, Iss 1, Pp 1-10 (2018)
Abstract Background To evaluate the feasibility, acceptability and effectiveness of implementing a peer-based, multi-component mental health program in the Australian coal mining industry. Methods The multicomponent program included MATES in mining (
Externí odkaz: https://doaj.org/article/ef58f9c7173b420b8cf56904594c70e0
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3
Akademický článek
The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers
Autor: Laura C. Zanetti-Domingues, Dimitrios Korovesis, Sarah R. Needham, Christopher J. Tynan, Shiori Sagawa, Selene K. Roberts, Antonija Kuzmanic, Elena Ortiz-Zapater, Purvi Jain, Rob C. Roovers, Alireza Lajevardipour, Paul M. P. van Bergen en Henegouwen, George Santis, Andrew H. A. Clayton, David T. Clarke, Francesco L. Gervasio, Yibing Shan, David E. Shaw, Daniel J. Rolfe, Peter J. Parker, Marisa L. Martin-Fernandez
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
To prevent ligand-independent dimerisation the epidermal growth factor receptor (EGFR) is autoinhibited by an extracellular dimer interaction. Here, the authors use several imaging technologies and simulations to provide structural insights on the in
Externí odkaz: https://doaj.org/article/d8f1227aa2394ee08a80e9812006d6b2
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4
Akademický článek
3D visualization of additive occlusion and tunable full-spectrum fluorescence in calcite
Autor: David C. Green, Johannes Ihli, Paul D. Thornton, Mark A. Holden, Bartosz Marzec, Yi-Yeoun Kim, Alex N. Kulak, Mark A. Levenstein, Chiu Tang, Christophe Lynch, Stephen E. D. Webb, Christopher J. Tynan, Fiona C. Meldrum
Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Introducing organic guests to a crystal is a convenient way to tailor its properties. Here, the authors occlude fluorescent dyes within calcite to reveal that additives can occupy distinct zones of a crystal, and strategically embed green, blue, and
Externí odkaz: https://doaj.org/article/724c470570fe4508b101ca0330a81e59
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5
Akademický článek
EGFR oligomerization organizes kinase-active dimers into competent signalling platforms
Autor: Sarah R. Needham, Selene K. Roberts, Anton Arkhipov, Venkatesh P. Mysore, Christopher J. Tynan, Laura C. Zanetti-Domingues, Eric T. Kim, Valeria Losasso, Dimitrios Korovesis, Michael Hirsch, Daniel J. Rolfe, David T. Clarke, Martyn D. Winn, Alireza Lajevardipour, Andrew H. A. Clayton, Linda J. Pike, Michela Perani, Peter J. Parker, Yibing Shan, David E. Shaw, Marisa L. Martin-Fernandez
Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Epidermal growth factor receptors have been shown to oligomerise upon binding to their cognate ligands. Here, the authors use biochemical, biophysical and cell biology techniques to analyse the structures of these oligomers, and argue that these form
Externí odkaz: https://doaj.org/article/4106f1db16d64a39ab5d782e227f6e6e
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6
On the use of single, dual and three process langmuir models for binary gas mixtures that exhibit unique combinations of these processes
Autor: Kyle J. Tynan, Armin D. Ebner, Sofia Tosso, James A. Ritter
Publikováno v: Adsorption. 27:637-658
Two scenarios were investigated for predicting binary gas adsorption equilibria when the single gas isotherms of one component is described by the three process Langmuir (TPL) model and the single gas isotherms of the other component is described by
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01f80a0e7bee9fa3ce26026fc2645f59
https://doi.org/10.1007/s10450-021-00312-0
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7
Supramolecular clustering of the cardiac sodium channel Nav1.5 in HEK293F cells, with and without the auxiliary β3‐subunit
Autor: Antony P. Jackson, Alexandra McStea, Marisa L. Martin-Fernandez, Andrew J. Thompson, Johanna S. Rees, Christopher J. Tynan, Richard Butler, Lin Wang, Christopher L.-H. Huang, Jennifer R. Irons, Michael Hirsch, Matthew Reed, Samantha C. Salvage
Publikováno v: The FASEB Journal
Voltage‐gated sodium channels comprise an ion‐selective α‐subunit and one or more associated β‐subunits. The β3‐subunit (encoded by the SCN3B gene) is an important physiological regulator of the heart‐specific sodium channel, Nav1.5. W
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd29b61c875ccf26322ac59c526d765d
http://europepmc.org/articles/PMC7079131
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9
The guidance and adhesion protein FLRT2 dimerizes in cis via dual small-X
Autor: Verity, Jackson, Julia, Hermann, Christopher J, Tynan, Daniel J, Rolfe, Robin A, Corey, Anna L, Duncan, Maxime, Noriega, Amy, Chu, Antreas C, Kalli, E Yvonne, Jones, Mark S P, Sansom, Marisa L, Martin-Fernandez, Elena, Seiradake, Matthieu, Chavent
Publikováno v: Structure (London, England : 1993). 30(9)
Fibronectin Leucine-rich Repeat Transmembrane (FLRT 1-3) proteins are a family of broadly expressed single-spanning transmembrane receptors that play key roles in development. Their extracellular domains mediate homotypic cell-cell adhesion and heter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f0aa356d2598a488dcb684e4a8216d69
https://pubmed.ncbi.nlm.nih.gov/35700726
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10
On the use of the dual process Langmuir model for binary gas mixture components that exhibit single process or linear isotherms
Autor: Armin D. Ebner, Kathryn C. Bumiller, James A. Ritter, Kyle J. Tynan
Publikováno v: Adsorption. 25:1511-1523
Two methodologies were developed to predict adsorption equilibria of a binary system when one of the components is described by the dual-process Langmuir (DPL) model and the other component is described by either the single process Langmuir (SPL) or
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::703a32a1132097f93d75493b1576376f
https://doi.org/10.1007/s10450-019-00159-6
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