Zobrazeno 1 - 10
of 88
pro vyhledávání: '"J. Tursi"'
Autor:
Elizabeth M. Parzych, Jianqiu Du, Ali R. Ali, Katherine Schultheis, Drew Frase, Trevor R. F. Smith, Jiayan Cui, Neethu Chokkalingam, Nicholas J. Tursi, Viviane M. Andrade, Bryce M. Warner, Ebony N. Gary, Yue Li, Jihae Choi, Jillian Eisenhauer, Igor Maricic, Abhijeet Kulkarni, Jacqueline D. Chu, Gabrielle Villafana, Kim Rosenthal, Kuishu Ren, Joseph R. Francica, Sarah K. Wootton, Pablo Tebas, Darwyn Kobasa, Kate E. Broderick, Jean D. Boyer, Mark T. Esser, Jesper Pallesen, Dan W. Kulp, Ami Patel, David B. Weiner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Here, Parzych et al describe the development of a DNA-delivered SARS-CoV-2 mAb cocktail displaying synergistic RBD binding that confers broad neutralizing activity against variants of concern and prophylactic efficacy in multiple small animal models.
Externí odkaz:
https://doaj.org/article/dec1ebc23ee2448fb7ad32d2457e1b56
Autor:
Nicholas J. Tursi, Sophia M. Reeder, Yevel Flores-Garcia, Mamadou A. Bah, Shamika Mathis-Torres, Berenice Salgado-Jimenez, Rianne Esquivel, Ziyang Xu, Jacqueline D. Chu, Laurent Humeau, Ami Patel, Fidel Zavala, David B. Weiner
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Novel approaches for malaria prophylaxis remain important. Synthetic DNA-encoded monoclonal antibodies (DMAbs) are a promising approach to generate rapid, direct in vivo host-generated mAbs with potential benefits in production simplicity an
Externí odkaz:
https://doaj.org/article/2a9b0778593442f08dfbfe70da161a9c
Autor:
Ziyang Xu, Susanne Walker, Megan C. Wise, Neethu Chokkalingam, Mansi Purwar, Alan Moore, Edgar Tello-Ruiz, Yuanhan Wu, Sonali Majumdar, Kylie M. Konrath, Abhijeet Kulkarni, Nicholas J. Tursi, Faraz I. Zaidi, Emma L. Reuschel, Ishaan Patel, April Obeirne, Jianqiu Du, Katherine Schultheis, Lauren Gites, Trevor Smith, Janess Mendoza, Kate E. Broderick, Laurent Humeau, Jesper Pallesen, David B. Weiner, Daniel W. Kulp
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
HIV envelope is a target for vaccine development, but induction of broadly neutralizing antibodies has been difficult. Here, the authors show that electroporation with a synthetic DNA vaccine construct allows in vivo production of HIV envelope native
Externí odkaz:
https://doaj.org/article/35ba9a407faa49de8522273b74f5d21c
Autor:
Ami Patel, Jewell N. Walters, Emma L. Reuschel, Katherine Schultheis, Elizabeth Parzych, Ebony N. Gary, Igor Maricic, Mansi Purwar, Zeena Eblimit, Susanne N. Walker, Diana Guimet, Pratik Bhojnagarwala, Opeyemi S. Adeniji, Arthur Doan, Ziyang Xu, Dustin Elwood, Sophia M. Reeder, Laurent Pessaint, Kevin Y. Kim, Anthony Cook, Neethu Chokkalingam, Brad Finneyfrock, Edgar Tello-Ruiz, Alan Dodson, Jihae Choi, Alison Generotti, John Harrison, Nicholas J. Tursi, Viviane M. Andrade, Yaya Dia, Faraz I. Zaidi, Hanne Andersen, Mohamed Abdel-Mohsen, Mark G. Lewis, Kar Muthumani, J. Joseph Kim, Daniel W. Kulp, Laurent M. Humeau, Stephanie J. Ramos, Trevor R.F. Smith, David B. Weiner, Kate E. Broderick
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 10, Pp 100420- (2021)
Summary: Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, has had a dramatic global impact on public health and social and economic infrastructures. Here, we assess the immunogenicity and anamnestic protective efficacy in rhesus m
Externí odkaz:
https://doaj.org/article/b251aab9f925454e8c8c047ebbca4faa
Autor:
