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Akademický článek

Stochastic RNA editing of the Complexin C-terminus within single neurons regulates neurotransmitter release

Autor: Elizabeth A. Brija, Zhuo Guan, Suresh K. Jetti, J. Troy Littleton

Publikováno v: Cell Reports, Vol 42, Iss 9, Pp 113152- (2023)

Summary: Neurotransmitter release requires assembly of the SNARE complex fusion machinery, with multiple SNARE-binding proteins regulating when and where synaptic vesicle fusion occurs. The presynaptic protein Complexin (Cpx) controls spontaneous and

Externí odkaz: https://doaj.org/article/65f65c0673bb4aa78e4790b769dd0ec2

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Akademický článek

Mechanisms controlling the trafficking, localization, and abundance of presynaptic Ca2+ channels

Autor: Karen L. Cunningham, J. Troy Littleton

Publikováno v: Frontiers in Molecular Neuroscience, Vol 15 (2023)

Voltage-gated Ca2+ channels (VGCCs) mediate Ca2+ influx to trigger neurotransmitter release at specialized presynaptic sites termed active zones (AZs). The abundance of VGCCs at AZs regulates neurotransmitter release probability (Pr), a key presynapt

Externí odkaz: https://doaj.org/article/2e876efb29624c4d933a2e03312571f9

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Akademický článek

Synaptotagmin 7 switches short-term synaptic plasticity from depression to facilitation by suppressing synaptic transmission

Autor: Takaaki Fujii, Akira Sakurai, J. Troy Littleton, Motojiro Yoshihara

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

Abstract Short-term synaptic plasticity is a fast and robust modification in neuronal presynaptic output that can enhance release strength to drive facilitation or diminish it to promote depression. The mechanisms that determine whether neurons displ

Externí odkaz: https://doaj.org/article/0169aea43b4549faa17ab3ee1c7c007e

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Akademický článek

SNARE Regulatory Proteins in Synaptic Vesicle Fusion and Recycling

Autor: Chad W. Sauvola, J. Troy Littleton

Publikováno v: Frontiers in Molecular Neuroscience, Vol 14 (2021)

Membrane fusion is a universal feature of eukaryotic protein trafficking and is mediated by the soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) family. SNARE proteins embedded in opposing membranes spontaneously assemble

Externí odkaz: https://doaj.org/article/d0c6a9c78a7c469fb0a3dfa5e44373f4

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Akademický článek

Synaptic Properties and Plasticity Mechanisms of Invertebrate Tonic and Phasic Neurons

Autor: Nicole A. Aponte-Santiago, J. Troy Littleton

Publikováno v: Frontiers in Physiology, Vol 11 (2020)

Defining neuronal cell types and their associated biophysical and synaptic diversity has become an important goal in neuroscience as a mechanism to create comprehensive brain cell atlases in the post-genomic age. Beyond broad classification such as n

Externí odkaz: https://doaj.org/article/5b3043ce62ef48e7bf5b6210f72fe120

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Akademický článek

Physical contributors to glenohumeral internal rotation deficit in high school baseball players

Autor: Elizabeth E. Hibberd, Casey E. Shutt, Sakiko Oyama, J. Troy Blackburn, Joseph B. Myers

Publikováno v: Journal of Sport and Health Science, Vol 4, Iss 3, Pp 299-306 (2015)

Background: Glenohumeral internal rotation deficit (GIRD) is a risk factor for shoulder and elbow injury in baseball players. Although this evidence forms a basis for recommending stretching, clinical measures of internal rotation range of motion (RO

Externí odkaz: https://doaj.org/article/530e41ff54854b7c8a52903db6637274

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