Ebony N. Gary, Bryce M. Warner, Elizabeth M. Parzych, Bryan D. Griffin, Xizhou Zhu, Nikesh Tailor, Nicholas J. Tursi, Mable Chan, Mansi Purwar, Robert Vendramelli, Jihae Choi, Kathy L. Frost, Sophia Reeder, Kevin Liaw, Edgar Tello, Ali R. Ali, Kun Yun, Yanlong Pei, Sylvia P. Thomas, Amira D. Rghei, Matthew M. Guilleman, Kar Muthumani, Trevor Smith, Sarah K. Wootton, Ami Patel, David B. Weiner, Darwyn Kobasa
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102699- (2021)
Summary: More than 100 million people have been infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Common laboratory mice are not susceptible to wild-type SARS-CoV-2 infection, challenging the development and testing of effec
Externí odkaz:
https://doaj.org/article/c729d41c6d47484fbcc09aab37def4d6
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The structural and functional destruction of the blood-testis barrier (BTB) following uropathogenic E. coli (UPEC) infection may be a critical component of the pathologic progress of orchitis. Recent findings indicate that the mammalian target of the
Externí odkaz:
https://doaj.org/article/119e8486daee4c74a11dde3e477003b4
Autor:
Pratik S. Bhojnagarwala, Ryan P. O’Connell, Daniel Park, Kevin Liaw, Ali R. Ali, Devivasha Bordoloi, Joel Cassel, Nicholas J. Tursi, Ebony Gary, David B. Weiner
Publikováno v:
Molecular Therapy - Oncolytics. 26:289-301
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70f4e1d9ee45575266e0a7ed482004a4
https://doi.org/10.1016/j.omto.2022.07.003
https://doi.org/10.1016/j.omto.2022.07.003
Autor:
David B. Weiner, Daniel W. Kulp, Laurent Humeau, Kate E. Broderick, Katherine Schultheis, Paul D. Fisher, Nicholas J. Tursi, Susanne Walker, Mamadou A. Bah, Megan C. Wise, Edgar Tello-Ruiz, Neethu Chokkalingam, Ziyang Xu
Cytolytic T cells (CTL) play a pivotal role in surveillance against tumors. Induction of CTL responses by vaccination may be challenging, as it requires direct transduction of target cells or special adjuvants to promote cross-presentation. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354b0c477e4497de823b57b781df1eab
https://doi.org/10.1158/2326-6066.c.6550372.v1
https://doi.org/10.1158/2326-6066.c.6550372.v1
Autor:
David B. Weiner, Daniel W. Kulp, Laurent Humeau, Kate E. Broderick, Katherine Schultheis, Paul D. Fisher, Nicholas J. Tursi, Susanne Walker, Mamadou A. Bah, Megan C. Wise, Edgar Tello-Ruiz, Neethu Chokkalingam, Ziyang Xu
Supplementary figures 1-4 and Supplementary Table 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f559d32f2bd184cd82b751b122cf615
https://doi.org/10.1158/2326-6066.22543708.v1
https://doi.org/10.1158/2326-6066.22543708.v1
Autor:
Ebony N. Gary, Nicholas J. Tursi, Bryce M. Warner, Gina Cuismano, Jennifer Connors, Elizabeth M. Parzych, Bryan D. Griffin, Matthew R. Bell, Ali R. Ali, Drew Frase, Casey E. Hojecki, Gabriela A. Canziani, Irwin Chaiken, Toshitha Kannan, Estella Moffat, Carissa Embury-Hyatt, Sarah K. Wooton, Andrew Kossenkov, Ami Patel, Darwyn Kobasa, Michele A. Kutzler, Elias K. Haddad, David B. Weiner
Publikováno v:
Frontiers in Immunology. 14
Despite numerous clinically available vaccines and therapeutics, aged patients remain at increased risk for COVID-19 morbidity. Furthermore, various patient populations, including the aged can have suboptimal responses to SARS-CoV-2 vaccine antigens.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b54d401978c706108c74617a1ffb9c87
https://doi.org/10.3389/fimmu.2023.1138609
https://doi.org/10.3389/fimmu.2023.1138609